Skip to main content
Top
Published in: Sports Medicine 4/2000

01-10-2000 | Review Article

Strength Training in the Elderly

Effects on Risk Factors for Age-Related Diseases

Authors: Dr Ben F. Hurley, Stephen M. Roth

Published in: Sports Medicine | Issue 4/2000

Login to get access

Abstract

Strength training (ST) is considered a promising intervention for reversing the loss of muscle function and the deterioration of muscle structure that is associated with advanced age. This reversal is thought to result in improvements in functional abilities and health status in the elderly by increasing muscle mass, strength and power and by increasing bone mineral density (BMD). In the past couple of decades, many studies have examined the effects of ST on risk factors for age-related diseases or disabilities. Collectively, these studies indicate that ST in the elderly: (i) is an effective intervention against sarcopenia because it produces substantial increases in the strength, mass, power and quality of skeletal muscle; (ii) can increase endurance performance; (iii) normalises blood pressure in those with high normal values; (iv) reduces insulin resistance; (v) decreases both total and intra-abdominal fat; (vi) increases resting metabolic rate in older men; (vii) prevents the loss of BMD with age; (viii) reduces risk factors for falls; and (ix) may reduce pain and improve function in those with osteoarthritis in the knee region. However, contrary to popular belief, ST does not increase maximal oxygen uptake beyond normal variations, improve lipoprotein or lipid profiles, or improve flexibility in the elderly.
Literature
1.
go back to reference Larsson L, Grimby G, Karlsson J. Muscle strength and speed of movement in relation to age and muscle morphology. J Appl Physiol 1979; 46: 451–6PubMed Larsson L, Grimby G, Karlsson J. Muscle strength and speed of movement in relation to age and muscle morphology. J Appl Physiol 1979; 46: 451–6PubMed
2.
go back to reference Lindle R, Metter E, Lynch N, et al. Age and gender comparisons of muscle strength in 654 women andmen aged 20–93. J Appl Physiol 1997; 83: 1581–7PubMed Lindle R, Metter E, Lynch N, et al. Age and gender comparisons of muscle strength in 654 women andmen aged 20–93. J Appl Physiol 1997; 83: 1581–7PubMed
3.
go back to reference Lynch NA, Metter EJ, Lindle RS, et al. Muscle quality I: age-associated differences in arm vs leg muscle groups. J Appl Physiol 1999; 86 (1): 188–94 Lynch NA, Metter EJ, Lindle RS, et al. Muscle quality I: age-associated differences in arm vs leg muscle groups. J Appl Physiol 1999; 86 (1): 188–94
4.
go back to reference Butler R. Did you say ’sarcopenia’? Geriatrics 1993; 48: 11–2 Butler R. Did you say ’sarcopenia’? Geriatrics 1993; 48: 11–2
5.
go back to reference Young A, Skelton D. Applied physiology of strength and power in old age. Int J Sports Med 1994; 15: 149–51PubMedCrossRef Young A, Skelton D. Applied physiology of strength and power in old age. Int J Sports Med 1994; 15: 149–51PubMedCrossRef
6.
go back to reference Buchner D, Wagner E. Preventing frail health. Clin Geriatr Med 1992; 8: 1–17PubMed Buchner D, Wagner E. Preventing frail health. Clin Geriatr Med 1992; 8: 1–17PubMed
7.
go back to reference Rantanen T, Guralnik JM, Ferrucci L, et al. Coimpairments: strength and balance as predictors of severe walking disability. J Gerontol A Biol Sci Med Sci 1999; 54A: M172–6CrossRef Rantanen T, Guralnik JM, Ferrucci L, et al. Coimpairments: strength and balance as predictors of severe walking disability. J Gerontol A Biol Sci Med Sci 1999; 54A: M172–6CrossRef
8.
go back to reference Rantanen T, Guralnik JM, Foley D, et al. Midlife hand grip strength as a predictor of old age disability. JAMA 1999; 281: 558–60PubMedCrossRef Rantanen T, Guralnik JM, Foley D, et al. Midlife hand grip strength as a predictor of old age disability. JAMA 1999; 281: 558–60PubMedCrossRef
9.
go back to reference Rantanen T, Guralnik JM, Sakari-Rantala R, et al. Disability, physical activity, and muscle strength in older women: The women’s health and aging study. Arch Phys Med Rehab 1999; 80: 130–5CrossRef Rantanen T, Guralnik JM, Sakari-Rantala R, et al. Disability, physical activity, and muscle strength in older women: The women’s health and aging study. Arch Phys Med Rehab 1999; 80: 130–5CrossRef
10.
go back to reference Campbell A, Borrie M, Spears G. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol 1989; 44: M112–7PubMed Campbell A, Borrie M, Spears G. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol 1989; 44: M112–7PubMed
11.
go back to reference Aniansson A, Zetterberg C, Hadberg M, et al. Impaired muscle function with aging: a background factor in the incidence of fractures of the proximal end of the femur. Clin Orthop Relat Res 1984; 191: 193–200PubMed Aniansson A, Zetterberg C, Hadberg M, et al. Impaired muscle function with aging: a background factor in the incidence of fractures of the proximal end of the femur. Clin Orthop Relat Res 1984; 191: 193–200PubMed
12.
go back to reference Sinaki M, McPhee M, Hodgson S, et al. Relationship between bone mineral density of spine and strength of back extensors in healthy postmenopausal women. Mayo Clin Proc 1986; 61: 116–22PubMedCrossRef Sinaki M, McPhee M, Hodgson S, et al. Relationship between bone mineral density of spine and strength of back extensors in healthy postmenopausal women. Mayo Clin Proc 1986; 61: 116–22PubMedCrossRef
13.
go back to reference Bloesch D, Schultz Y, Breitenstein E, et al. Thermogenic response to an oral glucose load in man: comparison between young and elderly subjects. J Am Coll Nutr 1988; 7: 471–83PubMed Bloesch D, Schultz Y, Breitenstein E, et al. Thermogenic response to an oral glucose load in man: comparison between young and elderly subjects. J Am Coll Nutr 1988; 7: 471–83PubMed
14.
go back to reference Bassey E, Fiatarone M, O’Neil E, et al. Leg extensor power and functional performance in very old men and women. Clin Sci 1992; 82: 321–7PubMed Bassey E, Fiatarone M, O’Neil E, et al. Leg extensor power and functional performance in very old men and women. Clin Sci 1992; 82: 321–7PubMed
15.
go back to reference Hyatt R, Whitelaw M, Bhat A, et al. Association of muscle strength with functional status of elderly people. Age Ageing 1990; 19: 330–6PubMedCrossRef Hyatt R, Whitelaw M, Bhat A, et al. Association of muscle strength with functional status of elderly people. Age Ageing 1990; 19: 330–6PubMedCrossRef
16.
go back to reference Buchner D, de Lateur BJ. The importance of skeletal muscle strength to physical function in older adults. Ann Behav Med 1991; 13: 91–8 Buchner D, de Lateur BJ. The importance of skeletal muscle strength to physical function in older adults. Ann Behav Med 1991; 13: 91–8
17.
go back to reference Thompson R, Crist D, Marsh M, et al. Effects of physical exercise for elderly patients with physical impairments. J Am Geriatr Soc 1988; 36: 130–5PubMed Thompson R, Crist D, Marsh M, et al. Effects of physical exercise for elderly patients with physical impairments. J Am Geriatr Soc 1988; 36: 130–5PubMed
18.
go back to reference Klitgaard H, Mantoni M, Schiaffino S, et al. Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds. Acta Physiol Scand 1990; 140: 41–54PubMedCrossRef Klitgaard H, Mantoni M, Schiaffino S, et al. Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds. Acta Physiol Scand 1990; 140: 41–54PubMedCrossRef
19.
go back to reference Pendergast D, Fisher N, Calkins E. Cardiovascular, neuromuscular and metabolic alterations with age leading to frailty. J Gerontol 1993; 48: 61–7PubMedCrossRef Pendergast D, Fisher N, Calkins E. Cardiovascular, neuromuscular and metabolic alterations with age leading to frailty. J Gerontol 1993; 48: 61–7PubMedCrossRef
21.
go back to reference Moritani T, deVries H. Potential for gross muscle hypertrophy in older men. J Gerontol 1980; 35: 672–82PubMedCrossRef Moritani T, deVries H. Potential for gross muscle hypertrophy in older men. J Gerontol 1980; 35: 672–82PubMedCrossRef
22.
go back to reference Fiatarone M, O’Neill E, Ryan N, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994; 330: 1769–75PubMedCrossRef Fiatarone M, O’Neill E, Ryan N, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994; 330: 1769–75PubMedCrossRef
23.
go back to reference Brown A, McCartney N, Sale D. Positive adaptation to weightlifting in the elderly. J Appl Physiol 1990; 69: 1725–33PubMed Brown A, McCartney N, Sale D. Positive adaptation to weightlifting in the elderly. J Appl Physiol 1990; 69: 1725–33PubMed
24.
go back to reference Charette S, McEvoy L, Pyka G, et al. Muscle hypertrophy response to resistance training in older women. J Appl Physiol 1991; 70: 1912–6PubMed Charette S, McEvoy L, Pyka G, et al. Muscle hypertrophy response to resistance training in older women. J Appl Physiol 1991; 70: 1912–6PubMed
25.
go back to reference Fiatarone M, Marks E, Ryan N, et al. High-intensity strength training in nonagenarians. JAMA 1990; 263: 3029–34PubMedCrossRef Fiatarone M, Marks E, Ryan N, et al. High-intensity strength training in nonagenarians. JAMA 1990; 263: 3029–34PubMedCrossRef
26.
go back to reference Frontera W, Meredith C, O’Reilly K, et al. Strength condition in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol 1988; 63: 1038–44 Frontera W, Meredith C, O’Reilly K, et al. Strength condition in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol 1988; 63: 1038–44
27.
go back to reference Grimby G, Aniansson A, Hedberg M, et al. Training can improve muscle strength and endurance in 78- to 84-yr-old men. J Appl Physiol 1992; 73: 2517–23PubMed Grimby G, Aniansson A, Hedberg M, et al. Training can improve muscle strength and endurance in 78- to 84-yr-old men. J Appl Physiol 1992; 73: 2517–23PubMed
28.
go back to reference Roman W, Fleckenstein J, Stray-Gundersen J, et al. Adaptations in the elbow flexors of elderly males after heavy-resistance training. J Appl Physiol 1993; 74: 750–4PubMed Roman W, Fleckenstein J, Stray-Gundersen J, et al. Adaptations in the elbow flexors of elderly males after heavy-resistance training. J Appl Physiol 1993; 74: 750–4PubMed
29.
