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BMC Neurology
Published in: BMC Neurology 1/2024

Open Access 01-12-2024 | Stroke | Research

Differential expression of Semaphorin-7A /CD163-positive macrophages in large artery and cardiogenic stroke

Authors: Yi Jiang, Zhichao Sun, Zhonglin Ge, Zhonghai Tao, Mengqian Liu, Wen Zhong, Nan Dong, Lei Xu, Hui Wang, Yiwen Xu, Xiaozhu Shen

Published in: BMC Neurology | Issue 1/2024

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Abstract

Background

Identification of the causes of stroke of undetermined etiology, specifically cardioembolism (CE) and non-CE causes, can inform treatment planning and prognosis prediction. The objective of this study was to analyze the disparities in thrombus composition, particularly Semaphorin-7A (Sema7A) and CD163, between patients diagnosed with large-artery atherosclerosis (LAA) and those with CE, and to investigate their potential association with prognosis.

Methods

Thrombi were collected from patients who underwent mechanical thrombectomy at two hospitals. The patients were categorized into two groups: LAA and CE. We compared the levels of Sema7A and CD163 between these groups and analyzed their relationships with stroke severity, hemorrhagic transformation and prognosis.

Results

The study involved a total of 67 patients. Sema7A expression was found to be significantly higher in the CE group compared to LAA (p < 0.001). Conversely, no statistically significant differences were observed for CD163 between the groups. The presence of Sema7A/CD163 did not show any associations with stroke severity or hemorrhagic transformation (all p > 0.05). However, both Sema7A (OR, 2.017; 95% CI, 1.301–3.518; p = 0.005) and CD163 (OR, 2.283; 95% CI, 1.252–5.724; p = 0.03) were associated with the poor prognosis for stroke, after adjusting for stroke severity.

Conclusion

This study highlights that CE thrombi exhibited higher levels of Sema7A expression compared to LAA thrombi. Moreover, we found a positive correlation between Sema7A/CD163 levels and the poor prognosis of patients with acute ischemic stroke.
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Metadata
Title
Differential expression of Semaphorin-7A /CD163-positive macrophages in large artery and cardiogenic stroke
Authors
Yi Jiang
Zhichao Sun
Zhonglin Ge
Zhonghai Tao
Mengqian Liu
Wen Zhong
Nan Dong
Lei Xu
Hui Wang
Yiwen Xu
Xiaozhu Shen
Publication date
01-12-2024
Publisher
BioMed Central
Keyword
Stroke
Published in
BMC Neurology / Issue 1/2024
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-024-03559-6

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