Top

Journal of Cardiothoracic Surgery

Published in:

Open Access 01-12-2021 | ST-Segment Elevation Myocardial Infarction | Research article

Study on the safety and effectiveness of drug-coated balloons in patients with acute myocardial infarction

Authors: Xiaojiao Hao, Damin Huang, Zhaoxia Wang, Jinchun Zhang, Hongqiang Liu, Yingmin Lu

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

Background

Drug-coated balloon (DCB) is a new technology that has emerged in recent years and has been proven to be effective and safe in the treatment of in-stent restenosis. The purpose of this article is to observe the safety and effectiveness of drug-coated balloons in patients with acute myocardial infarction.

Method

We selected 80 patients admitted to the hospital for STEMI from January 2018 to December 2019. The subjects were randomly divided into a Yinyi (Liaoning) Biotech Bingo Drug Coated Balloon treatment group (balloon group, n = 38) and a drug-eluting stent (DES) treatment group (stent group, n = 42). Patients were followed up to understand the incidence of major adverse cardiovascular events (MACE) at 1 month, 6 months and 1 year after surgery. Coronary angiography was rechecked 1 year after surgery to understand the late lumen loss (LLL) in the two groups.

Result

During the one-year follow-up, the LLL of the target lesion in the balloon group was -0.12±0.46 mm, while the target lesion in the stent group was 0.14±0.37 mm ( P <0.05). Within 1 year, the incidence of MACE in the balloon group was 11%, while the incidence of MACE in the stent group was 12%. There was no significant difference between the two groups.

Conclusion

When PCI is used for STEMI, only DCB therapy is safe and effective, and has shown good clinical effects during a one-year follow-up period.

Stone GW, Witzenbichiler B, Guagliumiu G, Peruga JZ, Brodie BR, Dudek D, etc. In acute myocardial infarction (HORIZONS-AMI) Heparinplus glycoprotein IIb / herIIIa inhibitor and bivalirudin monotherapy, inhibitor and bivalirudin monotherapy, and paclitaxel-eluting stent and bar mental stent comparison: the final 3 years from A multicenter, randomized controlled trial. Lancet. 2011;377:2193-204.

Luca GD, Suryapranata H, Stone GW, Antoniucci D, Biondi-Zoccai G, Kastrati A, etc. Coronary stenting and balloon angioplasty for acute myocardial infarction: Meta regression analysis of a randomized trial[J]. Int J glycol. 2008; 126(1):37-44. https://doi.org/10.1016/j.ijcard.2007.03.112.

Wang HR, Zhang CP, Wang Z, Zhang M, Zhao L. Clinical application and research status of drug-coated balloon in percutaneous coronary intervention. Chinese Medical Journal. 2019;10:1583-6.

Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, etc. 2018 ESC / EACTS Myocardial Revascularization Guidelines. Eur Heart J. 2019;40(2):87–165. https://doi.org/10.1093/eurheartj/ehy394 .

Holmvang L, Kelbk H, Kaltto A, Thuesen L, Lassen JF, Clemmensen P, etc. Long-term results of ST-segmengt elevated myocardial infarction after the patient’s drug-eluting and bar psychological stent implantation: 5-year follow-up from random intermittent injection of CA TI (drug elution and distal protection for acute myocardial infarction) to titanium aluminum alloy. JACC Cardiovascular Intervention 2013;6960:548–53.

Indermuehle A, Bahl R, Lansky AJ, Froehlich GM, Knapp G, Timmis A, etc. Drug-eluting balloon angioplasty for stent restenosis: a systematic view and a meta-analysis of randomized controlled trials. heart. 2013;99(5):327-33. https://doi.org/10.1136/heartjnl-2012-302945 .

Posa A, Nyolczas N, Hemetsberger R, Pavo N, Penethazy O, Petrasi Z, etc. Optimizing the safety and effectiveness of drug-eluting balloons: Evaluation of the second-generation Paclitaxel-eluting porcine coronary DIOR balloon. Catheter cardiovascular interventional therapy. 2010;76(3):395-403. https://doi.org/10.1002/ccd.22468.