go back to reference Staron R, Karapondo D, Kraemer W, et al. Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol 1994; 76: 1247–55PubMed Staron R, Karapondo D, Kraemer W, et al. Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol 1994; 76: 1247–55PubMed
30.
go back to reference Hurley B, Redmond R, Pratley R, Trueth M, Rogers M, Goldberg A. Effects of strength training on muscle hypertrophy and muscle cell disruption in older men. Int J Sports Med 1995; 16: 380–6CrossRef Hurley B, Redmond R, Pratley R, Trueth M, Rogers M, Goldberg A. Effects of strength training on muscle hypertrophy and muscle cell disruption in older men. Int J Sports Med 1995; 16: 380–6CrossRef
31.
go back to reference Treuth M, Ryan A, Pratley R, et al. Effects of strength training on total and regional body composition in older men. J Appl Physiol 1994; 77: 614–20PubMed Treuth M, Ryan A, Pratley R, et al. Effects of strength training on total and regional body composition in older men. J Appl Physiol 1994; 77: 614–20PubMed
32.
go back to reference Singh MA, Ding W, Manfredi TJ, et al. Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. American Journal of Physiology 1999; 277 (1 Pt 1): E135–43PubMed Singh MA, Ding W, Manfredi TJ, et al. Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. American Journal of Physiology 1999; 277 (1 Pt 1): E135–43PubMed
33.
go back to reference Metter EJ, Conwit R, Tobin J, et al. Age-associated loss of power and strength in the upper extremities in women and men. J Gerontol A Biol Sci Med Sci 1997; 52: B267–76PubMedCrossRef Metter EJ, Conwit R, Tobin J, et al. Age-associated loss of power and strength in the upper extremities in women and men. J Gerontol A Biol Sci Med Sci 1997; 52: B267–76PubMedCrossRef
34.
go back to reference Lemmer JT, Hurlbut DE, Martel GF, et al. Age and gender responses to strength training and detraining. Med Sci Sports Exerc 2000; 32: 1505–12PubMedCrossRef Lemmer JT, Hurlbut DE, Martel GF, et al. Age and gender responses to strength training and detraining. Med Sci Sports Exerc 2000; 32: 1505–12PubMedCrossRef
35.
go back to reference Tracy BL, Ivey FM, Hurlbut D, et al. Muscle quality II: effects of strength training in 65-75 year old men and women. J Appl Physiol 1999; 86 (1): 195–201PubMed Tracy BL, Ivey FM, Hurlbut D, et al. Muscle quality II: effects of strength training in 65-75 year old men and women. J Appl Physiol 1999; 86 (1): 195–201PubMed
36.
go back to reference Leong B, Kamen G, Pattern C, et al. Maximal motor discharge rates in the quadriceps muscles of older weight lifters. Med Sci Sports Exerc 1999; 31: 1638–44PubMedCrossRef Leong B, Kamen G, Pattern C, et al. Maximal motor discharge rates in the quadriceps muscles of older weight lifters. Med Sci Sports Exerc 1999; 31: 1638–44PubMedCrossRef
37.
go back to reference Patten C, Kamen G. Adaptations in human motor unit discharge behavior to strength training [abstract]. Soc Neurosci 1996; 22: 130 Patten C, Kamen G. Adaptations in human motor unit discharge behavior to strength training [abstract]. Soc Neurosci 1996; 22: 130
38.
39.
go back to reference Keen DA, Yue GH, Enoka RM. Training-related enhancement in the control of motor output in elderly humans. J Appl Physiol 1994; 77: 2648–58PubMed Keen DA, Yue GH, Enoka RM. Training-related enhancement in the control of motor output in elderly humans. J Appl Physiol 1994; 77: 2648–58PubMed
40.
go back to reference Laidlaw DH, Kornatz KW, et al. Strength training improves the steadiness of slow lengthening contractions performed by old adults. J Appl Physiol 1999; 87: 1786–95PubMed Laidlaw DH, Kornatz KW, et al. Strength training improves the steadiness of slow lengthening contractions performed by old adults. J Appl Physiol 1999; 87: 1786–95PubMed
41.
go back to reference Chen Y, Bornfeldt KE, Arner A, et al. Increase in insulin-like growth factor I in hypertrophying smooth muscle. Am J Physiol 1994; 266: 224–9 Chen Y, Bornfeldt KE, Arner A, et al. Increase in insulin-like growth factor I in hypertrophying smooth muscle. Am J Physiol 1994; 266: 224–9
42.
go back to reference Craig B, Brown R, Everhart J. Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mech Ageing Dev 1989; 49: 159–69PubMedCrossRef Craig B, Brown R, Everhart J. Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mech Ageing Dev 1989; 49: 159–69PubMedCrossRef
43.
go back to reference Kraemer W, Marchitelli L, Gordon S, et al. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 1990; 69: 1442–50PubMed Kraemer W, Marchitelli L, Gordon S, et al. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 1990; 69: 1442–50PubMed
44.
go back to reference Kraemer W, Fleck S, Dziados J, et al. Changes in hormonal concentrations after different heavy-resistance exercise protocols in women. J Appl Physiol 1993; 75: 594–604PubMed Kraemer W, Fleck S, Dziados J, et al. Changes in hormonal concentrations after different heavy-resistance exercise protocols in women. J Appl Physiol 1993; 75: 594–604PubMed
45.
go back to reference Taaffe DR, Jin IH, Vu TH, et al. Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men. J Clin Endocrinol Metab 1996; 81: 421–5PubMedCrossRef Taaffe DR, Jin IH, Vu TH, et al. Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men. J Clin Endocrinol Metab 1996; 81: 421–5PubMedCrossRef
46.
go back to reference Yarasheski KE, Campbell JA, Smith K, et al. Effect of growth hormone and resistance exercise on muscle growth in young men. Am J Physiol 1992; 262 (3 Pt 1): E261–7 Yarasheski KE, Campbell JA, Smith K, et al. Effect of growth hormone and resistance exercise on muscle growth in young men. Am J Physiol 1992; 262 (3 Pt 1): E261–7
47.
go back to reference Adams GR, McCue SA. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. J Appl Physiol 1998; 84: 1716–22PubMed Adams GR, McCue SA. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. J Appl Physiol 1998; 84: 1716–22PubMed
48.
go back to reference Czerwinski S, Martin J, Bechtel PJ. Modulation of IGF mRNA abundance during stretch-induced skeletal muscle hypertrophy and regression. J Appl Physiol 1994; 76: 2026–30PubMed Czerwinski S, Martin J, Bechtel PJ. Modulation of IGF mRNA abundance during stretch-induced skeletal muscle hypertrophy and regression. J Appl Physiol 1994; 76: 2026–30PubMed
49.
go back to reference Yang S, Alnaqeeb M, Simpson H, et al. Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch. J Anat 1997; 190: 613–22PubMedCrossRef Yang S, Alnaqeeb M, Simpson H, et al. Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch. J Anat 1997; 190: 613–22PubMedCrossRef
50.
go back to reference Coleman ME, DeMayo F, Yin KC. Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J Biol Chem 1995; 270: 12109–16PubMedCrossRef Coleman ME, DeMayo F, Yin KC. Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J Biol Chem 1995; 270: 12109–16PubMedCrossRef
51.
go back to reference Musaro A, McCullagh KJA, Naya FJ, et al. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature 1999; 400: 581–5PubMedCrossRef Musaro A, McCullagh KJA, Naya FJ, et al. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature 1999; 400: 581–5PubMedCrossRef
52.
go back to reference Napier JR, Thomas MF, Sharma M, et al. Insulin-like growth factor-1 protects myoblasts from apoptosis but requires other factors to stimulate proliferation. J Endocrinol 1999; 163: 63–8PubMedCrossRef Napier JR, Thomas MF, Sharma M, et al. Insulin-like growth factor-1 protects myoblasts from apoptosis but requires other factors to stimulate proliferation. J Endocrinol 1999; 163: 63–8PubMedCrossRef
53.
go back to reference Semsarian C, Wu MJ, Ju YK. Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway. Nature 1999; 400: 576–81PubMedCrossRef Semsarian C, Wu MJ, Ju YK. Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway. Nature 1999; 400: 576–81PubMedCrossRef
54.
go back to reference Grindland RE, Roy RR, Edgerton VR. Interactive effects of growth hormone and exercise on muscle mass in suspended rats. Am J Physiol 1994; 267: R316–22 Grindland RE, Roy RR, Edgerton VR. Interactive effects of growth hormone and exercise on muscle mass in suspended rats. Am J Physiol 1994; 267: R316–22
55.
go back to reference Larsson L. Physical training effects on muscle morphology in sedentary males at different ages. Med Sci Sports Exerc 1982; 14: 203–6PubMed Larsson L. Physical training effects on muscle morphology in sedentary males at different ages. Med Sci Sports Exerc 1982; 14: 203–6PubMed
56.
go back to reference Pyka G, Lindenberger E, Charette SL, et al. Muscle strength and fiber adaptations to a year-long resistance training program in elderly men and women. J Gerontol 1994; 49: M22–7PubMedCrossRef Pyka G, Lindenberger E, Charette SL, et al. Muscle strength and fiber adaptations to a year-long resistance training program in elderly men and women. J Gerontol 1994; 49: M22–7PubMedCrossRef
57.
go back to reference Martel GF, Roth SM, Ivey FM, et al. Effects of strength training on muscle fiber characteristics in young and older men and women [abstract]. Med Sci Sports Exerc 1999; 31: S325 Martel GF, Roth SM, Ivey FM, et al. Effects of strength training on muscle fiber characteristics in young and older men and women [abstract]. Med Sci Sports Exerc 1999; 31: S325
58.
go back to reference Hakkinen K, Newton RU, Gordon SE. Changes in muscle morphology, electromyographic activity, and force production characteristics during progressive strength training in young and oldermen. J Gerontol A Biol Sci Med Sci 1998; 53 (6): B415–23CrossRef Hakkinen K, Newton RU, Gordon SE. Changes in muscle morphology, electromyographic activity, and force production characteristics during progressive strength training in young and oldermen. J Gerontol A Biol Sci Med Sci 1998; 53 (6): B415–23CrossRef
59.
go back to reference Darr KC, Schultz E. Exercise-induced satellite cell activation in growing and mature skeletal muscle. J Appl Physiol 1987; 63: 1816–21PubMed Darr KC, Schultz E. Exercise-induced satellite cell activation in growing and mature skeletal muscle. J Appl Physiol 1987; 63: 1816–21PubMed
60.
