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Published in: Modern Rheumatology 6/2010

01-12-2010 | Case Report

Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine

Authors: Satoru Akazawa, Kunihiro Ichinose, Tomoki Origuchi, Shin-ya Kawashiri, Naoki Iwamoto, Keita Fujikawa, Toshiyuki Aramaki, Makoto Kamachi, Kazuhiko Arima, Mami Tamai, Hideki Nakamura, Hiroaki Ida, Atsushi Kawakami, Katsumi Eguchi

Published in: Modern Rheumatology | Issue 6/2010

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Abstract

A 36-year-old female patient who was diagnosed with chronic myocarditis as an initial manifestation of systemic lupus erythematosus (SLE) was admitted to our hospital. At her third occurrence of heart failure, we performed an endomyocardial biopsy and proved chronic myocarditis with SLE. Subsequently, she was treated with prednisolone and the immunosuppressive agent mizoribine (MZR), and her cardiac function improved. We describe for the first time treatment with MZR for chronic cardiac involvement of SLE.
Literature
1.
2.
go back to reference Chan YK, Li EK, Tam LS, Chow LT, Ng HK. Intravenous cyclophosphamide improves cardiac dysfunction in lupus myocarditis. Scand J Rheumatol. 2003;32:306–8.PubMedCrossRef Chan YK, Li EK, Tam LS, Chow LT, Ng HK. Intravenous cyclophosphamide improves cardiac dysfunction in lupus myocarditis. Scand J Rheumatol. 2003;32:306–8.PubMedCrossRef
3.
go back to reference Gottenberg JE, Roux S, Assayag P, Clerc D, Mariette X. Specific cardiomyopathy in lupus patients: report of three cases. Joint Bone Spine. 2004;71:66–9.PubMedCrossRef Gottenberg JE, Roux S, Assayag P, Clerc D, Mariette X. Specific cardiomyopathy in lupus patients: report of three cases. Joint Bone Spine. 2004;71:66–9.PubMedCrossRef
4.
go back to reference Brigden W, Bywaters EG, Lessof MH, Ross IP. The heart in systemic lupus erythematosus. Br Heart J. 1960;22:1–16.PubMedCrossRef Brigden W, Bywaters EG, Lessof MH, Ross IP. The heart in systemic lupus erythematosus. Br Heart J. 1960;22:1–16.PubMedCrossRef
5.
go back to reference Bidani AK, Roberts JL, Schwartz MM, Lewis EJ. Immunopathology of cardiac lesions in fatal systemic lupus erythematosus. Am J Med. 1980;69:849–58.PubMedCrossRef Bidani AK, Roberts JL, Schwartz MM, Lewis EJ. Immunopathology of cardiac lesions in fatal systemic lupus erythematosus. Am J Med. 1980;69:849–58.PubMedCrossRef
6.
go back to reference Bulkley BH, Roberts WC. The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy. A study of 36 necropsy patients. Am J Med. 1975;58:243–64.PubMedCrossRef Bulkley BH, Roberts WC. The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy. A study of 36 necropsy patients. Am J Med. 1975;58:243–64.PubMedCrossRef
7.
go back to reference Logar D, Kveder T, Rozman B, Dobovisek J. Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. Ann Rheum Dis. 1990;49:627–9.PubMedCrossRef Logar D, Kveder T, Rozman B, Dobovisek J. Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. Ann Rheum Dis. 1990;49:627–9.PubMedCrossRef
8.
go back to reference Vogel-Claussen J, Rochitte CE, Wu KC, Kamel IR, Foo TK, Lima JA, et al. Delayed enhancement MR imaging: utility in myocardial assessment. Radiographics. 2006;26:795–810.PubMedCrossRef Vogel-Claussen J, Rochitte CE, Wu KC, Kamel IR, Foo TK, Lima JA, et al. Delayed enhancement MR imaging: utility in myocardial assessment. Radiographics. 2006;26:795–810.PubMedCrossRef
9.
go back to reference Mahrholdt H, Goedecke C, Wagner A, Meinhardt G, Athanasiadis A, Vogelsberg H, et al. Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and molecular pathology. Circulation. 2004;109:1250–8.PubMedCrossRef Mahrholdt H, Goedecke C, Wagner A, Meinhardt G, Athanasiadis A, Vogelsberg H, et al. Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and molecular pathology. Circulation. 2004;109:1250–8.PubMedCrossRef
10.
go back to reference Naarendorp M, Kerr LD, Khan AS, Ornstein MH. Dramatic improvement of left ventricular function after cytotoxic therapy in lupus patients with acute cardiomyopathy: report of 6 cases. J Rheumatol. 1999;26:2257–60.PubMed Naarendorp M, Kerr LD, Khan AS, Ornstein MH. Dramatic improvement of left ventricular function after cytotoxic therapy in lupus patients with acute cardiomyopathy: report of 6 cases. J Rheumatol. 1999;26:2257–60.PubMed
11.
go back to reference Takahashi S, Wakui H, Gustafsson JA, Zilliacus J, Itoh H. Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein. Biochem Biophys Res Commun. 2000;274:87–92.PubMedCrossRef Takahashi S, Wakui H, Gustafsson JA, Zilliacus J, Itoh H. Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein. Biochem Biophys Res Commun. 2000;274:87–92.PubMedCrossRef
12.
go back to reference Chung JW, Joe DY, Park HJ, Kim HA, Park HS, Suh CH. Clinical characteristics of lupus myocarditis in Korea. Rheumatol Int. 2008;28:275–80.PubMedCrossRef Chung JW, Joe DY, Park HJ, Kim HA, Park HS, Suh CH. Clinical characteristics of lupus myocarditis in Korea. Rheumatol Int. 2008;28:275–80.PubMedCrossRef
13.
go back to reference Busteed S, Sparrow P, Molloy C, Molloy MG. Myocarditis as a prognostic indicator in systemic lupus erythematosus. Postgrad Med J. 2004;80:366–7.PubMedCrossRef Busteed S, Sparrow P, Molloy C, Molloy MG. Myocarditis as a prognostic indicator in systemic lupus erythematosus. Postgrad Med J. 2004;80:366–7.PubMedCrossRef
14.
go back to reference Suri V, Varma S, Joshi K, Malhotra P, Kumari S, Jain S. Lupus myocarditis: marked improvement in cardiac function after intravenous immunoglobulin therapy. Rheumatol Int 2009. doi:10.1007/s00296-009-1098-x Suri V, Varma S, Joshi K, Malhotra P, Kumari S, Jain S. Lupus myocarditis: marked improvement in cardiac function after intravenous immunoglobulin therapy. Rheumatol Int 2009. doi:10.​1007/​s00296-009-1098-x
Metadata
Title
Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine
Authors
Satoru Akazawa
Kunihiro Ichinose
Tomoki Origuchi
Shin-ya Kawashiri
Naoki Iwamoto
Keita Fujikawa
Toshiyuki Aramaki
Makoto Kamachi
Kazuhiko Arima
Mami Tamai
Hideki Nakamura
Hiroaki Ida
Atsushi Kawakami
Katsumi Eguchi
Publication date
01-12-2010
Publisher
Springer Japan
Published in
Modern Rheumatology / Issue 6/2010
Print ISSN: 1439-7595
Electronic ISSN: 1439-7609
DOI
https://doi.org/10.1007/s10165-010-0326-2

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