Issue 8/2020
Content (23 Articles)
Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade
Marina Natoli, Nair Bonito, James D. Robinson, Sadaf Ghaem-Maghami, Yumeng Mao
Correction to: Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade
Marina Natoli, Nair Bonito, James D. Robinson, Sadaf Ghaem-Maghami, Yumeng Mao
Knocking out matrix metalloproteinase 12 causes the accumulation of M2 macrophages in intestinal tumor microenvironment of mice
Mingming Yang, Xiaohan Zhang, Qing Liu, Ting Niu, Lingbi Jiang, Haobin Li, Jianbiao Kuang, Cuiling Qi, Qianqian Zhang, Xiaodong He, Lijing Wang, Jiangchao Li
The glucocorticoids prednisone and dexamethasone differentially modulate T cell function in response to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade
Isobel S. Okoye, Lai Xu, John Walker, Shokrollah Elahi
Expression of the immune checkpoint VISTA in breast cancer
Liju Zong, Shengwei Mo, Shuangni Yu, Yuncan Zhou, Ming Zhang, Jie Chen, Yang Xiang
Correction to: Expression of the immune checkpoint VISTA in breast cancer
Liju Zong, Shengwei Mo, Shuangni Yu, Yuncan Zhou, Ming Zhang, Jie Chen, Yang Xiang
Neuroendocrine tumours and their microenvironment
Lotte D. de Hosson, Tim J. Takkenkamp, Gursah Kats-Ugurlu, Grietje Bouma, Marian Bulthuis, Elisabeth G. E. de Vries, Martijn van Faassen, Ido P. Kema, Annemiek M. E. Walenkamp
Interleukin-33 pretreatment promotes metastatic growth of murine melanoma by reducing the cytotoxic capacity of CD8+ T cells and enhancing regulatory T cells
Andra Jevtovic, Jelena Pantic, Ivan Jovanovic, Marija Milovanovic, Ivan Stanojevic, Danilo Vojvodic, Nebojsa Arsenijevic, Miodrag L. Lukic, Gordana D. Radosavljevic
Combined blockade of TGf-β1 and GM-CSF improves chemotherapeutic effects for pancreatic cancer by modulating tumor microenvironment
Qiaofei Liu, Huanwen Wu, Yuan Li, Ronghua Zhang, Jorg Kleeff, Xiang Zhang, Ming Cui, Jingkai Liu, Tong Li, Junyi Gao, Boju Pan, Wenming Wu, Weibin Wang, Li Zhou, Junchao Guo, Menghua Dai, Taiping Zhang, Quan Liao, Zhaohui Lu, Yupei Zhao
Characterization of CD103+ CD8+ tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade
Lu Han, Quan-Li Gao, Xiu-Man Zhou, Chao Shi, Guan-Yu Chen, Yong-Ping Song, Yong-Jie Yao, Yu-Miao Zhao, Xue-Yan Wen, Shi-Lei Liu, Yuan-Ming Qi, Yan-Feng Gao
PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade
Marcel P. Trefny, Monika Kaiser, Michal A. Stanczak, Petra Herzig, Spasenija Savic, Mark Wiese, Didier Lardinois, Heinz Läubli, Franziska Uhlenbrock, Alfred Zippelius
18F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer
Kyle G. Mitchell, Behrang Amini, Yunfei Wang, Brett W. Carter, Myrna C. B. Godoy, Edwin R. Parra, Carmen Behrens, Pamela Villalobos, Alexandre Reuben, J. Jack Lee, Annikka Weissferdt, Cesar A. Moran, Junya Fujimoto, Boris Sepesi, Garrett L. Walsh, Ara A. Vaporciyan, Wayne L. Hofstetter, William N. William Jr., Don L. Gibbons, Jing Wang, Patrick Hwu, Stephen G. Swisher, David Piwnica-Worms, Humam Kadara, Ignacio I. Wistuba, John V. Heymach, Weiyi Peng, Tina Cascone
Characterization of an HLA-restricted and human cytomegalovirus-specific antibody repertoire with therapeutic potential
Moritz Bewarder, Gerhard Held, Lorenz Thurner, Stephan Stilgenbauer, Sigrun Smola, Klaus-Dieter Preuss, Gabi Carbon, Birgit Bette, Konstantinos Christofyllakis, Joerg Thomas Bittenbring, Arne Felbel, Alexander Hasse, Niels Murawski, Dominic Kaddu-Mulindwa, Frank Neumann
Prognostic impact of stromal and intratumoral CD3, CD8 and FOXP3 in adjuvantly treated breast cancer: do they add information over stromal tumor-infiltrating lymphocyte density?
