Published in:
01-10-2009 | Case Report
Successful treatment of primary AL amyloidosis by VAD therapy, high-dose melphalan, and autologous peripheral stem cell transplantation
Authors:
Osamu Yamazaki, Yoshifumi Ubara, Tatsuya Suwabe, Shohei Nakanishi, Junichi Hoshino, Naoki Sawa, Noriko Hayami, Masayuki Yamanouchi, Fumi Takemoto, Takaichi Kenmei, Kazuhiro Masuoka, Kenichi Oohashi
Published in:
Clinical and Experimental Nephrology
|
Issue 5/2009
Login to get access
Abstract
We report a 58-year-old Japanese man with primary systemic AL amyloidosis who achieved disappearance of proteinuria including Bence-Jones protein (λ-type) after two courses of VAD therapy (vincristine, doxorubicin, and dexamethasone) and subsequent high-dose melphalan, followed by autologous peripheral blood stem cell transplantation. Because this patient did not have any apparent amyloidosis-related heart or liver damage and met all of the eligibility criteria for this therapy, this treatment was performed. Both proteinuria and M-protein disappeared completely, and he is doing well clinically at 19 months after treatment. However, amyloid deposits were still found in the kidneys, including the glomeruli and tubulointerstitium, when renal biopsy was done at 8 months after treatment. In the future, we may reach a time when clinical remission corresponds to histological remission.