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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Research

Structural equation modelling exploration of the key pathophysiological processes involved in cardiac surgery-related acute kidney injury in infants

Authors: Mirela Bojan, Maria Constanza Basto Duarte, Natalia Ermak, Vanessa Lopez-Lopez, Agnès Mogenet, Marc Froissart

Published in: Critical Care | Issue 1/2016

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Abstract

Background

Uncertainties about the pathophysiological processes resulting in cardiac surgery-related acute kidney injury (AKI) in infants concern the relative impact of the most prominent risk factors, the clinical relevance of changes in glomerular filtration rate vs tubular injury, and the usefulness of available diagnostic tools. Structural equation modelling could allow for the assessment of these complex relationships.

Methods

A structural model was specified using data from a prospective observational cohort of 200 patients <1 year of age undergoing cardiopulmonary bypass surgery. It included four latent variables: AKI, modelled as a construct of perioperative creatinine variation, of oliguria and of urine neutrophil gelatinase-associated lipocalin (uNGAL) concentrations; the cardiopulmonary bypass characteristics; the occurrence of a post-operative low cardiac output syndrome and the post-operative outcome.

Results

The model showed a good fit, and all path coefficients were statistically significant. The bypass was the most prominent risk factor, with a path coefficient of 0.820 (95 % CI 0.527–0.979), translating to a 67.2 % explanation for the risk of AKI. A strong relationships was found between AKI and early uNGAL excretion, and between AKI and the post-operative outcome, with path coefficients of 0.611 (95 % CI 0.347–0.777) and 0.741 (95 % CI 0.610–0.988), respectively. The path coefficient between AKI and a >50 % increase in serum creatinine was smaller, with a path coefficient of 0.443 (95 % CI 0.273–0.596), and was intermediate for oliguria, defined as urine output <0.5 ml kg−1 h−1, with a path coefficient of 0.495 (95 % CI 0.250–0.864). A path coefficient of −0.229 (95 % CI −0.319 to 0.060) suggested that the risk of AKI during the first year of life did not increase with younger age at surgery.

Conclusions

These findings suggest that cardiac surgery-related AKI in infants is a translation of tubular injury, predominately driven by the cardiopulmonary bypass, and linked to early uNGAL excretion and to post-operative outcome.

Trial registration

ClinicalTrials.gov identifier NCT01219998. Registered 11 October 2010.
Appendix
Available only for authorised users
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Metadata
Title
Structural equation modelling exploration of the key pathophysiological processes involved in cardiac surgery-related acute kidney injury in infants
Authors
Mirela Bojan
Maria Constanza Basto Duarte
Natalia Ermak
Vanessa Lopez-Lopez
Agnès Mogenet
Marc Froissart
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1350-1

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