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Neurological Sciences

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01-07-2020 | Subarachnoid Hemorrhage | Original Article

The accuracy of aneurysm size in predicting rebleeding after subarachnoid hemorrhage: a meta-analysis

Authors: Zhiyuan Yu, Jun Zheng, Rui Guo, Mou Li, Hao Li, Lu Ma, Chao You

Published in: Neurological Sciences | Issue 7/2020

Abstract

Background

Aneurysmal subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease. Rebleeding is an independent predictor of unfavorable outcome after aneurysmal SAH. However, the accuracy of aneurysm size for predicting rebleeding after aneurysmal SAH is still unclear. Hence, we conducted this meta-analysis to evaluate the predictive accuracy of large aneurysm for rebleeding after SAH.

Methods

We performed a literature search in PubMed and Embase. Original studies about aneurysm size and rebleeding after SAH were included. Two reviewers completed data extraction and quality assessment. Pooled sensitivity, specificity, and their 95% confidence intervals (CIs) of large aneurysm for predicting rebleeding were calculated and shown in a forest plot. The overall accuracy of large aneurysm for predicting rebleeding after SAH was shown using a summary receiver operating characteristic (SROC) curve. Publication bias were assessed using Deeks’ funnel plot.

Results

A total of ten studies with 3889 patients met eligibility criteria and were included in this meta-analysis. The pooled sensitivity and specificity of large aneurysm for predicting rebleeding were 0.39 (95% CI 0.25–0.56) and 0.75 (95% CI 0.67–0.82), respectively. The area under SROC curve was 0.67 (95% CI 0.62–0.71). Deeks’ funnel plot did not show obvious publication bias among included studies in this meta-analysis.

Conclusion

The specificity of large aneurysm for predicting rebleeding after SAH is relatively high. However, its overall accuracy for predicting aneurysm rebleeding is not very satisfying. A comprehensive model should be developed to improve the accuracy of rebleeding prediction after SAH.

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Title: The accuracy of aneurysm size in predicting rebleeding after subarachnoid hemorrhage: a meta-analysis
Authors: Zhiyuan Yu
Jun Zheng
Rui Guo
Mou Li
Hao Li
Lu Ma
Chao You
Publication date: 01-07-2020
Publisher: Springer International Publishing
Keywords: Subarachnoid Hemorrhage
Aneurysm
Aneurysm
Subarachnoid Hemorrhage
Published in: Neurological Sciences / Issue 7/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04297-6

At a glance: The STEP trials

Springer Medicine

The accuracy of aneurysm size in predicting rebleeding after subarachnoid hemorrhage: a meta-analysis

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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