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Acta Neurologica Belgica

Published in:

04-09-2023 | Stroke | Original article

The utility of heart-type free fatty-acid binding-protein (HFABP) levels for differentiating acute ischemic stroke from stroke mimics

Authors: Emir Unal, Haldun Akoglu, Erkman Sanri, Sinan Karacabey, Melis Efeoglu Sacak, Ozge Onur, Arzu Denizbasi

Published in: Acta Neurologica Belgica | Issue 1/2024

Abstract

Background

Heart-type fatty acid-binding protein (HFABP) is found in the myocardium, brain, and some organs and is rapidly released from damaged cells into the circulation in case of ischemia.

Aims

We aimed to determine the diagnostic utility of HFABP levels in patients suggesting acute ischemic stroke (AIS).

Methods

This study was a prospective, single-center, observational diagnostic accuracy study with a nested cohort design. The estimated sample size was 126 patients, with a 1:1 case and control ratio. We included all consecutive patients with a lateralizing symptom (motor or sensory) or finding suggesting AIS (139 patients) who presented to ED within 24 h of their symptom onset and collected plasma at admission to the ED. After further evaluations, 111 patients (79.8%) were diagnosed with AIS and 28 with other neurological diseases (stroke-mimics).

Findings

In our study, the median HFABP levels of the cases and controls were 2.6 μg/ml and 2.2 μg/ml, respectively, without any statistically significant difference (p = 0.120). The diagnostic accuracy of HFABP for AIS was also insignificant at 0.60 (95% CI 0.51–0.68; p = 0.119).

Discussion

Plasma HFABP level is not a marker that can differentiate AIS from other neurological pathologies in patients presenting to the ED, with findings suggesting AIS.

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Title: The utility of heart-type free fatty-acid binding-protein (HFABP) levels for differentiating acute ischemic stroke from stroke mimics
Authors: Emir Unal
Haldun Akoglu
Erkman Sanri
Sinan Karacabey
Melis Efeoglu Sacak
Ozge Onur
Arzu Denizbasi
Publication date: 04-09-2023
Publisher: Springer International Publishing
Keyword: Stroke
Published in: Acta Neurologica Belgica / Issue 1/2024
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-023-02372-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The utility of heart-type free fatty-acid binding-protein (HFABP) levels for differentiating acute ischemic stroke from stroke mimics

Abstract

Background

Aims

Methods

Findings

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Aims

Methods

Findings

Discussion

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