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Heart and Vessels
Published in: Heart and Vessels 1/2021

Open Access 01-01-2021 | Streptococci | Original Article

Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs

Authors: Tokiko Tabata, Tomoya Yamashita, Koji Hosomi, Jonguk Park, Tomohiro Hayashi, Naofumi Yoshida, Yoshihiro Saito, Koji Fukuzawa, Kana Konishi, Haruka Murakami, Hitoshi Kawashima, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa, Ken-ichi Hirata

Published in: Heart and Vessels | Issue 1/2021

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Abstract

Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a causal relationship between AF and gut microbiota dysbiosis; however, the relationship remains poorly understood. We prospectively enrolled 34 hospitalized patients with AF and 66 age-, sex-, and comorbidity-matched control subjects without a history of AF. Gut microbial compositions were evaluated by amplicon sequencing targeting the 16S ribosomal RNA gene. We assessed differences in dietary habits by using a brief-type self-administered diet history questionnaire (BDHQ). Gut microbial richness was lower in AF patients, although the diversity of gut microbiota did not differ between the two groups. At the genus level, Enterobacter was depleted, while Parabacteroides, Lachnoclostridium, Streptococcus, and Alistipes were enriched in AF patients compared to control subjects. The BDHQ revealed that the intake of n-3 polyunsaturated fatty acids and eicosadienoic acid was higher in AF patients. Our results suggested that AF patients had altered gut microbial composition in connection with dietary habits.
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Metadata
Title
Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs
Authors
Tokiko Tabata
Tomoya Yamashita
Koji Hosomi
Jonguk Park
Tomohiro Hayashi
Naofumi Yoshida
Yoshihiro Saito
Koji Fukuzawa
Kana Konishi
Haruka Murakami
Hitoshi Kawashima
Kenji Mizuguchi
Motohiko Miyachi
Jun Kunisawa
Ken-ichi Hirata
Publication date
01-01-2021
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 1/2021
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-020-01669-y

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