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Journal of Inflammation
Published in: Journal of Inflammation 1/2013

Open Access 01-08-2013 | Poster presentation

Strategies to improve lung absorption of intratracheally administered compounds in Drug Discovery

Authors: Elena Calama, Montserrat Vives, Isabel Ramis, Sonia Espinosa, Juan Pérez, Josep Maria Huerta, Jorge De Alba, Peter Eichhorn

Published in: Journal of Inflammation | Special Issue 1/2013

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Excerpt

The key factors governing the absorption of drugs from the lungs are deposition pattern, dissolution rate, solubility and permeability. Whereas the thin epithelium in the respiratory airways is generally considered to constitute a minor barrier in the overall absorption process, the other two components depend, among other parameters, on the formulation and the particle size. This is of particular importance for compounds with very low solubility. …
Metadata
Title
Strategies to improve lung absorption of intratracheally administered compounds in Drug Discovery
Authors
Elena Calama
Montserrat Vives
Isabel Ramis
Sonia Espinosa
Juan Pérez
Josep Maria Huerta
Jorge De Alba
Peter Eichhorn
Publication date
01-08-2013
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue Special Issue 1/2013
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/1476-9255-10-S1-P35

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Developed by: Springer Medicine

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