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Published in: Journal of Diabetes & Metabolic Disorders 2/2019

01-12-2019 | Stroke | Review article

Relationship between hemoglobin A1c and serum troponin in patients with diabetes and cardiovascular events

Authors: Stjepan Šimić, Tomo Svaguša, Ingrid Prkačin, Tomislav Bulum

Published in: Journal of Diabetes & Metabolic Disorders | Issue 2/2019

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Abstract

Objectives

Diabetes mellitus is a group of metabolic disorders associated with high risk for cardiovascular disease. Although troponins are primarily clinically used for the diagnosis of acute coronary syndrome, they are also used in risk assessment in patients with acute coronary syndrome as well as in a number of other conditions. The aim of this review was to investigate the relationship between hemoglobin A1c and serum troponin in patients with diabetes and cardiovascular events.

Methods

Hemoglobin A1c has been chosen as the best clinical indicator of glucose control and risk of micro and macrovascular complications. We investigated cardiac troponins as a group of markers of muscle injury which includes troponin T, troponin I and troponin C. Troponin T and I are specific for myocardial injury, compared to C which is specific for skeletal muscle.

Results

In this review, we showed that there was a causal relation between hemoglobin A1c levels and serum troponin concentrations. Hemoglobin A1c has shown to be a positive predictive factor of incidence, mortality and morbidity of conditions such as acute coronary syndrome, arrhythmias, stroke, pulmonary embolism and other conditions that causes troponin elevation by its release in circulation.

Conclusions

Chronic hyperglycemia decreases glomerular filtration and consequently decreases troponin elimination and also by affecting the heart microcirculation it leads to microvascular damage and consequently to ischemia which contribute to troponin concentration elevation. Furthermore, correlation between hemoglobin A1c and troponin concentration manifests in their prognostic value for mortality.
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Metadata
Title
Relationship between hemoglobin A1c and serum troponin in patients with diabetes and cardiovascular events
Authors
Stjepan Šimić
Tomo Svaguša
Ingrid Prkačin
Tomislav Bulum
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Journal of Diabetes & Metabolic Disorders / Issue 2/2019
Electronic ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-019-00460-9

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