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01-06-2013 | Translational Neurosciences - Short communication

Structural comparison of the active site channels in rodent and primate vascular adhesion protein-1

Authors: Eva Bligt-Lindén, Ramaiah Arunachalam, Vimal Parkash, Tiina Annamaria Salminen

Published in: Journal of Neural Transmission | Issue 6/2013

Abstract

In this study, we have made homology models of mouse, rat, and monkey vascular adhesion protein-1 (VAP-1) to reveal basis for the species-specific ligand recognition of VAP-1. Based on the structural comparisons, rodent VAP-1s have a narrower active site channel than primate VAP-1s. The variable residues in mouse and rat VAP-1, Phe447 from arm I and the polar residues from the first α-helix of the D3 domain together with C-terminal residues are likely to affect ligand recognition and binding.

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Title: Structural comparison of the active site channels in rodent and primate vascular adhesion protein-1
Authors: Eva Bligt-Lindén
Ramaiah Arunachalam
Vimal Parkash
Tiina Annamaria Salminen
Publication date: 01-06-2013
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 6/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-0974-4

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Structural comparison of the active site channels in rodent and primate vascular adhesion protein-1

Abstract

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Abstract

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