go back to reference Snow MH. Satellite cell response in rat soleus muscle undergoing hypertrophy due to surgical ablation of synergists. Anatomical Record 1990; 227: 437–46PubMedCrossRef Snow MH. Satellite cell response in rat soleus muscle undergoing hypertrophy due to surgical ablation of synergists. Anatomical Record 1990; 227: 437–46PubMedCrossRef
61.
go back to reference Jacobs SM, Wokke JJ, Bar PR, et al. Satellite cell activation after muscle damage in young and adult rats. Anat Rec 1995; 242: 329–36PubMedCrossRef Jacobs SM, Wokke JJ, Bar PR, et al. Satellite cell activation after muscle damage in young and adult rats. Anat Rec 1995; 242: 329–36PubMedCrossRef
62.
go back to reference McCormick KM, Thomas DP. Exercise-induced satellite cell activation in senescent soleus muscle. J Appl Physiol 1992; 72: 888–93PubMedCrossRef McCormick KM, Thomas DP. Exercise-induced satellite cell activation in senescent soleus muscle. J Appl Physiol 1992; 72: 888–93PubMedCrossRef
63.
go back to reference Phelan JN, Gonyea WJ. Effect of radiation on satellite cell activity and protein expression in overloaded mammalian skeletal muscle. Anat Rec 1997; 247: 179–88PubMedCrossRef Phelan JN, Gonyea WJ. Effect of radiation on satellite cell activity and protein expression in overloaded mammalian skeletal muscle. Anat Rec 1997; 247: 179–88PubMedCrossRef
64.
go back to reference Rosenblatt JD, Yong D, Parry DJ. Satellite cell activity is required for hypertrophy of overloaded adult rat muscle. Muscle Nerve 1994; 17: 608–13PubMedCrossRef Rosenblatt JD, Yong D, Parry DJ. Satellite cell activity is required for hypertrophy of overloaded adult rat muscle. Muscle Nerve 1994; 17: 608–13PubMedCrossRef
65.
go back to reference Roth SM, Ferrell RE, Hurley BF. Strength training for the prevention and treatment of sarcopenia. J Nutr Health Aging 2000. In press Roth SM, Ferrell RE, Hurley BF. Strength training for the prevention and treatment of sarcopenia. J Nutr Health Aging 2000. In press
66.
go back to reference Greig C, Botella J, Young A. The quadriceps strength of healthy elderly people remeasured after eight years. Muscle Nerve 1993; 16: 6–10PubMedCrossRef Greig C, Botella J, Young A. The quadriceps strength of healthy elderly people remeasured after eight years. Muscle Nerve 1993; 16: 6–10PubMedCrossRef
67.
go back to reference Blair S, Kohl H, Paffenbarger R, et al. Physical fitness and all-cause mortality: a prospective study of healthy men and women. JAMA 1989; 262: 2395–401PubMedCrossRef Blair S, Kohl H, Paffenbarger R, et al. Physical fitness and all-cause mortality: a prospective study of healthy men and women. JAMA 1989; 262: 2395–401PubMedCrossRef
68.
go back to reference Powell K, Thompson P, Caspersen C, et al. Physical activity and the incidence of coronary heart disease. Ann Rev Public Health 1987; 8: 253–87CrossRef Powell K, Thompson P, Caspersen C, et al. Physical activity and the incidence of coronary heart disease. Ann Rev Public Health 1987; 8: 253–87CrossRef
69.
go back to reference Heath G, Hagberg J, Ehsani A, et al. A physiological comparison of young and older endurance athletes. J Appl Physiol 1981; 51: 634–40PubMed Heath G, Hagberg J, Ehsani A, et al. A physiological comparison of young and older endurance athletes. J Appl Physiol 1981; 51: 634–40PubMed
70.
go back to reference Frontera W, Meredith CN, O’Reilly K, et al. Strength training and determinants of V̇O2max in older men. J Appl Physiol 1990; 68: 329–33PubMed Frontera W, Meredith CN, O’Reilly K, et al. Strength training and determinants of V̇O2max in older men. J Appl Physiol 1990; 68: 329–33PubMed
71.
go back to reference Hurley B, Hagberg J, Goldberg A, et al. Resistive training can reduce coronary risk factors without altering V̇O2max or percent body fat. Med Sci Sports Exerc 1988; 20: 150–4PubMedCrossRef Hurley B, Hagberg J, Goldberg A, et al. Resistive training can reduce coronary risk factors without altering V̇O2max or percent body fat. Med Sci Sports Exerc 1988; 20: 150–4PubMedCrossRef
72.
go back to reference Hurley B, Seals D, Ehsani A, et al. Effects of high intensity strength training on cardiovascular function. Med Sci Sports Exerc 1984; 16: 483–8PubMedCrossRef Hurley B, Seals D, Ehsani A, et al. Effects of high intensity strength training on cardiovascular function. Med Sci Sports Exerc 1984; 16: 483–8PubMedCrossRef
73.
go back to reference Hickson R, Rosenkoetter M, Brown M. Strength training effects on aerobic power and short-term endurance. Med Sci Sports Exerc 1980; 12: 336–9PubMed Hickson R, Rosenkoetter M, Brown M. Strength training effects on aerobic power and short-term endurance. Med Sci Sports Exerc 1980; 12: 336–9PubMed
74.
go back to reference Marcinik E, Potts J, Schlabach G, et al. Effects of strength training on lactate threshold and endurance performance. Med Sci Sports Exerc 1991; 23: 739–43PubMed Marcinik E, Potts J, Schlabach G, et al. Effects of strength training on lactate threshold and endurance performance. Med Sci Sports Exerc 1991; 23: 739–43PubMed
75.
go back to reference Hagerman F, Walsh S, Staron R, et al. Effects of high-intensity resistance training on untrained older men. I. Strength, cardiovascular, and metabolic responses. J Gerontol A Biol Sci Med Sci 2000; 55 (7); B336–46 Hagerman F, Walsh S, Staron R, et al. Effects of high-intensity resistance training on untrained older men. I. Strength, cardiovascular, and metabolic responses. J Gerontol A Biol Sci Med Sci 2000; 55 (7); B336–46
76.
go back to reference Ades P, Ballor D, Ashikaga T, et al. Weight training improves walking endurance in healthy elderly persons. Ann Intern Med 1996; 124: 568–72PubMed Ades P, Ballor D, Ashikaga T, et al. Weight training improves walking endurance in healthy elderly persons. Ann Intern Med 1996; 124: 568–72PubMed
77.
go back to reference Parker N, Hunter G, Treuth M. Effects of strength training on cardiovascular responses during a submaximal walk an a weight-loaded walking test in older females. J Card Rehab 1996; 16: 56–62CrossRef Parker N, Hunter G, Treuth M. Effects of strength training on cardiovascular responses during a submaximal walk an a weight-loaded walking test in older females. J Card Rehab 1996; 16: 56–62CrossRef
78.
go back to reference McCartney N, McKelvie R, Martin J, et al. Weight-training-induced attenuation of the circulatory response of older males to weight lifting. J Appl Physiol 1993; 74: 1056–60PubMed McCartney N, McKelvie R, Martin J, et al. Weight-training-induced attenuation of the circulatory response of older males to weight lifting. J Appl Physiol 1993; 74: 1056–60PubMed
79.
go back to reference Wilson P, Anderson K, Harris T, et al. Determinants of change in total cholesterol and HDL-C with age: the Framingham study. J Gerontol 1994; 49 (6): M252–7PubMedCrossRef Wilson P, Anderson K, Harris T, et al. Determinants of change in total cholesterol and HDL-C with age: the Framingham study. J Gerontol 1994; 49 (6): M252–7PubMedCrossRef
80.
go back to reference Satler L, Green C, Wallace R, et al. Coronary artery disease in the elderly. Am J Cardiol 1989; 63: 245–8PubMedCrossRef Satler L, Green C, Wallace R, et al. Coronary artery disease in the elderly. Am J Cardiol 1989; 63: 245–8PubMedCrossRef
81.
go back to reference Krumholz H, Seeman T, Merrill S, et al. Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years. JAMA 1994; 272: 1335–40PubMedCrossRef Krumholz H, Seeman T, Merrill S, et al. Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years. JAMA 1994; 272: 1335–40PubMedCrossRef
82.
go back to reference Frost P, Davis B, Burlando A, et al. Serum lipids and incidence of coronary heart disease. Circulation 1996; 94: 2381–8PubMedCrossRef Frost P, Davis B, Burlando A, et al. Serum lipids and incidence of coronary heart disease. Circulation 1996; 94: 2381–8PubMedCrossRef
83.
go back to reference Schaefer E, Moussa P, Wilson W, et al. Plasma lipoproteins in healthy octogenarians: lack of reduced high density lipoprotein cholesterol levels: results from the Framingham heart study. Metabolism 1989; 38 (4): 293–6PubMedCrossRef Schaefer E, Moussa P, Wilson W, et al. Plasma lipoproteins in healthy octogenarians: lack of reduced high density lipoprotein cholesterol levels: results from the Framingham heart study. Metabolism 1989; 38 (4): 293–6PubMedCrossRef
84.
go back to reference Kohl HI, Gordon N, Scott C, et al. Musculoskeletal strength and serum lipid levels in men and women. Med Sci Sports Exerc 1992; 24: 1080–7PubMed Kohl HI, Gordon N, Scott C, et al. Musculoskeletal strength and serum lipid levels in men and women. Med Sci Sports Exerc 1992; 24: 1080–7PubMed
85.
go back to reference Tucker L, Silvester L. Strength training and hypercholesterolemia: an epidemiologic study of 8499 employed men. Am J Health Promot 1996; 11: 35–41PubMedCrossRef Tucker L, Silvester L. Strength training and hypercholesterolemia: an epidemiologic study of 8499 employed men. Am J Health Promot 1996; 11: 35–41PubMedCrossRef
86.
go back to reference Boyden T, Pamenter R, Going S, et al. Resistance exercise training is associated with decreases in serumlow-density lipoprotein cholesterol levels in premenopausal women. Arch Intern Med 1993; 153: 97–100PubMedCrossRef Boyden T, Pamenter R, Going S, et al. Resistance exercise training is associated with decreases in serumlow-density lipoprotein cholesterol levels in premenopausal women. Arch Intern Med 1993; 153: 97–100PubMedCrossRef
87.
