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European Journal of Nuclear Medicine and Molecular Imaging

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01-04-2009 | Original Article

Standardization of the heart-to-mediastinum ratio of ¹²³I-labelled-metaiodobenzylguanidine uptake using the dual energy window method: feasibility of correction with different camera–collimator combinations

Authors: Shinro Matsuo, Kenichi Nakajima, Koichi Okuda, Masaya Kawano, Takehiro Ishikawa, Tetsuo Hosoya, Junichi Taki, Seigo Kinuya

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 4/2009

Abstract

Background

Although the heart-to-mediastinum (H/M) ratio in a planar image has been used for practical quantification in ¹²³I-metaiodobenzylguanidine (MIBG) imaging, standardization of the parameter is not yet established. We hypothesized that the value of the H/M ratio could be standardized to the various camera–collimator combinations.

Methods and results

Standard phantoms consisting of the heart and mediastinum were made. A low-energy high-resolution (LEHR) collimator and a medium-energy (ME) collimator were used. We examined multi-window correction methods with ¹²³I- dual-window (IDW) acquisition, and planar images were obtained with IDW correction and the LEHR collimator. The images were obtained using the following gamma camera systems: GCA 9300A (Toshiba, Tokyo), E.CAM Signature (Toshiba/Siemens, Tokyo) and Varicam (GE, Tokyo). Cardiac phantom studies demonstrated that contamination of the H/M count ratio was greater with the LEHR collimator and least with the ME collimator. The corrected H/M ratio with the LEHR collimator was similar to that with ME collimators. The uncorrected H/M ratio with the ME collimator was linearly related to the H/M ratio with IDW correction with the LEHR collimator. The relationship between the uncorrected H/M ratios determined with the LEHR (E.CAM) and the ME collimators was y = 0.56x + 0.49, where y = H/M ratio with the E.CAM and x = H/M ratio with the ME collimator. The average normal values for the low-energy collimator (n=18) were 2.2±0.2 (initial H/M ratio) and 2.42±0.2 (delayed H/M ratio), and for the low/medium-energy (LME) collimator (n=14) were 2.63±0.25 (initial H/M ratio) and 2.87±0.19 (delayed H/M ratio). H/M ratios in previous clinical studies using LEHR collimators are comparable to those with ME collimators.

Conclusion

The IDW-corrected H/M ratios determined with the LEHR collimator were similar to those determined with the ME collimator. This finding could make it possible to standardize the H/M ratio in planar imaging among various collimators in the clinical setting.

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Title: Standardization of the heart-to-mediastinum ratio of 123I-labelled-metaiodobenzylguanidine uptake using the dual energy window method: feasibility of correction with different camera–collimator combinations
Authors: Shinro Matsuo
Kenichi Nakajima
Koichi Okuda
Masaya Kawano
Takehiro Ishikawa
Tetsuo Hosoya
Junichi Taki
Seigo Kinuya
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 4/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-0971-2

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Springer Medicine

Standardization of the heart-to-mediastinum ratio of ¹²³I-labelled-metaiodobenzylguanidine uptake using the dual energy window method: feasibility of correction with different camera–collimator combinations

Abstract

Background

Methods and results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods and results

Conclusion

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