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Indian Journal of Otolaryngology and Head & Neck Surgery

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01-11-2019 | Sudden Hearing Loss | Original Article

Assessment of Oxidative Stress in Patients with Sudden Hearing Loss: A Non-randomized Prospective Clinical Study

Authors: Kadir Ozdamar, Alper Sen, Ataman Gonel

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Special Issue 2/2019

Abstract

The etiology of sudden hearing loss (SHL) has not been fully elucidated. Previous studies claimed that different etiological factors may play a role in the pathogenesis of SHL. The aim of the present study is to investigate the presence of oxidative stress (OS) in SHL cases using thiol-disulfide balance. In addition, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and lipid hydroperoxide levels (LOOH) were investigated. A total of 30 cases (15 female, 15 male, mean age 48.9 ± 8.1 years, age range: 36–68 years) were included in the study. Thiol and disulfide amounts, thiol/disulfide ratios, TOS, TAS, OSI and LOOH scores of the case group and control group were compared. Native thiol (SH) and total thiol (SH + SH) values were significantly lower in the SHL group than in the control group (p = 0.028 and p = 0.044, respectively). The LOOH value, TOS value and OSI value were significantly higher in the SHL group than in the control group (all p values < 0.05). The TAS value was significantly lower in the SHL group than in the control group (p = 0.0001). The present study has presented that the thiol-disulfide balance was impaired in SHL cases. OS may play a role in the development of SHL.

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Title: Assessment of Oxidative Stress in Patients with Sudden Hearing Loss: A Non-randomized Prospective Clinical Study
Authors: Kadir Ozdamar
Alper Sen
Ataman Gonel
Publication date: 01-11-2019
Publisher: Springer India
Keyword: Sudden Hearing Loss
Published in: Indian Journal of Otolaryngology and Head & Neck Surgery / Issue Special Issue 2/2019
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-019-01623-z

At a glance: The STEP trials

Springer Medicine

Assessment of Oxidative Stress in Patients with Sudden Hearing Loss: A Non-randomized Prospective Clinical Study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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