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01-08-2019 | Stroke | Review Article

Oxidative stress and stroke: a review of upstream and downstream antioxidant therapeutic options

Author: Detelina Komsiiska

Published in: Comparative Clinical Pathology | Issue 4/2019

Abstract

The stroke is a cerebrovascular disorder and is the cause of a second mortality and long-lasting harm worldwide. It is classified into two types: hemorrhagic and ischemic stroke. Globally, 13% of cases of stroke are hemorrhagic, while the remaining 87% are ischemic. In this paper, we discuss the consideration of factors which possibly affect the effectiveness of antioxidant protection under oxygen deprivation, as well as oxidative stress. Such aspects as compartmentalization of reactive oxygen species (ROS)/reactive nitrogen species (RNS) formation and antioxidant localization, synthesis and transport of antioxidants, and ability to induce the antioxidant defense and cooperation (and/or compensation) between different antioxidant systems are the determinants of the competence of the antioxidant system. Overall, we describe the antioxidants, which interact with ROS and RNS, and terminated the chain reaction before vital molecules have been injured.

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Title: Oxidative stress and stroke: a review of upstream and downstream antioxidant therapeutic options
Author: Detelina Komsiiska
Publication date: 01-08-2019
Publisher: Springer London
Keyword: Stroke
Published in: Comparative Clinical Pathology / Issue 4/2019
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-019-02940-z

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Oxidative stress and stroke: a review of upstream and downstream antioxidant therapeutic options

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