go back to reference Fripp R, Hodgson J. Effect of resistive training on plasma lipid and lipoprotein levels in male adolescents. J Paediatr 1987; 11: 926–31CrossRef Fripp R, Hodgson J. Effect of resistive training on plasma lipid and lipoprotein levels in male adolescents. J Paediatr 1987; 11: 926–31CrossRef
88.
go back to reference Johnson C, Stone M, Lopez-S A, et al. Diet and exercise in middle-aged men. J Am Diet Assoc 1982; 81: 695–701PubMed Johnson C, Stone M, Lopez-S A, et al. Diet and exercise in middle-aged men. J Am Diet Assoc 1982; 81: 695–701PubMed
89.
go back to reference Blumenthal J, Matthews K, Fredrikson M, et al. Effects of exercise training on cardiovascular function and plasma lipid, lipoprotein, and apolipoprotein concentrations in premenopausal and postmenopausal women. Arterioscler Thromb 1991; 11: 912–7PubMedCrossRef Blumenthal J, Matthews K, Fredrikson M, et al. Effects of exercise training on cardiovascular function and plasma lipid, lipoprotein, and apolipoprotein concentrations in premenopausal and postmenopausal women. Arterioscler Thromb 1991; 11: 912–7PubMedCrossRef
90.
go back to reference Kokkinos P, Hurley B, Smutok M, et al. Strength training does not improve lipoprotein-lipid profiles inmen at risk for CHD. Med Sci Sports Exerc 1991; 123: 1134–9 Kokkinos P, Hurley B, Smutok M, et al. Strength training does not improve lipoprotein-lipid profiles inmen at risk for CHD. Med Sci Sports Exerc 1991; 123: 1134–9
91.
go back to reference Manning J, Dooly-Manning C, White K, et al. Effects of a resistance training program on lipoprotein-lipid levels in obese women. Med Sci Sports Exerc 1991; 23: 1222–6PubMed Manning J, Dooly-Manning C, White K, et al. Effects of a resistance training program on lipoprotein-lipid levels in obese women. Med Sci Sports Exerc 1991; 23: 1222–6PubMed
92.
go back to reference Rhea P, Ryan A, Nicklas B, et al. Effects of strength training with and without weight loss on lipoprotein-lipid levels in postmenopausal women. Clin Exerc Physiol 1999; 1: 138–44 Rhea P, Ryan A, Nicklas B, et al. Effects of strength training with and without weight loss on lipoprotein-lipid levels in postmenopausal women. Clin Exerc Physiol 1999; 1: 138–44
93.
go back to reference Smutok M, Reece C, Kokkinos P, et al. Aerobic vs strength training for risk factor intervention in middle-aged men at high risk for coronary heart disease. Metabolism 1993; 42: 177–84PubMedCrossRef Smutok M, Reece C, Kokkinos P, et al. Aerobic vs strength training for risk factor intervention in middle-aged men at high risk for coronary heart disease. Metabolism 1993; 42: 177–84PubMedCrossRef
94.
go back to reference Treuth M, Hunter G, Kekes-Szabo T, et al. Reduction in intra-abdominal adipose tissue after strength training in older women. J Appl Physiol 1995; 78 (4): 1425–31PubMed Treuth M, Hunter G, Kekes-Szabo T, et al. Reduction in intra-abdominal adipose tissue after strength training in older women. J Appl Physiol 1995; 78 (4): 1425–31PubMed
95.
go back to reference Hurley B. Effects of resistive training on lipoprotein-lipid profiles: a comparison to aerobic exercise training. Med Sci Sports Exerc 1989; 21: 689–93PubMed Hurley B. Effects of resistive training on lipoprotein-lipid profiles: a comparison to aerobic exercise training. Med Sci Sports Exerc 1989; 21: 689–93PubMed
96.
go back to reference Kokkinos P, Hurley B. Strength training and lipoprotein-lipid profiles: a critical analysis and recommendations for further study. Sports Med 1990; 9: 266–72PubMedCrossRef Kokkinos P, Hurley B. Strength training and lipoprotein-lipid profiles: a critical analysis and recommendations for further study. Sports Med 1990; 9: 266–72PubMedCrossRef
97.
go back to reference Despres J. Visceral obesity, insulin resistance, and dyslipidemia: contribution of endurance exercise training to the treatment of the plurimetabolic syndrome. Exerc Sport Sci Rev 1997; 25: 271–300PubMed Despres J. Visceral obesity, insulin resistance, and dyslipidemia: contribution of endurance exercise training to the treatment of the plurimetabolic syndrome. Exerc Sport Sci Rev 1997; 25: 271–300PubMed
98.
go back to reference Hersey III W, Graves J, Pollock M, et al. Endurance exercise training improves body composition and plasma insulin responses in 70-to 79-year-old men and women. Metabolism 1994; 43: 847–54PubMedCrossRef Hersey III W, Graves J, Pollock M, et al. Endurance exercise training improves body composition and plasma insulin responses in 70-to 79-year-old men and women. Metabolism 1994; 43: 847–54PubMedCrossRef
99.
go back to reference Lee A, Craig B, Lucas J, et al. The effect of endurance training, weight training and a combination of endurance and weight training upon the blood lipid profile of young male subjects. J Appl Sports Sci Res 1990; 4: 68–75 Lee A, Craig B, Lucas J, et al. The effect of endurance training, weight training and a combination of endurance and weight training upon the blood lipid profile of young male subjects. J Appl Sports Sci Res 1990; 4: 68–75
100.
go back to reference Wosornu D, Bedford D, Ballantyne D. A comparison of the effects of strength and aerobic exercise training on exercise capacity and lipids after coronary artery bypass surgery. Eur Heart J 1996; 17: 854–63PubMedCrossRef Wosornu D, Bedford D, Ballantyne D. A comparison of the effects of strength and aerobic exercise training on exercise capacity and lipids after coronary artery bypass surgery. Eur Heart J 1996; 17: 854–63PubMedCrossRef
101.
go back to reference Hagberg JM, Ferrell RE, Katzel LI, et al. Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men. Metabolism 2000; 48: 943–5CrossRef Hagberg JM, Ferrell RE, Katzel LI, et al. Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men. Metabolism 2000; 48: 943–5CrossRef
102.
go back to reference Kaplan N. Clinical hypertension. 5th ed. Baltimore (MD): Williams and Wilkins, 1990 Kaplan N. Clinical hypertension. 5th ed. Baltimore (MD): Williams and Wilkins, 1990
103.
go back to reference Stone M, Wilson G, Blessing D, et al. Cardiovascular responses to short-term Olympic style weight-training in young men. Can J Appl Sport Sci 1983; 8: 134–9PubMed Stone M, Wilson G, Blessing D, et al. Cardiovascular responses to short-term Olympic style weight-training in young men. Can J Appl Sport Sci 1983; 8: 134–9PubMed
104.
go back to reference Cononie CC, Graves JEPML. Effect of exercise training on blood pressure in 70-to 79-yr-old men and women. Med Sci Sports Exerc 1991; 23: 505–11PubMed Cononie CC, Graves JEPML. Effect of exercise training on blood pressure in 70-to 79-yr-old men and women. Med Sci Sports Exerc 1991; 23: 505–11PubMed
105.
go back to reference Hagberg JM, Blair S, Ehsani AA. Position stand: Physical activity, physical fitness, and hypertension. Med Sci Sports Exerc 1993; 25: i–x Hagberg JM, Blair S, Ehsani AA. Position stand: Physical activity, physical fitness, and hypertension. Med Sci Sports Exerc 1993; 25: i–x
106.
go back to reference Martel GF, Hurlbut MS, Lott ME, et al. Strength training normalizes resting blood pressure in 65 to 73 year-old men and women with high normal blood pressure. J Am Geriatr Soc 1999; 47: 1215–21PubMed Martel GF, Hurlbut MS, Lott ME, et al. Strength training normalizes resting blood pressure in 65 to 73 year-old men and women with high normal blood pressure. J Am Geriatr Soc 1999; 47: 1215–21PubMed
107.
go back to reference The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 1997 Nov; 157 (21): 2413–46 The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 1997 Nov; 157 (21): 2413–46
108.
go back to reference Kannel WB. Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA 1996; 275: 1571–6PubMedCrossRef Kannel WB. Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA 1996; 275: 1571–6PubMedCrossRef
109.
go back to reference National High Blood Pressure Education Pressure Education Program. National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension. Bethesda (MD): US Department of Health and Human Services, National Heart Lung, and Blood Institute, 1993: NIH publication no.: 93-2669 National High Blood Pressure Education Pressure Education Program. National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension. Bethesda (MD): US Department of Health and Human Services, National Heart Lung, and Blood Institute, 1993: NIH publication no.: 93-2669
110.
go back to reference Blumenthal J, Siegel W, Appelbaum M. Failure of exercise to reduce blood pressure in patients with mild hypertension. JAMA 1991; 266: 2098–101PubMedCrossRef Blumenthal J, Siegel W, Appelbaum M. Failure of exercise to reduce blood pressure in patients with mild hypertension. JAMA 1991; 266: 2098–101PubMedCrossRef
111.
go back to reference Davidson M. The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism 1979; 28: 687–705 Davidson M. The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism 1979; 28: 687–705
112.
go back to reference DeFronzo RA. Glucose tolerance and aging: evidence for tissue insensitivity to insulin. Diabetes 1979; 28: 1095–101PubMed DeFronzo RA. Glucose tolerance and aging: evidence for tissue insensitivity to insulin. Diabetes 1979; 28: 1095–101PubMed
113.
go back to reference Hjermann I. The metabolic cardiovascular syndrome: syndrome X, Reaven’s syndrome, insulin resistance syndrome, atherothrombogenic syndrome. J Cardiovasc Pharmacol 1992; 20 Suppl. 8: S5–10PubMed Hjermann I. The metabolic cardiovascular syndrome: syndrome X, Reaven’s syndrome, insulin resistance syndrome, atherothrombogenic syndrome. J Cardiovasc Pharmacol 1992; 20 Suppl. 8: S5–10PubMed
114.
go back to reference Stout R. Overview of the association between insulin and atherosclerosis. Metabolism 1984; 34: 7–12CrossRef Stout R. Overview of the association between insulin and atherosclerosis. Metabolism 1984; 34: 7–12CrossRef
115.
go back to reference Miller J, Pratley R, Goldberg A, et al. Strength training increases insulin action in healthy 50–65 year old men. J Appl Physiol 1994; 77: 1122–7PubMed Miller J, Pratley R, Goldberg A, et al. Strength training increases insulin action in healthy 50–65 year old men. J Appl Physiol 1994; 77: 1122–7PubMed
116.
