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Cancer Chemotherapy and Pharmacology

Issue 1/2008

Content (20 Articles)

Original Article

A randomized trial of anemia correction with two different hemoglobin targets in the first-line chemotherapy of advanced gastric cancer

Se Hoon Park, Eunmi Nam, Soo-Mee Bang, Eun Kyung Cho, Dong Bok Shin, Jae Hoon Lee

Original Article

Sequential vinorelbine–capecitabine followed by docetaxel in advanced breast cancer: long-term results of a pilot phase II trial

Marwan Ghosn, Joseph Kattan, Fadi Farhat, Fariha Younes, Fadi Nasr, Walid Moukadem, Jamal Gasmi, Georges Chahine

Original Article

Preclinical studies of treosulfan demonstrate potent activity in Ewing’s sarcoma

Sebastian Werner, Arnulfo Mendoza, Ralf A. Hilger, Miriam Erlacher, Wilfried Reichardt, Andrej Lissat, Claudia Konanz, Marcus Uhl, Charlotte M. Niemeyer, Chand Khanna, Udo Kontny

Original Article

Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis

Richard M. Logan, Rachel J. Gibson, Joanne M. Bowen, Andrea M. Stringer, Stephen T. Sonis, Dorothy M. K. Keefe

Original Article

Phase I study of vinorelbine and irinotecan in previously untreated patients with advanced non-small cell lung cancer

Nanae Tomonaga, Yoichi Nakamura, Hiroshi Soda, Seiji Nagashima, Hirofumi Nakano, Akitoshi Kinoshita, Masaaki Fukuda, Minoru Fukuda, Hiroshi Takatani, Yoshifumi Soejima, Mikio Oka, Shigeru Kohno

Original Article

In vitro evaluation of the effects of gefitinib on the modulation of cytotoxic activity of selected anticancer agents in a panel of human ovarian cancer cell lines

Judith A. Smith, Anjali Gaikwad, Jiang Yu, Judith K. Wolf, Jubilee Brown, Lois M. Ramondetta, Clinton F. Stewart

Original Article

A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein–Barr virus DNA as a biomarker of efficacy

Brigette Ma, Edwin P. Hui, Ann King, K. F. To, Frankie Mo, Sing F. Leung, Michael Kam, Y. M. Dennis Lo, Benny Zee, Tony Mok, Anil Ahuja, Anthony T. C. Chan

Original Article

Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia

Peter D. Cole, Richard A. Drachtman, Margaret Masterson, Angela K. Smith, John Glod, John A. Zebala, Stacey Lisi, Drew-Anne Drapala, Barton A. Kamen

Original Article

A phase II study of capecitabine and cisplatin (XP) as first-line chemotherapy in patients with advanced esophageal squamous cell carcinoma

Jeeyun Lee, Young-Hyuck Im, Eun Yoon Cho, Yong Sang Hong, Hyo Rak Lee, Hyo Song Kim, Mi-Jin Kim, Kwhanmien Kim, Won Ki Kang, Keunchil Park, Young Mog Shim

Original Article

Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity

Vincenzo Guarcello, Carmelo Blanquicett, Fardos N. M. Naguib, Mahmoud H. el Kouni

Original Article

Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety

Feng Guo, Stephen P. Letrent, Pamela N. Munster, Carolyn D. Britten, Karen Gelmon, Anthony W. Tolcher, Amarnath Sharma

Original Article

Mechanistic study of potentiation of chemotherapy by a haloenol lactone derivative in vitro

Wei Wang, Cindy Q. Xia, Ning Liu, Liang-Shang Gan, Jiang Zheng

Original Article

Pharmacodynamic model for chemotherapy-induced anemia in rats

Sukyung Woo, Wojciech Krzyzanski, William J. Jusko

Original Article

Semimechanistic pharmacokinetic/pharmacodynamic model for hepatoprotective effect of dexamethasone on transient transaminitis after trabectedin (ET-743) treatment

Gerald J. Fetterly, Joel S. Owen, Kim Stuyckens, Julie A. Passarell, Peter Zannikos, Arturo Soto-Matos, Miguel Angel Izquierdo, Juan Jose Perez-Ruixo

Original Article

Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer

Howard H. Bailey, Steven Attia, Richard R. Love, Terri Fass, Rick Chappell, Kendra Tutsch, Linda Harris, Alcee Jumonville, Richard Hansen, Gary R. Shapiro, James A. Stewart

Original Article

Efficacy and safety of trastuzumab plus capecitabine in heavily pretreated patients with HER2-positive metastatic breast cancer

Tomo Osako, Yoshinori Ito, Shunji Takahashi, Nahomi Tokudome, Takuji Iwase, Kiyohiko Hatake

Original Article

Bisphosphonates induce apoptosis in CLL cells independently of MDR phenotype

Karina Lani Silva, Deborah Vidal Vasconcellos, Eric Delfraro de Paula Castro, Flavia da Cunha Vasconcelos, Ricardo Bigni, Raquel Ciuvalschi Maia

Clinical Trial Report

Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative, for the treatment of patients with non-small cell lung cancer

J. Horti, E. Juhasz, Z. Monostori, K. Maeda, S. Eckhardt, I. Bodrogi

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
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