Finn AV, Nakazawa KG, Joner M, Kolodgie FD, Mont EK, Gold HK, etc. Vascular response to drug-eluting stents: the importance of delayed healing. Arterial Thromboembolism Vascular Biology. 2007;27(7):1500-10. https://doi.org/10.1161/ATVBAHA.107.144220 .

Yazdani SK, Pacheco E, Nakanookinetic M, Kolodgie FD, Mont EK, Gold HK, etc. The downstream of the blood vessel in the porcine femoral artery model and the pharmacokinetic response of the low-dose drug-coated balloon to the drug treatment. Catheter cardiovascular interventional therapy. 2014;83(1):132–40. https://doi.org/10.1002/ccd.24995.

10.

Windecker S, Kolh P. 2014 ESC/EATS Myocardial Revascularization Guidelines: The European Society of Cardiology (ESC) and the European Association of Cardiothoracic Surgery (EACT S)’s Myocardial Revascularization Task Force in the European Association for Percutaneous Cardiovascular Intervention (EAPC) I). Eur Heart J. 2014;35(37):2541-619. https://doi.org/10.1093/eurheartj/ehu278.

11.

Belkacemi A, Agostoni P, Nathoe HM, Voskuil M, Shao C, Belle EV, etc. Preliminary results of DEB-AMI (Acute ST-segment drug-eluting balloon-segment level elevation myocardial infarction) test: In the case of initial percutaneous coronary intervention and 6-month angiography, the drug-eluting balloon Multi-center random comparison of purulent bare metal stents and drug-eluting stents, intravascular function and clinical results. J Am Coll Cardiol. 2012;59(25):2327-37. https://doi.org/10.1016/j.jacc.2012.02.027 .

12.

Chinese Society of Cardiovascular Diseases, Chinese Medical Association, "Chinese Journal of Cardiovascular Diseases" Editorial Board. Guidelines for the diagnosis and treatment of acute ST-segment elevation myocardial infarction. Chinese Journal of Cardiovascular Disease 2015;43:380–93.

13.

Cremers B, TonerJ L, Schwartz LB, Oepen RO, Speck U, Kaufels N, etc. Inhibition of neointimal hyperplasia by new-type zotalimus-coated balloon catheter. Clinical Res Cardiol. 2012;101(6):469-76. https://doi.org/10.1007/s00392-012-0415-7.

14.

Wohrle J, Zadura M, Mobius-WinkIer S, Leschke M, Opitz C, Ahmed W, etc. Subsequent global registration study: clinical results "subsequent to a large-scale, prospective registration study of paclitaxel-coated balloon angioplasty". J Am Coll Cardjol. 2012;60(18):1733-8. https://doi.org/10.1016/j.jacc.2012.07.040.

15.

López Mínguez JR, Nogales Asensio JM, Doncel Vecino LJ, Sandoval J, Romany S, Romero PM, etc. Prospective randomized study of paclitaxel-coated balloon catheter in the treatment of coronary artery bifurcation lesions (BABILON trial): 24-month clinical and angiographic results. Euro exchange rate. 2014;10(1):50-7. https://doi.org/10.4244/EIJV10I1A10.

16.

Higuma T, Soeda T, Abe N, Yamada M, Yokoyama H, Shibutani S, etc. The study of the combination of optical coherence tomography and intravascular ultrasound on plaque rupture, plaque erosion and calcified nodules in patients with ST-segment elevation myocardial infarction: the incidence, morphological characteristics and outcome after percutaneous coronary intervention. JACC Cardiovascular Intervention 2015;8(9):1166-76. https://doi.org/10.1016/j.jcin.2015.02.026.

17.

Wang Shan, Li DB. Research progress on the role of drug-coated balloons in acute ST-segment elevation myocardial infarction. Chinese Journal of Evidence-Based Medicine. 2018;10:1434-5.

18.

