Published in:
01-10-2018 | Letter to the Editor
Statins as potential agents for the prevention and treatment of osteoporosis
Authors:
F Kaleağasıoğlu, E Olcay, R Onur
Published in:
Endocrine
|
Issue 1/2018
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Excerpt
We read with interest the article entitled “Comparative impact of systemic delivery of atorvastatin, simvastatin, and lovastatin on bone mineral density of the ovariectomized rats” which was recently published by Shahrezaee and co-workers [
1]. In this study, oral treatment with simvastatin (25 mg/kg/day), and lovastatin (20 mg/kg/ day) for 60 days significantly increased serum calcium level, expression of osteogenic genes, trabecular bone mineral density (BMD), the bone volume/total volume, and bone thickness in ovariectomized (OVX) rats. Both biomechanical parameters, ultimate load and stiffness, in femur and vertebra were significantly improved only by simvastatin versus the OVX group. …
