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01-06-2013 | Translational Neurosciences - Short communication

Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation

Authors: Tamás Tábi, Éva Szökő, Anita Mérey, Veronika Tóth, Péter Mátyus, Klára Gyires

Published in: Journal of Neural Transmission | Issue 6/2013

Abstract

SSAO/VAP-1 participates in the accumulation of leukocytes at the site of inflammation. A new SSAO inhibitor, SzV-1287 was demonstrated to inhibit both acute and chronic inflammation in rats more effectively than the known enzyme inhibitor, LJP-1207. Surprisingly, the SSAO activity was not increased, but decreased both in acute and chronic inflammation. Though experiments are in progress to clarify these findings, the enzyme might play a role in the very early phase of inflammation and be inactivated during leukocyte extravasation.

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Title: Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation
Authors: Tamás Tábi
Éva Szökő
Anita Mérey
Veronika Tóth
Péter Mátyus
Klára Gyires
Publication date: 01-06-2013
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 6/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-012-0961-1

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Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation

Abstract

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Abstract

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