go back to reference Craig B, Everhart J, Brown R. The influence of high-resistance training on glucose tolerance in young and elderly subjects. Mech Ageing Dev 1989; 49: 147–57PubMedCrossRef Craig B, Everhart J, Brown R. The influence of high-resistance training on glucose tolerance in young and elderly subjects. Mech Ageing Dev 1989; 49: 147–57PubMedCrossRef
117.
go back to reference Miller W, Sherman W, Ivy J. Effect of strength training on glucose tolerance and post-glucose insulin response. Med Sci Sports Exerc 1984; 16: 539–43PubMed Miller W, Sherman W, Ivy J. Effect of strength training on glucose tolerance and post-glucose insulin response. Med Sci Sports Exerc 1984; 16: 539–43PubMed
118.
go back to reference Durak E, Jovanovis-Petersol L, Peterson C. Randomized cross-over study of effect of resistance training on glycemic control, muscular strength, and cholesterol in type I diabetic men. Diabetes Care 1990; 13: 1039–42PubMedCrossRef Durak E, Jovanovis-Petersol L, Peterson C. Randomized cross-over study of effect of resistance training on glycemic control, muscular strength, and cholesterol in type I diabetic men. Diabetes Care 1990; 13: 1039–42PubMedCrossRef
119.
go back to reference Eriksson J, Taimela S, Eriksson K, et al. Resistance training in the treatment of non-insulin-dependent diabetes mellitus. Int J Sports Med 1997; 18: 242–6PubMedCrossRef Eriksson J, Taimela S, Eriksson K, et al. Resistance training in the treatment of non-insulin-dependent diabetes mellitus. Int J Sports Med 1997; 18: 242–6PubMedCrossRef
120.
go back to reference Jovanovic-Peterson L, Durak EP, Peterson CM. A twelve session exercise program and its effects on physical conditioning and glucose metabolism in type I diabetes mellitus [abstract]. Int J Sports Med 1989; 10: 377 Jovanovic-Peterson L, Durak EP, Peterson CM. A twelve session exercise program and its effects on physical conditioning and glucose metabolism in type I diabetes mellitus [abstract]. Int J Sports Med 1989; 10: 377
121.
go back to reference Peterson CM, Jones RL, DuPuis A, et al. Feasibility of improved blood glucose control in patients with insulin-dependent diabetes mellitus. Diabetes Care 1979; 2: 329–35PubMedCrossRef Peterson CM, Jones RL, DuPuis A, et al. Feasibility of improved blood glucose control in patients with insulin-dependent diabetes mellitus. Diabetes Care 1979; 2: 329–35PubMedCrossRef
122.
go back to reference Smutok MA, Reece C, Kokkinos PF, et al. Effects of exercise training modality on glucose tolerance in men with abnormal glucose regulation. Int J Sports Med 1994; 15 (6): 283–9PubMedCrossRef Smutok MA, Reece C, Kokkinos PF, et al. Effects of exercise training modality on glucose tolerance in men with abnormal glucose regulation. Int J Sports Med 1994; 15 (6): 283–9PubMedCrossRef
123.
go back to reference Eriksson J, Tuominen T, Valle S, et al. Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance? Horm Metab Res 1998; 30: 37–41PubMedCrossRef Eriksson J, Tuominen T, Valle S, et al. Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance? Horm Metab Res 1998; 30: 37–41PubMedCrossRef
124.
go back to reference Ishii T, Yamakita T, Sato T, et al. Resistance training improves insulin sensitivity in MIDDM subjects without altering maximal oxygen uptake. Diabetes Care 1998; 21: 1353–5PubMedCrossRef Ishii T, Yamakita T, Sato T, et al. Resistance training improves insulin sensitivity in MIDDM subjects without altering maximal oxygen uptake. Diabetes Care 1998; 21: 1353–5PubMedCrossRef
125.
go back to reference Ryan A, Pratley R, Goldberg A, et al. Resistive training increases insulin action in postmenopausal women. J Gerontol A Biol Sci Med Sci 1996; 51 (5): M199–205PubMedCrossRef Ryan A, Pratley R, Goldberg A, et al. Resistive training increases insulin action in postmenopausal women. J Gerontol A Biol Sci Med Sci 1996; 51 (5): M199–205PubMedCrossRef
126.
go back to reference Barret-Conner E, Wingard D, Criqui M, et al. Is border-line fasting hyperglycemia a risk factor for cardiovascular death? J Chronic Dis 1984; 37: 773–9CrossRef Barret-Conner E, Wingard D, Criqui M, et al. Is border-line fasting hyperglycemia a risk factor for cardiovascular death? J Chronic Dis 1984; 37: 773–9CrossRef
127.
go back to reference Despres J, Lamarche B, Mauriege P, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952–7PubMedCrossRef Despres J, Lamarche B, Mauriege P, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952–7PubMedCrossRef
128.
go back to reference Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism 1990; 39: 167–74PubMedCrossRef Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism 1990; 39: 167–74PubMedCrossRef
129.
go back to reference Zavaroni I, Bonoro E, Pagliara M, et al. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 1989; 320: 702–6PubMedCrossRef Zavaroni I, Bonoro E, Pagliara M, et al. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 1989; 320: 702–6PubMedCrossRef
130.
go back to reference Harris M, Hadden W, Knowler W, et al. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in US. population aged 20–74 yr. Diabetes 1987; 36: 523–34 Harris M, Hadden W, Knowler W, et al. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in US. population aged 20–74 yr. Diabetes 1987; 36: 523–34
131.
go back to reference Muller D, Elahi D, Tobin J, et al. The effect of age on insulin resistance and secretion: a review. Semin Nephrol 1996; 16: 289–98PubMed Muller D, Elahi D, Tobin J, et al. The effect of age on insulin resistance and secretion: a review. Semin Nephrol 1996; 16: 289–98PubMed
132.
go back to reference Rowe J, Minaker K, Palotta J, et al. Characterization of the insulin resistance of aging. J Clin Invest 1983; 71: 1581–7PubMedCrossRef Rowe J, Minaker K, Palotta J, et al. Characterization of the insulin resistance of aging. J Clin Invest 1983; 71: 1581–7PubMedCrossRef
133.
go back to reference Shimokata H, Muller D, Fleg J, et al. Age as independent determinant of glucose tolerance. Diabetes 1991; 40: 44–51PubMedCrossRef Shimokata H, Muller D, Fleg J, et al. Age as independent determinant of glucose tolerance. Diabetes 1991; 40: 44–51PubMedCrossRef
134.
go back to reference Broughton D, Taylor R. Review: deterioration of glucose tolerance with age: the role of insulin resistance. Age Ageing 1991; 20: 221–5PubMedCrossRef Broughton D, Taylor R. Review: deterioration of glucose tolerance with age: the role of insulin resistance. Age Ageing 1991; 20: 221–5PubMedCrossRef
135.
go back to reference Helmrich S, Ragland D, Leung R, et al. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 1991; 325: 147–52PubMedCrossRef Helmrich S, Ragland D, Leung R, et al. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 1991; 325: 147–52PubMedCrossRef
136.
go back to reference Pacini G, Valerio A, Beccaro F, et al. Insulin sensitivity and beta-cell responsivity are not decreased in elderly subjects with normal OGTT. J Am Geriatr Soc 1988; 36: 317–23PubMed Pacini G, Valerio A, Beccaro F, et al. Insulin sensitivity and beta-cell responsivity are not decreased in elderly subjects with normal OGTT. J Am Geriatr Soc 1988; 36: 317–23PubMed
137.
go back to reference Seals D, Hagberg J, Allen W, et al. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol 1984; 56: 1521–5PubMed Seals D, Hagberg J, Allen W, et al. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol 1984; 56: 1521–5PubMed
138.
go back to reference Hurley B, Hagberg J, Seals D, et al. Glucose tolerance and lipid-lipoprotein levels in middle-aged powerlifters. Clin Physiol 1987; 7: 11–9PubMedCrossRef Hurley B, Hagberg J, Seals D, et al. Glucose tolerance and lipid-lipoprotein levels in middle-aged powerlifters. Clin Physiol 1987; 7: 11–9PubMedCrossRef
139.
go back to reference Seals D, Hagberg J, Hurley B, et al. Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women. JAMA 1984; 252: 645–9PubMedCrossRef Seals D, Hagberg J, Hurley B, et al. Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women. JAMA 1984; 252: 645–9PubMedCrossRef
140.
go back to reference National Institute of Health. Consensus development conference on diet and exercise in non-insulin-dependent diabetes mellitus. Diabetes Care 1987; 10: 639–44 National Institute of Health. Consensus development conference on diet and exercise in non-insulin-dependent diabetes mellitus. Diabetes Care 1987; 10: 639–44
141.
go back to reference Koivisto V, Yki-Jarvinen H, DeFronzo R. Physical training and insulin sensitivity. Diabetes Metab Rev 1986; 1: 445–81PubMedCrossRef Koivisto V, Yki-Jarvinen H, DeFronzo R. Physical training and insulin sensitivity. Diabetes Metab Rev 1986; 1: 445–81PubMedCrossRef
142.
go back to reference Council on Exercise of the American Diabetes Association. Exercise and NIDDM. Diabetes Care 1990; 13: 785–9 Council on Exercise of the American Diabetes Association. Exercise and NIDDM. Diabetes Care 1990; 13: 785–9
143.
go back to reference Joseph LO, Farrell PA, Davey SL, et al. Effect of resistance training with or without chromium picolinate supplementation on glucose metabolism in older men and women. Metabolism 1999; 48: 546–53PubMedCrossRef Joseph LO, Farrell PA, Davey SL, et al. Effect of resistance training with or without chromium picolinate supplementation on glucose metabolism in older men and women. Metabolism 1999; 48: 546–53PubMedCrossRef
144.
go back to reference Campbell W, Crim M, Young V, et al. Increased energy requirements and changes in body composition with resistance training in older adults. Am J Clin Nutr 1994; 60: 167–75PubMed Campbell W, Crim M, Young V, et al. Increased energy requirements and changes in body composition with resistance training in older adults. Am J Clin Nutr 1994; 60: 167–75PubMed
145.
go back to reference Castro M, McCann D, Shaffrath J, et al. Peak torque per unit cross-sectional area differs between strength-trained and untrained young adults. Med Sci Sports Exerc 1995; 27 (3): 397–403PubMed Castro M, McCann D, Shaffrath J, et al. Peak torque per unit cross-sectional area differs between strength-trained and untrained young adults. Med Sci Sports Exerc 1995; 27 (3): 397–403PubMed
146.
