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Cancer Causes & Control
Published in: Cancer Causes & Control 9/2007

01-11-2007 | Original Paper

Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphoma

Authors: Mark P. Purdue, Patricia Hartge, Scott Davis, James R. Cerhan, Joanne S. Colt, Wendy Cozen, Richard K. Severson, Yan Li, Stephen J. Chanock, Nathaniel Rothman, Sophia S. Wang

Published in: Cancer Causes & Control | Issue 9/2007

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Abstract

Objective

Recent findings suggest that ultraviolet (UV) radiation exposure may reduce risk of developing non-Hodgkin lymphoma (NHL), but the biologic basis for this relationship remains unclear. We analyzed data from our US population-based case–control study of NHL to investigate whether our previously reported inverse association with sun exposure was dependent upon variants in the vitamin D receptor gene (IVS10 + 283G > A (BsmI), Ex11 + 32T > C (TaqI)), and genes linked to UV-induced immune modulation (IL4, IL10, IL12A, IL12B, TNF).

Methods

UV exposure data was collected from an in-person interview with 551 cases and 462 controls. We calculated odds ratios (OR) and 95% confidence intervals (CI) for sun exposure measures for joint variant-exposure effects.

Results

The association with NHL risk for time in the midday sun within the last decade was dependent upon Ex11 + 32 T > C genotype. Compared to TT carriers who reported < 7 h/week of sun exposure, CC subjects with < 7 h/week of sun exposure had an increased risk of NHL (OR = 1.9, 95% CI 0.8–4.4, Pinteraction = 0.16), while the relative risks for other CC carriers approached unity with increasing level of sun exposure. This pattern of effects was especially apparent for follicular lymphoma (for CC genotype and < 7 h/week of exposure: OR 6.3, 95% CI 1.9–22, Pinteraction = 0.004), and was consistently observed across measures of reported sun exposure for different periods of life. As IVS10 + 283G > A is correlated with Ex11 + 32T > C in our population (r 2 = 0.95), results were equivalent for those with the IVS10 + 283 AA genotype. No evidence of interaction with cytokine gene variants was observed.

Conclusions

Our results suggest that the inverse association between UV exposure and NHL risk may be mediated by the vitamin D pathway. Further investigation of this finding in other studies is warranted.
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Metadata
Title
Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphoma
Authors
Mark P. Purdue
Patricia Hartge
Scott Davis
James R. Cerhan
Joanne S. Colt
Wendy Cozen
Richard K. Severson
Yan Li
Stephen J. Chanock
Nathaniel Rothman
Sophia S. Wang
Publication date
01-11-2007
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 9/2007
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-007-9039-z

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