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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

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Open Access 01-12-2024 | Stroke | Research

The role of blood protein biomarkers in acute ischemic stroke prognosis

Authors: Asmaa Sabbah, Mohamed Elsayed, Hanan Helmy, Riham Hamdy Mostafa, Ghada Hatem

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2024

Abstract

Background

Stroke is one of the most frequent causes of mortality and disability, blood protein biomarkers are used to determine patients at high risk for a severe illness and to estimate the outcome. This study aimed to detect the relation between serum levels of C-reactive protein, matrix metalloproteinase 9, S100 calcium-binding protein B, brain natriuretic peptide, D-dimer and stroke severity and outcome in acute ischemic stroke patients.

Results

One hundred eighty-six patients with acute ischemic stroke participated and were subjected to complete general, neurological examination, assessment of stroke severity clinically and radiologically using National Institute of Health Stroke Scale (NIHSS), and Alberta Stroke Program Early CT (ASPECT) score and assessment of functional outcome using (modified Rankin Scale). C-reactive protein, matrix metalloproteinase 9, S100 calcium-binding protein B, brain natriuretic peptide and D-dimer were assessed. Higher C-reactive protein was found in patients with ASPECT score ≤ 7 and in patients with cerebral edema, seizures and was positively correlated with stroke severity according to NIHSS and modified Rankin Scale. C-reactive protein serum level at onset was negatively correlated with NIHSS at onset and is a significant predictor for mortality. D-dimer was negatively correlated with NIHSS. S100 calcium-binding protein B was significantly elevated in patients who developed hemorrhagic transformation.

Conclusions

Serum C-reactive protein level can be used as a predictor for mortality and higher S100 calcium-binding protein B was detected in patients with hemorrhagic transformation.

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Title: The role of blood protein biomarkers in acute ischemic stroke prognosis
Authors: Asmaa Sabbah
Mohamed Elsayed
Hanan Helmy
Riham Hamdy Mostafa
Ghada Hatem
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Stroke
Biomarkers
Cerebral Edema
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery / Issue 1/2024
Electronic ISSN: 1687-8329
DOI: https://doi.org/10.1186/s41983-024-00829-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The role of blood protein biomarkers in acute ischemic stroke prognosis

Abstract

Background

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Results

Conclusions

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