go back to reference Bell R, Hoshizaki T. Relationships of age and sex with joint range of motion of seventeen joint actions in humans. Can J Appl Sport Sci 1981; 6: 202–6PubMed Bell R, Hoshizaki T. Relationships of age and sex with joint range of motion of seventeen joint actions in humans. Can J Appl Sport Sci 1981; 6: 202–6PubMed
148.
go back to reference Brock D, Guralnick J, Brody J. Handbook of the biology of aging. In: Schneider E, Rowe J, editors. Demography and epidemiology of aging in the US. San Diego: Academic Press, 1990: 3–23 Brock D, Guralnick J, Brody J. Handbook of the biology of aging. In: Schneider E, Rowe J, editors. Demography and epidemiology of aging in the US. San Diego: Academic Press, 1990: 3–23
149.
go back to reference Anderssen S, Hjermann I, Urdal P, et al. Improved carbohydrate metabolism after physical training and dietary intervention in individuals with the atherothrombogenic syndrome. Oslo diet and exercise study (ODES): a randomized trial. J Intern Med 1996; 240 (4): 203–9PubMedCrossRef Anderssen S, Hjermann I, Urdal P, et al. Improved carbohydrate metabolism after physical training and dietary intervention in individuals with the atherothrombogenic syndrome. Oslo diet and exercise study (ODES): a randomized trial. J Intern Med 1996; 240 (4): 203–9PubMedCrossRef
150.
go back to reference Brown M, Hagberg J. Does exercise training play a role in the treatment of essential hypertension. J Cardiovasc Risk 1995; 2: 296–302PubMedCrossRef Brown M, Hagberg J. Does exercise training play a role in the treatment of essential hypertension. J Cardiovasc Risk 1995; 2: 296–302PubMedCrossRef
151.
go back to reference Bloomfield S, Williams N, Lamb D, et al. Nonweightbearing exercise increases lumbar bone mineral density in healthy postmenopausal women. Am J Phys Med Rehab 1993; 72: 204–9CrossRef Bloomfield S, Williams N, Lamb D, et al. Nonweightbearing exercise increases lumbar bone mineral density in healthy postmenopausal women. Am J Phys Med Rehab 1993; 72: 204–9CrossRef
152.
go back to reference Lott ME, Hurlbut DE, Ryan AS, et al. Effects of strength training on glucose homeostasis in older men and women [abstract]. Med Sci Sports Exerc 1998; 30: S196 Lott ME, Hurlbut DE, Ryan AS, et al. Effects of strength training on glucose homeostasis in older men and women [abstract]. Med Sci Sports Exerc 1998; 30: S196
153.
go back to reference Zachwieja J, Toffolo G, Cobelli C, et al. Resistance exercise and growth hormone administration in older men: effects on insulin sensitivity and secretion during a stable-label intravenous glucose tolerance test. Metabolism 1996; 45: 254–60PubMedCrossRef Zachwieja J, Toffolo G, Cobelli C, et al. Resistance exercise and growth hormone administration in older men: effects on insulin sensitivity and secretion during a stable-label intravenous glucose tolerance test. Metabolism 1996; 45: 254–60PubMedCrossRef
154.
go back to reference Buemann B, Tremblay A. Effects of exercise training on abdominal obesity and related metabolic complications. Sports Med 1996; 3: 191–212CrossRef Buemann B, Tremblay A. Effects of exercise training on abdominal obesity and related metabolic complications. Sports Med 1996; 3: 191–212CrossRef
155.
go back to reference Despres J. Abdominal obesity as important component of insulin-resistance syndrome. Nutrition 1993; 9: 452–9PubMed Despres J. Abdominal obesity as important component of insulin-resistance syndrome. Nutrition 1993; 9: 452–9PubMed
156.
go back to reference Cohn S, Vaswani A, Zanzid I, et al. Changes in body chemical composition with age measured by total-body neutron activation. Am J Physiol 1976; 25: 85–95 Cohn S, Vaswani A, Zanzid I, et al. Changes in body chemical composition with age measured by total-body neutron activation. Am J Physiol 1976; 25: 85–95
157.
go back to reference Donahue R, Abbort R, Bloom E, et al. Central obesity and coronary heart disease in men. Lancet 1987; I: 822–4 Donahue R, Abbort R, Bloom E, et al. Central obesity and coronary heart disease in men. Lancet 1987; I: 822–4
158.
go back to reference Ross R, Rissanen J. Mobilization of visceral and subcutaneous adipose tissue in response to energy restriction and exercise. Am J Clin Nutr 1994; 60: 695–703PubMed Ross R, Rissanen J. Mobilization of visceral and subcutaneous adipose tissue in response to energy restriction and exercise. Am J Clin Nutr 1994; 60: 695–703PubMed
159.
go back to reference Ross R, Rissanen J, Pedwell H, et al. Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men. J Appl Physiol 1996; 81: 2445–55PubMed Ross R, Rissanen J, Pedwell H, et al. Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men. J Appl Physiol 1996; 81: 2445–55PubMed
160.
go back to reference Poehlman E, Goran M, Gardner A, et al. Determinants of decline in resting metabolic rate in aging females. Am J Physiol 1993; 264 (3 Pt 1): E450–5PubMed Poehlman E, Goran M, Gardner A, et al. Determinants of decline in resting metabolic rate in aging females. Am J Physiol 1993; 264 (3 Pt 1): E450–5PubMed
161.
go back to reference Tataranni P, Ravussin E. Variability in metabolic rate: biological sites of regulation. Int J Obes 1995; 19 Suppl. 4: S102–6 Tataranni P, Ravussin E. Variability in metabolic rate: biological sites of regulation. Int J Obes 1995; 19 Suppl. 4: S102–6
162.
go back to reference Poehlman E, Toth M, Webb G. Sodium-potassium pump activity contributes to the age-related decline in resting metabolic rate. J Clin Endocrinol Metab 1993; 76: 1054–7PubMedCrossRef Poehlman E, Toth M, Webb G. Sodium-potassium pump activity contributes to the age-related decline in resting metabolic rate. J Clin Endocrinol Metab 1993; 76: 1054–7PubMedCrossRef
163.
go back to reference Poehlman ET, Gardner AW, Ades PA, et al. Resting energy metabolism and cardiovascular disease risk in resistance-trained and aerobically trained males. Metabolism 1992; 41: 1351–60PubMedCrossRef Poehlman ET, Gardner AW, Ades PA, et al. Resting energy metabolism and cardiovascular disease risk in resistance-trained and aerobically trained males. Metabolism 1992; 41: 1351–60PubMedCrossRef
164.
go back to reference Broeder C, Burrhus K, Svanenick L, et al. The effects of either high-intensity resistance or endurance training on resting metabolic rate. Am J Clin Nutr 1992; 55: 802–10PubMed Broeder C, Burrhus K, Svanenick L, et al. The effects of either high-intensity resistance or endurance training on resting metabolic rate. Am J Clin Nutr 1992; 55: 802–10PubMed
165.
go back to reference Pratley R, Nicklas B, Rubin M, et al. Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men. J Appl Physiol 1994; 76: 133–7PubMedCrossRef Pratley R, Nicklas B, Rubin M, et al. Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men. J Appl Physiol 1994; 76: 133–7PubMedCrossRef
166.
go back to reference Van Etten L, Westerterp K, Verstaooebm FT. Effect of weight-training on energy expenditure and substrate utilization during sleep. Med Sci Sports Exerc 1994; 27: 188–93 Van Etten L, Westerterp K, Verstaooebm FT. Effect of weight-training on energy expenditure and substrate utilization during sleep. Med Sci Sports Exerc 1994; 27: 188–93
167.
go back to reference Van Etten L, Westertep K, Vestappen F, et al. Effect of an 18-wk weight-training program on energy expenditure and physical activity. J Appl Physiol 1997; 82: 298–304PubMed Van Etten L, Westertep K, Vestappen F, et al. Effect of an 18-wk weight-training program on energy expenditure and physical activity. J Appl Physiol 1997; 82: 298–304PubMed
168.
go back to reference Cullinen K, Caldwell M. Weight training increases fat-free mass and strength in untrained young women. J Am Diet Assoc 1998; 98: 414–8PubMedCrossRef Cullinen K, Caldwell M. Weight training increases fat-free mass and strength in untrained young women. J Am Diet Assoc 1998; 98: 414–8PubMedCrossRef
169.
go back to reference Ryan A, Pratley R, Elahi D, et al. Resistive training increases fat-free mass and maintains RMR despite weight loss in postmenopausal women. J Appl Physiol 1995; 79: 818–23PubMed Ryan A, Pratley R, Elahi D, et al. Resistive training increases fat-free mass and maintains RMR despite weight loss in postmenopausal women. J Appl Physiol 1995; 79: 818–23PubMed
170.
go back to reference Taaffe D, Pruitt L, Reim J, et al. Effect of sustained resistance training on basal metabolic rate in older women. J Am Geriatr Soc 1995; 43: 465–71PubMed Taaffe D, Pruitt L, Reim J, et al. Effect of sustained resistance training on basal metabolic rate in older women. J Am Geriatr Soc 1995; 43: 465–71PubMed
171.
go back to reference Treuth M, Hunter G, Weinsier R, et al. Energy expenditure and substrate utilization in older women after strength training: 24-h calorimeter results. J Appl Physiol 1995; 78 (6): 2140–6PubMed Treuth M, Hunter G, Weinsier R, et al. Energy expenditure and substrate utilization in older women after strength training: 24-h calorimeter results. J Appl Physiol 1995; 78 (6): 2140–6PubMed
172.
go back to reference Ballor DL, Harvey-Berino JR, Ades PA, et al. Contrasting effects of resistance and aerobic training on body composition and metabolism after diet-induced weight loss. Metabolism 1996; 45: 179–83PubMedCrossRef Ballor DL, Harvey-Berino JR, Ades PA, et al. Contrasting effects of resistance and aerobic training on body composition and metabolism after diet-induced weight loss. Metabolism 1996; 45: 179–83PubMedCrossRef
173.
go back to reference Rall LC, Meydani SN, Kehayias JJ, et al. The effect progressive resistance training in rheumatoid arthritis: increased strength with changes in energy balance or body composition. Arthritis Rheum 1996; 39 (3): 415–26PubMedCrossRef Rall LC, Meydani SN, Kehayias JJ, et al. The effect progressive resistance training in rheumatoid arthritis: increased strength with changes in energy balance or body composition. Arthritis Rheum 1996; 39 (3): 415–26PubMedCrossRef
174.
