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Acta Neuropathologica

Issue 3/2018

Content (12 Articles)

Open Access Review

Functional morphology of the blood–brain barrier in health and disease

Stefan Liebner, Rick M. Dijkhuizen, Yvonne Reiss, Karl H. Plate, Dritan Agalliu, Gabriela Constantin

Open Access Review

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

Jean-François Ghersi-Egea, Nathalie Strazielle, Martin Catala, Violeta Silva-Vargas, Fiona Doetsch, Britta Engelhardt

Open Access Review

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS

Roy O. Weller, Matthew M. Sharp, Myron Christodoulides, Roxana O. Carare, Kjeld Møllgård

Open Access Review

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

N. Joan Abbott, Michelle E. Pizzo, Jane E. Preston, Damir Janigro, Robert G. Thorne

Open Access Original Paper

Neuronal complex I deficiency occurs throughout the Parkinson’s disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage

Irene H. Flønes, Erika Fernandez-Vizarra, Maria Lykouri, Brage Brakedal, Geir Olve Skeie, Hrvoje Miletic, Peer K. Lilleng, Guido Alves, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Christian Dölle, Massimo Zeviani, Charalampos Tzoulis

Open Access Original Paper

A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism

Bart Swinnen, Andre Bento-Abreu, Tania F. Gendron, Steven Boeynaems, Elke Bogaert, Rik Nuyts, Mieke Timmers, Wendy Scheveneels, Nicole Hersmus, Jiou Wang, Sarah Mizielinska, Adrian M. Isaacs, Leonard Petrucelli, Robin Lemmens, Philip Van Damme, Ludo Van Den Bosch, Wim Robberecht

Open Access Original Paper

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD

Thomas G. Moens, Sarah Mizielinska, Teresa Niccoli, Jamie S. Mitchell, Annora Thoeng, Charlotte E. Ridler, Sebastian Grönke, Jacqueline Esser, Amanda Heslegrave, Henrik Zetterberg, Linda Partridge, Adrian M. Isaacs

Original Paper

Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis

Shahram Saberi, Jennifer E. Stauffer, Jie Jiang, Sandra Diaz Garcia, Amy E. Taylor, Derek Schulte, Takuya Ohkubo, Cheyenne L. Schloffman, Marcus Maldonado, Michael Baughn, Maria J. Rodriguez, Don Pizzo, Don Cleveland, John Ravits

Open Access Commentary

RNA versus protein toxicity in C9orf72 ALS/FTLD

Thomas Arzberger, Martin H. Schludi, Carina Lehmer, Bettina Schmid, Dieter Edbauer

Correspondence

cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC)

David N. Louis, Pieter Wesseling, Werner Paulus, Caterina Giannini, Tracy T. Batchelor, J. Gregory Cairncross, David Capper, Dominique Figarella-Branger, M. Beatriz Lopes, Wolfgang Wick, Martin van den Bent

Correspondence

Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway

Melike Pekmezci, Meredith Stevers, Joanna J. Phillips, Jessica Van Ziffle, Boris C. Bastian, Nadejda M. Tsankova, Bette K. Kleinschmidt-DeMasters, Marc K. Rosenblum, Tarik Tihan, Arie Perry, David A. Solomon