Triantafyllia Koletsa, Vassiliki Kotoula, Georgia-Angeliki Koliou, Kyriaki Manousou, Sofia Chrisafi, Flora Zagouri, Maria Sotiropoulou, George Pentheroudakis, Alexandra Papoudou-Bai, Christos Christodoulou, Grigorios Xepapadakis, George Zografos, Kalliopi Petraki, Elissavet Pazarli, Angelos Koutras, Helen P. Kourea, Dimitrios Bafaloukos, Kyriakos Chatzopoulos, Alexandros Iliadis, Christos Markopoulos, Vasileios Venizelos, Niki Arnogiannaki, Konstantine T. Kalogeras, Ioannis Kostopoulos, Helen Gogas, George Fountzilas
Tumor-infiltrating CD39+CD8+ T cells determine poor prognosis and immune evasion in clear cell renal cell carcinoma patients
Yu Qi, Yu Xia, Zhiyuan Lin, Yang Qu, Yangyang Qi, Yifan Chen, Quan Zhou, Han Zeng, Jiajun Wang, Yuan Chang, Qi Bai, Yiwei Wang, Yu Zhu, Le Xu, Lingli Chen, Yunyi Kong, Weijuan Zhang, Bo Dai, Li Liu, Jianming Guo, Jiejie Xu
Characterising the prognostic potential of HLA-DR during colorectal cancer development
Margaret R. Dunne, James J. Phelan, Adriana J. Michielsen, Aoife A. Maguire, Cara Dunne, Petra Martin, Sinead Noonan, Miriam Tosetto, Robert Geraghty, David Fennelly, Kieran Sheahan, Elizabeth J. Ryan, Jacintha O’Sullivan
Energy metabolism and cell motility defect in NK-cells from patients with hepatocellular carcinoma
Alessandra Zecca, Valeria Barili, Diana Canetti, Valeria Regina, Andrea Olivani, Chiara Carone, Valentina Capizzuto, Barbara Zerbato, Tommaso Trenti, Raffaele Dalla Valle, Carlo Ferrari, Elisabetta Cariani, Gabriele Missale
Outcomes with immune checkpoint inhibitors for relapsed small-cell lung cancer in a Swiss cohort
Sabine Schmid, Laetitia A. Mauti, Alex Friedlaender, Veronika Blum, Sacha I. Rothschild, Hasna Bouchaab, Patrizia Frösch, Christian Britschgi, David König, Luciano Wannesson, Wolf-Dieter Janthur, Sämi Schär, Izadora Demmer, Alfredo Addeo, Wolfram Jochum, Martin Früh
Epstein–Barr virus (EBV) and polyomaviruses are detectable in oropharyngeal cancer and EBV may have prognostic impact
Timo Carpén, Stina Syrjänen, Lauri Jouhi, Reija Randen-Brady, Caj Haglund, Antti Mäkitie, Petri S. Mattila, Jaana Hagström
Prevalence of PD-L1 expression is associated with EMAST, density of peritumoral T-cells and recurrence-free survival in operable non-metastatic colorectal cancer
Martin M. Watson, Dordi Lea, Einar Gudlaugsson, Ivar Skaland, Hanne R. Hagland, Kjetil Søreide
NK1R antagonist decreases inflammation and metastasis of breast carcinoma cells metastasized to liver but not to brain; phenotype-dependent therapeutic and toxic consequences
Esra Nizam, Sadi Köksoy, Nuray Erin
A phase I study of multi-HLA-binding peptides derived from heat shock protein 70/glypican-3 and a novel combination adjuvant of hLAG-3Ig and Poly-ICLC for patients with metastatic gastrointestinal cancers: YNP01 trial
Masao Nakajima, Shoichi Hazama, Koji Tamada, Keiko Udaka, Yasunobu Kouki, Toshinari Uematsu, Hideki Arima, Akira Saito, Shun Doi, Hiroto Matsui, Yoshitaro Shindo, Satoshi Matsukuma, Shinsuke Kanekiyo, Yukio Tokumitsu, Shinobu Tomochika, Michihisa Iida, Shin Yoshida, Yuki Nakagami, Nobuaki Suzuki, Shigeru Takeda, Shigeru Yamamoto, Shigefumi Yoshino, Tomio Ueno, Hiroaki Nagano
Tumor infiltrating lymphocytes as adjuvant treatment in stage III melanoma patients with only one invaded lymph node after complete resection: results from a multicentre, randomized clinical phase III trial
Amir Khammari, Jean-Michel Nguyen, Marie-Thérèse Leccia, Bernard Guillot, Soraya Saiagh, Marie-Christine Pandolfino, Anne-Chantal Knol, Gaëlle Quéreux, Anne Chiffolettau, Nathalie Labarrière, Brigitte Dréno