go back to reference Bryner RW, Ullrich IH, Sauers J, et al. Effects of resistance vs aerobic training combined with an 800 calorie liquid diet on lean body mass and resting metabolic rate. J Am Col Nutr 1999; 18: 115–21 Bryner RW, Ullrich IH, Sauers J, et al. Effects of resistance vs aerobic training combined with an 800 calorie liquid diet on lean body mass and resting metabolic rate. J Am Col Nutr 1999; 18: 115–21
175.
go back to reference Nelson M, Fiatarone M, Morganti C, et al. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures: a randomized controlled trial. JAMA 1994; 272: 1909–14PubMedCrossRef Nelson M, Fiatarone M, Morganti C, et al. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures: a randomized controlled trial. JAMA 1994; 272: 1909–14PubMedCrossRef
176.
go back to reference Ross R, Pedwell H, Rissanen J. Effects of energy restriction and exercise on skeletal muscle and adipose tissue in women as measured by magnetic resonance imaging. Am J Clin Nutr 1995; 61: 1179–85PubMed Ross R, Pedwell H, Rissanen J. Effects of energy restriction and exercise on skeletal muscle and adipose tissue in women as measured by magnetic resonance imaging. Am J Clin Nutr 1995; 61: 1179–85PubMed
177.
go back to reference Lemmer JT, Ivey FM, Ryan AS, et al. Effect of strength training on RMR and physical activity: age and gender comparisons. Med Sci Sports Exerc 2000. In press Lemmer JT, Ivey FM, Ryan AS, et al. Effect of strength training on RMR and physical activity: age and gender comparisons. Med Sci Sports Exerc 2000. In press
178.
go back to reference Cummings S, Kelsey J, Nevitt M. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 1985; 7: 178–205PubMed Cummings S, Kelsey J, Nevitt M. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 1985; 7: 178–205PubMed
179.
go back to reference Lindsay R. Osteoporosis. Chicago (IL): National Osteoporosis Foundation, 1992 Lindsay R. Osteoporosis. Chicago (IL): National Osteoporosis Foundation, 1992
180.
go back to reference Zimmermann CL, Smidt GL, Brooks JS, et al. Relationship of extremity muscle torque and bone mineral density in postmenopausal women. Phys Ther 1990; 70: 302–9PubMed Zimmermann CL, Smidt GL, Brooks JS, et al. Relationship of extremity muscle torque and bone mineral density in postmenopausal women. Phys Ther 1990; 70: 302–9PubMed
181.
go back to reference Ryan AS, Treuth MS, Hunter GR, et al. Resistive training maintains bone mineral density in postmenopausal women. Calcif Tissue Int 1998; 62: 295–9PubMedCrossRef Ryan AS, Treuth MS, Hunter GR, et al. Resistive training maintains bone mineral density in postmenopausal women. Calcif Tissue Int 1998; 62: 295–9PubMedCrossRef
182.
go back to reference Calmels P, Vico L, Alexandre C, et al. Cross-sectional study of muscle strength and bone mineral density in a population of 106 women between the ages of 44 and 87 years: relationship with age and menopause. Eur J Appl Physiol 1995; 70: 180–6CrossRef Calmels P, Vico L, Alexandre C, et al. Cross-sectional study of muscle strength and bone mineral density in a population of 106 women between the ages of 44 and 87 years: relationship with age and menopause. Eur J Appl Physiol 1995; 70: 180–6CrossRef
183.
go back to reference Hughes V, Frontera W, Dallal G, et al. Muscle strength and body composition: associations with bone density in older subjects. Med Sci Sports Exerc 1995; 27: 967–74PubMedCrossRef Hughes V, Frontera W, Dallal G, et al. Muscle strength and body composition: associations with bone density in older subjects. Med Sci Sports Exerc 1995; 27: 967–74PubMedCrossRef
184.
go back to reference Aloia JF, Vaswani A, Flaster MaR, et al. To what extent is bone mass determined by fat-free or fat mass? Am J Clin Nutr 1995; 61: 1110–4PubMed Aloia JF, Vaswani A, Flaster MaR, et al. To what extent is bone mass determined by fat-free or fat mass? Am J Clin Nutr 1995; 61: 1110–4PubMed
185.
go back to reference Bevier W, Wiswell R, Pyka G, et al. Relationship of body composition, muscle strength, and aerobic capacity to bone mineral density in older men and women. J Bone Miner Res 1989; 4: 421–32PubMedCrossRef Bevier W, Wiswell R, Pyka G, et al. Relationship of body composition, muscle strength, and aerobic capacity to bone mineral density in older men and women. J Bone Miner Res 1989; 4: 421–32PubMedCrossRef
186.
go back to reference Haapasalo H, Kannus P, Sievanen H, et al. Long-term unilateral loading and bone mineral density and content in female squash players. Calcif Tissue Int 1994; 54: 249–55PubMedCrossRef Haapasalo H, Kannus P, Sievanen H, et al. Long-term unilateral loading and bone mineral density and content in female squash players. Calcif Tissue Int 1994; 54: 249–55PubMedCrossRef
187.
go back to reference Karlsson M, Vergnaud P, Delmas P, et al. Indicators of bone formation in weight lifters. Calcif Tissue Int 1995; 56: 177–80PubMedCrossRef Karlsson M, Vergnaud P, Delmas P, et al. Indicators of bone formation in weight lifters. Calcif Tissue Int 1995; 56: 177–80PubMedCrossRef
188.
go back to reference Notelovitz M, Martin D, Probart C. Estrogen therapy and variable-resistance weight training increase bone mineral in surgically menopausal women. J Bone Miner Res 1991; 6: 583–90PubMedCrossRef Notelovitz M, Martin D, Probart C. Estrogen therapy and variable-resistance weight training increase bone mineral in surgically menopausal women. J Bone Miner Res 1991; 6: 583–90PubMedCrossRef
189.
go back to reference Pruitt LA, Jackson RD, Bartels RL, et al. Weight training effects on bone mineral density in early postmenopausal women. J Bone Miner Res 1992; 7: 179–85PubMedCrossRef Pruitt LA, Jackson RD, Bartels RL, et al. Weight training effects on bone mineral density in early postmenopausal women. J Bone Miner Res 1992; 7: 179–85PubMedCrossRef
190.
go back to reference Menkes A, Mazel S, Redmond R, et al. Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. J Appl Physiol 1993; 74: 2478–84PubMed Menkes A, Mazel S, Redmond R, et al. Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. J Appl Physiol 1993; 74: 2478–84PubMed
191.
go back to reference Ryan A, Treuth M, Rubin M, et al. Effects of strength training on bone mineral density: hormonal and bone turnover relationships. J Appl Physiol 1994; 77 (4): 1678–84PubMed Ryan A, Treuth M, Rubin M, et al. Effects of strength training on bone mineral density: hormonal and bone turnover relationships. J Appl Physiol 1994; 77 (4): 1678–84PubMed
192.
go back to reference Snow-Harter C, Bouxsein M, Lewis B, et al. Effects of resistance and endurance exercise on bone mineral status of young women. J Bone Miner Res 1992; 7: 761–9PubMedCrossRef Snow-Harter C, Bouxsein M, Lewis B, et al. Effects of resistance and endurance exercise on bone mineral status of young women. J Bone Miner Res 1992; 7: 761–9PubMedCrossRef
193.
go back to reference Lohman T, Going S, Pamenter R, et al. Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res 1995; 10: 1015–24PubMedCrossRef Lohman T, Going S, Pamenter R, et al. Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res 1995; 10: 1015–24PubMedCrossRef
194.
go back to reference Gleeson P, Protas E, LeBlanc A, et al. Effects of weight lifting on bone mineral density in premenopausal women. J Bone Miner Res 1990; 5: 153–8PubMedCrossRef Gleeson P, Protas E, LeBlanc A, et al. Effects of weight lifting on bone mineral density in premenopausal women. J Bone Miner Res 1990; 5: 153–8PubMedCrossRef
195.
go back to reference Rockwell JC, Sorensen AM, Baker S, et al. Weight training decreases vertebral bone density in premenopausal women: a prospective study. J Clin Endocrinol Metab 1990; 71: 988–93PubMedCrossRef Rockwell JC, Sorensen AM, Baker S, et al. Weight training decreases vertebral bone density in premenopausal women: a prospective study. J Clin Endocrinol Metab 1990; 71: 988–93PubMedCrossRef
196.
go back to reference Yarasheski KE, Campbell JA, Kohrt WM. Effect of resistance exercise and growth hormone on bone density in older men. Clin Endocrinol 1997; 47: 223–9CrossRef Yarasheski KE, Campbell JA, Kohrt WM. Effect of resistance exercise and growth hormone on bone density in older men. Clin Endocrinol 1997; 47: 223–9CrossRef
197.
go back to reference Courtney A, Wachtel E, Myers E, et al. Effects of loading rate on strength of the proximal femur. Calcif Tissue Int 1994; 55: 53–8PubMedCrossRef Courtney A, Wachtel E, Myers E, et al. Effects of loading rate on strength of the proximal femur. Calcif Tissue Int 1994; 55: 53–8PubMedCrossRef
198.
go back to reference Davis MA, Ettinger WH, Neuhaus JM, et al. Knee osteoarthritis and physical functioning: evidence from the NHANES I epidemiologic follow-up study. J Rheumatol 1990; 18: 591–8 Davis MA, Ettinger WH, Neuhaus JM, et al. Knee osteoarthritis and physical functioning: evidence from the NHANES I epidemiologic follow-up study. J Rheumatol 1990; 18: 591–8
199.
go back to reference Gilliland B. Degenerative joint disease. In: Eugene B, Isselbacher K, Petersdorf R, et al., editors. Harrison’s principles of internal medicine. New York: McGraw Hill Book Company, 1987: 1456–8 Gilliland B. Degenerative joint disease. In: Eugene B, Isselbacher K, Petersdorf R, et al., editors. Harrison’s principles of internal medicine. New York: McGraw Hill Book Company, 1987: 1456–8
200.
go back to reference Ekdahl C, Andersson S, Svensson B. Muscle function of the lower extremities in rheumatoid arthritis and osteoarthrosis: a descriptive study in patients in a primary health care district. J Clin Epidemiol 1989; 42: 947–54PubMedCrossRef Ekdahl C, Andersson S, Svensson B. Muscle function of the lower extremities in rheumatoid arthritis and osteoarthrosis: a descriptive study in patients in a primary health care district. J Clin Epidemiol 1989; 42: 947–54PubMedCrossRef
201.
