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Journal of General Internal Medicine
Published in: Journal of General Internal Medicine 11/2015

01-11-2015 | Editorial

Statins and Diabetes: The Plot Thickens

Authors: Giacomo Gastaldi, MD, Jacques Philippe, MD

Published in: Journal of General Internal Medicine | Issue 11/2015

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Excerpt

Statins have now been used in clinical practice for more than 20 years, and are the cornerstone of primary and secondary prevention of cardiovascular disease. The increased risk of new-onset type 2 diabetes in patients treated with statins has been well established by large meta-analyses of randomized controlled trials and observational studies.1 , 2 …
Literature
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Sattar N, Preiss D, Murray HM, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomized statin trials. Lancet. 2010;27:735–742.CrossRef
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Dormuth CR, Filion KB, Parerson JM, et al. Higher potency statins and the risk of the diabetes: multicentre, observational study of administrative databases. BMJ. 2014;348:g3244.PubMedCentralCrossRefPubMed
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Preiss D, Kondapally Seshasai SR, Welsh P, et al. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA. 2011;305(24):2556–2564.CrossRefPubMed
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Cederberg H, Stancakova A, Yaluri N, et al. Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort. Diabetologia. 2015;s00125-015:3528–5.
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Erqou S, Lee CC, Adler AI. Statins and glycaemic control in individuals with diabetes: a systematic review and meta-analysis. Diabetologia. 2014;57:2444–2452.CrossRefPubMed
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Swerdlow D, Preiss D, Kuchenbaecker KB, et al. HMG-coenzyme a reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomized trials. Lancet. 2014;S0140-6736(14):61183–1.
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Radford NB, DeFina LF, Barlow CE, et al. Effect of fitness on incident diabetes from statin use in primary prevention. Atherosclerosis. 2015;239:43–49.CrossRefPubMed
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Mansi I, Frei CR, Wang CP, Mortensen EM. Statins and new-onset diabetes mellitus and diabetic complications: a retrospective cohort study of US healthy adults. J Gen Int Med doi: 10.​1007/​s11606-015-3335-1
Metadata
Title
Statins and Diabetes: The Plot Thickens
Authors
Giacomo Gastaldi, MD
Jacques Philippe, MD
Publication date
01-11-2015
Publisher
Springer US
Published in
Journal of General Internal Medicine / Issue 11/2015
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-015-3399-y

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