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01-06-2020 | Suicide | Neurology • Original Article

Comorbid psychiatric disorders among patients with narcolepsy

Authors: Haithm Alasim, Salman AlQazlan, Saleh Albanyan, Abdulaziz Alsalhi, Alwalid Buraik, Awad H. Olaish, Aljohara S. Almeneessier, Fahad D. Alosaimi, Ahmad AlHadi, Ahmed S. BaHammam

Published in: Sleep and Breathing | Issue 2/2020

Abstract

Purpose

This case-control study assessed the prevalence of psychiatric disorders in Arab (Saudi) patients with narcolepsy using a structured clinical interview.

Methods

The study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made according to the International Classification of Sleep Disorders-Third Edition. Psychiatric disorders were diagnosed via using a validated Arabic version of the Mini International Neuropsychiatric Interview DSM-IV (MINI version 6). A multivariate logistic regression model was used to assess the potential influence of narcolepsy on the comorbidity of psychiatric disorders.

Results

The mean age of the patients was 29.4 ± 10.2 years, and males accounted for 81% of the study sample. Forty-four patients (60%) were diagnosed with narcolepsy type-1 (NT1) and 30 (40%) with narcolepsy type-2 (NT2). Psychiatric disorders were diagnosed in 45% of patients with narcolepsy compared with 15% of the controls (p < 0.001). The multivariate logistic regression models demonstrated that compared with the controls, patients with narcolepsy were more likely to have major depressive disorders (OR, 4.3 [CI, 2.2–8.2]), and generalized anxiety disorders (OR, 9.5 [CI, 1.8–50.2]). No difference was detected between the prevalence of various psychiatric disorders in patients with NT1 and NT2.

Conclusion

Comorbid psychiatric disorders are common among Arab (Saudi) patients with narcolepsy compared with the general population. Therefore, clinicians should be aware of the comorbidity of narcolepsy and psychiatric disorders, particularly depression.

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Title: Comorbid psychiatric disorders among patients with narcolepsy
Authors: Haithm Alasim
Salman AlQazlan
Saleh Albanyan
Abdulaziz Alsalhi
Alwalid Buraik
Awad H. Olaish
Aljohara S. Almeneessier
Fahad D. Alosaimi
Ahmad AlHadi
Ahmed S. BaHammam
Publication date: 01-06-2020
Publisher: Springer International Publishing
Keywords: Suicide
Suicide
Multiple Sleep Latency Test
Mood Disorders
Generalised Anxiety Disorder
Hypersomnia
Affective Disorder
Social Anxiety Disorder
Narcolepsy
Published in: Sleep and Breathing / Issue 2/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-019-01890-8

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