go back to reference O’Reilly S, Jones A, Doherty M. Muscle weakness in osteoarthritis. Curr Opin Rheumatol 1997; 9: 259-62PubMedCrossRef O’Reilly S, Jones A, Doherty M. Muscle weakness in osteoarthritis. Curr Opin Rheumatol 1997; 9: 259-62PubMedCrossRef
202.
go back to reference Fisher NM, Pendergast DR. Effects of a muscle exercise program on exercise capacity in subjects with osteoarthritis. Arch Phys Med Rehab 1994; 75: 792–7 Fisher NM, Pendergast DR. Effects of a muscle exercise program on exercise capacity in subjects with osteoarthritis. Arch Phys Med Rehab 1994; 75: 792–7
203.
go back to reference Pothier B, Allen M. Kinesiology and the degenerative joint. Rheum Dis Clin North Am 1991; 16: 989–1002 Pothier B, Allen M. Kinesiology and the degenerative joint. Rheum Dis Clin North Am 1991; 16: 989–1002
204.
go back to reference Adler S. Self care in the management of the degenerative knee joint. Physiotherapy 1985; 71: 58–60 Adler S. Self care in the management of the degenerative knee joint. Physiotherapy 1985; 71: 58–60
205.
go back to reference Chamberlain M, Care G, Harfield B. Physiotherapy in osteoarthritis of the knees: a controlled trial of hospital versus home exercises. Int Rehab Med 1982; 4: 101–6 Chamberlain M, Care G, Harfield B. Physiotherapy in osteoarthritis of the knees: a controlled trial of hospital versus home exercises. Int Rehab Med 1982; 4: 101–6
206.
go back to reference Marks R. The effect of isometric quadriceps strength training in mid-range for osteoarthritis of the knee. Arthritis Care Res 1993; 6: 52–6PubMedCrossRef Marks R. The effect of isometric quadriceps strength training in mid-range for osteoarthritis of the knee. Arthritis Care Res 1993; 6: 52–6PubMedCrossRef
207.
go back to reference Quirk A, Newman R, Newman K. An evaluation of interterential therapy, shortwave diathermy and exercise in the treatment of osteo-arthritis of the knee. Physiotherapy 1985; 71: 55–7 Quirk A, Newman R, Newman K. An evaluation of interterential therapy, shortwave diathermy and exercise in the treatment of osteo-arthritis of the knee. Physiotherapy 1985; 71: 55–7
208.
go back to reference Marks R. Quadriceps strength training for osteo-arthritis of the knee: A literature review and analysis. Physiotherapy 1993; 79: 13–8CrossRef Marks R. Quadriceps strength training for osteo-arthritis of the knee: A literature review and analysis. Physiotherapy 1993; 79: 13–8CrossRef
209.
go back to reference Schilke JM, Johnson GO, Housh TJ, et al. Effects of muscle-strength training on the functional status of patients with osteoarthritis of the knee joint. Nurs Res 1996; 45: 68–72PubMedCrossRef Schilke JM, Johnson GO, Housh TJ, et al. Effects of muscle-strength training on the functional status of patients with osteoarthritis of the knee joint. Nurs Res 1996; 45: 68–72PubMedCrossRef
210.
go back to reference Ettinger WJ, Burns R, Messier S, et al. Arandomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. JAMA 1997; 277: 25–31PubMedCrossRef Ettinger WJ, Burns R, Messier S, et al. Arandomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. JAMA 1997; 277: 25–31PubMedCrossRef
211.
go back to reference Rogind H, Bibow-Nielson B, Jensen B, et al. The effects of a physical training program on patients with osteoarthritis of the knees. Arch Phys Med Rehab 1998; 79: 1421–7CrossRef Rogind H, Bibow-Nielson B, Jensen B, et al. The effects of a physical training program on patients with osteoarthritis of the knees. Arch Phys Med Rehab 1998; 79: 1421–7CrossRef
212.
213.
go back to reference Bassey E, Morgan K, Dallosso H, et al. Flexibility of the shoulder joint measured as range of abduction in a large representative sample of men and women over 65 years of age. Eur J Appl Physiol 1989; 58: 353–60CrossRef Bassey E, Morgan K, Dallosso H, et al. Flexibility of the shoulder joint measured as range of abduction in a large representative sample of men and women over 65 years of age. Eur J Appl Physiol 1989; 58: 353–60CrossRef
214.
go back to reference Germain N, Blaire S. Variability of shoulder flexion with age, activity and sex. Am Correct Ther J 1983; 37 (6): 156-60PubMed Germain N, Blaire S. Variability of shoulder flexion with age, activity and sex. Am Correct Ther J 1983; 37 (6): 156-60PubMed
215.
go back to reference Bergstrom G, Aniansson A. Functional consequences of joint impairment at age 79. Scand J Rehab Med 1985; 17: 183–90 Bergstrom G, Aniansson A. Functional consequences of joint impairment at age 79. Scand J Rehab Med 1985; 17: 183–90
216.
go back to reference Gehlsen G, Whaley M. Falls in the elderly: part II, balance, strength, and flexibility. Arch Phys Med Rehab 1990; 71: 739–41 Gehlsen G, Whaley M. Falls in the elderly: part II, balance, strength, and flexibility. Arch Phys Med Rehab 1990; 71: 739–41
217.
go back to reference Chapman E, deVries H, Swezey R. Joint stiffness: effects of exercise on young and oldmen. J Gerontol 1972; 27 (2): 218–21PubMedCrossRef Chapman E, deVries H, Swezey R. Joint stiffness: effects of exercise on young and oldmen. J Gerontol 1972; 27 (2): 218–21PubMedCrossRef
218.
go back to reference Voorhips L, Lemmunk K, Van Heuvellon M, et al. The physical condition of elderly women differing in habitual physical activity. Med Sci Sports Exerc 1993; 25: 1152–7 Voorhips L, Lemmunk K, Van Heuvellon M, et al. The physical condition of elderly women differing in habitual physical activity. Med Sci Sports Exerc 1993; 25: 1152–7
219.
go back to reference Kligman E, Pepin E. Prescribing physical activity for older patients. Geriatrics 1992; 47: 33–47PubMed Kligman E, Pepin E. Prescribing physical activity for older patients. Geriatrics 1992; 47: 33–47PubMed
220.
go back to reference Lombardi V. Beginning weight training. Dubuque: WC Brown Publishers, 1989 Lombardi V. Beginning weight training. Dubuque: WC Brown Publishers, 1989
221.
go back to reference Stone M, Fleck S, Triplett N, et al. Health and performance related potential of resistance training. Sports Med 1991; 11: 210–31PubMedCrossRef Stone M, Fleck S, Triplett N, et al. Health and performance related potential of resistance training. Sports Med 1991; 11: 210–31PubMedCrossRef
222.
go back to reference Girouard C, Hurley B. Does strength training inhibit gains in range of motion from flexibility training in older adults? Med Sci Sports Exerc 1995; 27 (10): 1444–9PubMed Girouard C, Hurley B. Does strength training inhibit gains in range of motion from flexibility training in older adults? Med Sci Sports Exerc 1995; 27 (10): 1444–9PubMed
223.
go back to reference Gardner G. Effect of isometric and isotonic exercise on joint motion. Arch Phys Med Rehab 1966; 47: 24–30 Gardner G. Effect of isometric and isotonic exercise on joint motion. Arch Phys Med Rehab 1966; 47: 24–30
224.
go back to reference Weltman A, Janney C, Rians C, et al. The effects of hydraulic resistance strength training in pre-pubertal males. Med Sci Sports Exerc 1986; 18: 629–38PubMed Weltman A, Janney C, Rians C, et al. The effects of hydraulic resistance strength training in pre-pubertal males. Med Sci Sports Exerc 1986; 18: 629–38PubMed
225.
go back to reference Massey B, Chauder N. Effects of systematic, heavy resistive exercise on range of joint movement in young male adults. Res Q 1956; 27: 41–51 Massey B, Chauder N. Effects of systematic, heavy resistive exercise on range of joint movement in young male adults. Res Q 1956; 27: 41–51
226.
go back to reference Marcinik E, Hodgdon J, Mittleman K, et al. Aerobic/calisthenic and aerobic/circuit weight training programs for Navy men: a comparative study. Med Sci Sports Exerc 1985; 17: 482–7PubMedCrossRef Marcinik E, Hodgdon J, Mittleman K, et al. Aerobic/calisthenic and aerobic/circuit weight training programs for Navy men: a comparative study. Med Sci Sports Exerc 1985; 17: 482–7PubMedCrossRef
227.
go back to reference Morey M, Cowper P, Fuessner J, et al. Evaluation of a supervised exercise program in a geriatric population. J Am Geriatr Soc 1989; 37: 348–54PubMed Morey M, Cowper P, Fuessner J, et al. Evaluation of a supervised exercise program in a geriatric population. J Am Geriatr Soc 1989; 37: 348–54PubMed
228.
go back to reference Raab D, Agre J, McAdam M, et al. Light resistance and stretching exercise in elderly women: effect upon flexibility. Arch Phys Med Rehab 1988; 69: 268–72 Raab D, Agre J, McAdam M, et al. Light resistance and stretching exercise in elderly women: effect upon flexibility. Arch Phys Med Rehab 1988; 69: 268–72
229.
go back to reference American College of Sports Medicine. Exercise and physical activity for older adults. Med Sci Sports Exerc 1998; 30: 992–1009CrossRef American College of Sports Medicine. Exercise and physical activity for older adults. Med Sci Sports Exerc 1998; 30: 992–1009CrossRef
230.
go back to reference Myers A, Young Y, Langlois J. Prevention of falls in the elderly. Bone 1996; 18 (1 Suppl.): 87S–101SPubMedCrossRef Myers A, Young Y, Langlois J. Prevention of falls in the elderly. Bone 1996; 18 (1 Suppl.): 87S–101SPubMedCrossRef
231.
go back to reference Jozsi AC, Campbell WW, Joseph L, et al. Changes in power with resistance training in older and younger men and women. J Gerontol A Biol Sci Med Sci 1999; 54 (11): M591–6PubMedCrossRef Jozsi AC, Campbell WW, Joseph L, et al. Changes in power with resistance training in older and younger men and women. J Gerontol A Biol Sci Med Sci 1999; 54 (11): M591–6PubMedCrossRef
Metadata
Title
Strength Training in the Elderly
Effects on Risk Factors for Age-Related Diseases
Authors
Dr Ben F. Hurley
Stephen M. Roth
Publication date
01-10-2000
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 4/2000
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.2165/00007256-200030040-00002

Other articles of this Issue 4/2000

Sports Medicine 4/2000 Go to the issue

Injury Clinic

Commotio Cordis