Jeger RV, Eccleshall S, Wan Ahmad WA, Ge JB, Poerner TC, Shin ES, etc. Drug-coated balloons for coronary artery disease: the third report of the International DCB Consensus Group[J]. JACC Cardiovascular Intervention 2020; 13(12):1391-402. https://doi.org/10.1016/j.jcin.2020.02.043 .

19.

Yu X, Ji F, Xu F, Zhang Wande, Wang Xinxi, Lu D, etc. Using only paclitaxel-coated balloons to treat de novo large coronary artery disease: results from a research institution in China. Clinical Res Cardiol. 2019;108(3):234–43. https://doi.org/10.1007/s00392-018-1346-8 .

20.

Magalhaes MA, Minha S, Chen F, Torguson R, Omar AF, Loh JP, etc. The clinical manifestations of the third-generation stent and the results of in-stent restenosis of the coronary artery. Circ Cardiovascular Intervention 2014;7(6):768-76. https://doi.org/10.1161/CIRCINTERVENTIONS.114.001341.

21.

Paramasivam G, Devasia T, Ubaid S, Shetty A, Nayak K, Pai U, etc. In-stent restenosis of drug-eluting stents: clinical manifestations and results in the real world. Heart of Egypt J.2019;71(1):28. https://doi.org/10.1186/s43044-019-0025-z.

22.

Jeger RV, Farah A, Ohlow MA, Mangner N, Möbius-WinklerS, Weilenmann D, etc. Long-term efficacy and safety of drug-coated balloons compared with drug-eluting stents in small coronary artery disease (BASKET-SMAL L 2): Three-year follow-up of a randomized, non-inferiority trial. Lancet. 2020;396(10261):1504-10. https://doi.org/10.1016/S0140-6736(20)32173-5.

23.

Axel DI, Kunert W, Gggelmann C, Oberhoff M, Herdeg C, Küttner A, etc. Paclitaxel inhibits the proliferation and migration of arterial smooth muscle cells in vitro and in vivo through local drug delivery. cycle. 1997;96(2):636-45. https://doi.org/10.1161/01.CIR.96.2.636 .

24.

Pan YY, Zhang Feng. The application progress of drug-eluting balloons in stent restenosis after percutaneous coronary intervention. Chinese Journal of Clinical Medicine 2018;133:161-6.

25.

Fang CY, Fang HY, Chen CJ, Yang CH, Wu CJ, Li WC. Comparison of clinical outcomes after in-stent restenosis-related acute myocardial infarction with drug-eluting balloon and drug-eluting stent: a retrospective study. Peer J. 2018;(6):e4646.

26.

Wang Hongxun. Efficacy and safety evaluation of paclitaxel-coated balbon in the treatment of restenosis in drug-eluting stents. Inner Mongolia Medical University. 2018.

27.

Dorenkamp M, Boldt J, Leber AW, Sohns C, Roser M, Boldt LH, etc. Cost-effectiveness of paclitaxel-coated balloon angioplasty in patients with drug-eluting stent restenosis. Clinical Cardiolo. 2013;36(7):407-13. https://doi.org/10.1002/clc.22130.

Title: Study on the safety and effectiveness of drug-coated balloons in patients with acute myocardial infarction
Authors: Xiaojiao Hao
Damin Huang
Zhaoxia Wang
Jinchun Zhang
Hongqiang Liu
Yingmin Lu
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: ST-Segment Elevation Myocardial Infarction
Myocardial Infarction
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01525-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Study on the safety and effectiveness of drug-coated balloons in patients with acute myocardial infarction

Abstract

Background

Method

Result

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Result

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2021

Rare chondroblastoma of the 6th left rib, video-assisted thoracoscopy resected: one case report and literature review

Perioperative outcomes of coronary artery bypass graft surgery in Johannesburg, South Africa

Surgical treatment for anomalous origin of the right coronary artery from the pulmonary artery: a case report with five-year follow-up

Safety analysis of early oral feeding after esophagectomy in patients complicated with diabetes

Isolated ascending aorta dilatation is associated with increased risk of abdominal aortic aneurysm

5-year results of a newly implemented mechanical circulatory support program for terminal heart failure patients in a Swiss non-cardiac transplant university hospital