Issue 2/2014
Content (14 Articles)
Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development
Gunnar Hargus, Marc Ehrlich, Anna-Lena Hallmann, Tanja Kuhlmann
Systems biology of primary CNS lymphoma: from genetic aberrations to modeling in mice
Martina Deckert, Manuel Montesinos-Rongen, Anna Brunn, Reiner Siebert
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group
Nicholas G. Gottardo, Jordan R. Hansford, Jacqueline P. McGlade, Frank Alvaro, David M. Ashley, Simon Bailey, David L. Baker, Franck Bourdeaut, Yoon-Jae Cho, Moira Clay, Steven C. Clifford, Richard J. Cohn, Catherine H. Cole, Peter B. Dallas, Peter Downie, François Doz, David W. Ellison, Raelene Endersby, Paul G. Fisher, Timothy Hassall, John A. Heath, Hilary L. Hii, David T. W. Jones, Reimar Junckerstorff, Stewart Kellie, Marcel Kool, Rishi S. Kotecha, Peter Lichter, Stephen J. Laughton, Sharon Lee, Geoff McCowage, Paul A. Northcott, James M. Olson, Roger J. Packer, Stefan M. Pfister, Torsten Pietsch, Barry Pizer, Scott L. Pomeroy, Marc Remke, Giles W. Robinson, Stefan Rutkowski, Tobias Schoep, Anang A. Shelat, Clinton F. Stewart, Michael Sullivan, Michael D. Taylor, Brandon Wainwright, Thomas Walwyn, William A. Weiss, Dan Williamson, Amar Gajjar
Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes
Daniel Stieber, Anna Golebiewska, Lisa Evers, Elizabeth Lenkiewicz, Nicolaas H. C. Brons, Nathalie Nicot, Anaïs Oudin, Sébastien Bougnaud, Frank Hertel, Rolf Bjerkvig, Laurent Vallar, Michael T. Barrett, Simone P. Niclou
Autophagy and oxidative stress in gliomas with IDH1 mutations
Misty R. Gilbert, Yinxing Liu, Janna Neltner, Hong Pu, Andrew Morris, Manjula Sunkara, Thomas Pittman, Natasha Kyprianou, Craig Horbinski
Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease
David Hilton, Madeleine Stephens, Leanne Kirk, Philip Edwards, Ross Potter, John Zajicek, Ellie Broughton, Hannah Hagan, Camille Carroll
Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection
Xiaochuan Wang, Julie Blanchard, Inge Grundke-Iqbal, Jerzy Wegiel, Han-Xiang Deng, Teepu Siddique, Khalid Iqbal
Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model
Manuela Polydoro, Volodymyr I. Dzhala, Amy M. Pooler, Samantha B. Nicholls, A. Patrick McKinney, Laura Sanchez, Rose Pitstick, George A. Carlson, Kevin J. Staley, Tara L. Spires-Jones, Bradley T. Hyman
Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration
Naomi Kouri, Yari Carlomagno, Matthew Baker, Amanda M. Liesinger, Richard J. Caselli, Zbigniew K. Wszolek, Leonard Petrucelli, Bradley F. Boeve, Joseph E. Parisi, Keith A. Josephs, Ryan J. Uitti, Owen A. Ross, Neill R. Graff-Radford, Michael A. DeTure, Dennis W. Dickson, Rosa Rademakers
The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons
Mariangela Iovino, Ulrich Pfisterer, Janice L. Holton, Tammaryn Lashley, Robert J. Swingler, Laura Calo, Rebecca Treacy, Tamas Revesz, Malin Parmar, Michel Goedert, Miratul M. K. Muqit, Maria Grazia Spillantini
Neuropathological characterization of two siblings carrying the MAPT S305S mutation demonstrates features resembling argyrophilic grain disease
Annica Rönnbäck, Inger Nennesmo, Hannu Tuominen, Fiona Grueninger, Matti Viitanen, Caroline Graff
Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice
Florence Clavaguera, Jürgen Hench, Isabelle Lavenir, Gabriel Schweighauser, Stephan Frank, Michel Goedert, Markus Tolnay
3R and 4R tau isoforms in paired helical filaments in Alzheimer’s disease
Masato Hasegawa, Sayuri Watanabe, Hiromi Kondo, Haruhiko Akiyama, David M. A. Mann, Yuko Saito, Shigeo Murayama
TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours
Janet C. Lindsey, Ed. C. Schwalbe, Sandeep Potluri, Simon Bailey, Daniel Williamson, Steven C. Clifford