Published in:
01-09-2009 | Original Paper
Substantially reduced expression of PIAS1 is associated with colon cancer development
Published in: Journal of Cancer Research and Clinical Oncology | Issue 9/2009
Login to get accessAbstract
Purpose
Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-γ) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS’s also regulate STAT family members not directly involved in IFN-γ signaling. This project was designed to assess PIAS1 expression in colon cancer.
Methods
To determine whether PIAS1, one of the PIAS family members, or IFN-γ signaling pathway components could be used to stratify colon tumors, we stained tissue microarrays for PIAS1, interferon regulatory factor-1 (IRF-1) and STAT1α.
Results
PIAS1 staining of the colon cancer tissue microarrays indicated a strong correlation of normal colon cells, and adenomas, with high expression of both PIAS1 and IRF-1.
Conclusion
The PIAS1 results in particular may represent a basis for new approaches for efficiently distinguishing adenomas from colon cancer.