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Irish Journal of Medical Science (1971 -)

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29-09-2021 | Subarachnoid Hemorrhage | Original Article

Assessment of BNP and BDNF results in elective endovascular cerebral aneurysm treatment

Authors: Abdullah Sukun, Bulent Cekic

Published in: Irish Journal of Medical Science (1971 -) | Issue 4/2022

Abstract

Background

B-type natriuretic peptide (BNP) levels increase with an increase in intracranial pressure. A decrease in BNP levels has been found to be associated with patient positive prognosis. Brain-derived neurotrophic factor (BDNF) levels decrease in patients with acute stroke.

Aims

To compare the BNP and BDNF values in serum before and after elective endovascular cerebral aneurysm treatment (ECAT).

Methods

A total of 50 patients who underwent elective ECAT were included in the study. Exclusion criteria were determined to be history of heart failure or heart attack (n = 8), renal failure (n = 5), subarachnoid hemorrhage (n = 4), or previous aneurysm clip procedure (n = 3). Intravenous blood samples were obtained from 30 patients who underwent elective ECAT before and after treatment. After centrifugation, the BNP and BDNF values in serum were obtained with the ELISA method and compared.

Results

This study included 19 female and 11 male patients, aged between 24 and 75 years. The average age of the patients was 51.27 ± 13.31 years. The median BDNF values did not change significantly after ECAT (before the endovascular procedure: 3.1 ± 1.3 pg/dl; after the endovascular procedure: 2.8 ± 0.9 pg/dl, p = 0.16). Median BNP levels decreased significantly after ECAT (before the endovascular procedure: 617.50 ± 483.11 pg/ml; after the endovascular procedure: 395.00 ± 352.15 pg/ml, p < 0.001).

Conclusions

After elective endovascular cerebral aneurysm treatment, the BNP values in serum decreased significantly, and the BDNF values in serum did not change significantly.

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Title: Assessment of BNP and BDNF results in elective endovascular cerebral aneurysm treatment
Authors: Abdullah Sukun
Bulent Cekic
Publication date: 29-09-2021
Publisher: Springer International Publishing
Keywords: Subarachnoid Hemorrhage
Stroke
Aneurysm
Aneurysm
Intracranial Hypertension
Subarachnoid Hemorrhage
Published in: Irish Journal of Medical Science (1971 -) / Issue 4/2022
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-021-02791-0

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Abstract

Background

Aims

Methods

Results

Conclusions

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