Published in:
01-07-2007 | Case Report
Successful treatment of hepatitis B-associated leukocytoclastic vasculitis with lamivudine treatment in a child patient
Authors:
Ozge Surmali Onay, Esra Baskin, Figen Ozçay, Engin Melek, Oguz Canan, Banu Bilezikçi
Published in:
Rheumatology International
|
Issue 9/2007
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Abstract
Chronic hepatitis B infection (HBI) has many extrahepatic manifestations such as vasculitis, glomerulonephritis, arthritis, dermatitis, pulmonary disease, and skin manifestations. The mechanism of these manifestations is thought to be immune mediated. Immune-suppressive treatment may enhance viral replication and worsen hepatic disease. Lamivudine is a nucleoside analogue used in chronic HBI treatment that works by suppressing replication of the hepatitis B virus (HBV). Recently, several reports have suggested that lamivudine treats vasculitis associated with HBV infection in adults. However, there are no data in the literature for children. Herein, we report a child with leukocytoclastic vasculitis due to chronic HBI who was successfully treated with lamivudine.