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Published in: BMC Infectious Diseases 1/2018

Open Access 01-12-2018 | Case report

Spotted fever rickettsioses causing myocarditis and ARDS: a case from Sri Lanka

Authors: H. M. L. Y. Herath, J. M. H. D. Jayasundara, S. D. N. Senadhira, S. A. M. Kularatne, W. K. S. Kularatne

Published in: BMC Infectious Diseases | Issue 1/2018

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Abstract

Background

Spotted fever group of rickettsial infections are emerging in Sri Lanka. We describe a patient with rapidly progressing ARDS and myocarditis secondary to spotted fever caused by Rickettsia conorii. ARDS and myocarditis are rare complications of Rickettsia conorii infections and only a few cases are reported to date.

Case presentation

A 53 years old manual worker presented with fever for 5 days and a skin rash. He was in circulatory failure on admission and developed severe hypoxaemia with gross changes in chest radiograph by next day requiring assisted ventilation. He had myocarditis causing left ventricular failure and acute respiratory distress syndrome. He was confirmed to have spotted fever rickettsial infection with rising titre of indirect immunofluorescence antibodies to Ricketssia conorii and made a complete recovery with appropriate antibiotic therapy and supportive care.

Conclusion

Rickettsial infections can present with diverse manifestations. Even the patients with severe organ involvements such as myocarditis and ARDS can be completely cured if timely identified and treated.
Literature
1.
go back to reference Kularatne SA, Edirisinghe JS, Gawarammana IB, Urakami H, Chenchittikul M, Kioho I. Emerging rickettsial infections in Sri Lanka: the pattern in the hilly Central Province. Tropical Med Int Health. 2003;8:803–11.CrossRef Kularatne SA, Edirisinghe JS, Gawarammana IB, Urakami H, Chenchittikul M, Kioho I. Emerging rickettsial infections in Sri Lanka: the pattern in the hilly Central Province. Tropical Med Int Health. 2003;8:803–11.CrossRef
2.
go back to reference Liyanapathirana VC, Thevanesam V. Seroepidemiology of rickettsioses in Sri Lanka: a patient based study. BMC Infect Dis. 2011;11:328.CrossRef Liyanapathirana VC, Thevanesam V. Seroepidemiology of rickettsioses in Sri Lanka: a patient based study. BMC Infect Dis. 2011;11:328.CrossRef
3.
go back to reference Kularatne SAM, Weerakoon KGAD, Rajapakse RPVJ, Madagedara SC, Nanayakkara D, Premaratna R. A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. Int J Infect Dis. 2012;16(7):514–7.CrossRef Kularatne SAM, Weerakoon KGAD, Rajapakse RPVJ, Madagedara SC, Nanayakkara D, Premaratna R. A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. Int J Infect Dis. 2012;16(7):514–7.CrossRef
5.
go back to reference Herrador Z, Fernandez-Martinez A, Gomez-Barroso D, León I, Vieira C, Muro A, et al. Mediterranean spotted fever in Spain, 1997-2014: epidemiological situation based on hospitalization records. PLoS One. 2017;12(3):e0174745.CrossRef Herrador Z, Fernandez-Martinez A, Gomez-Barroso D, León I, Vieira C, Muro A, et al. Mediterranean spotted fever in Spain, 1997-2014: epidemiological situation based on hospitalization records. PLoS One. 2017;12(3):e0174745.CrossRef
6.
go back to reference Cascio A, Pernice LM, Barberi G, Delfino D, Biondo C, Beninati C, Mancuso G, Rodriguez-Morales AJ, Iaria C. Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review. Eur Rev Med Pharmacol Sci. 2012;16:1324–37.PubMed Cascio A, Pernice LM, Barberi G, Delfino D, Biondo C, Beninati C, Mancuso G, Rodriguez-Morales AJ, Iaria C. Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review. Eur Rev Med Pharmacol Sci. 2012;16:1324–37.PubMed
7.
go back to reference Cascio A, Giordano S, Dones P, Venezia S, Iaria C, Ziino O. Haemophagocytic syndrome and rickettsial diseases. J Med Microbiol. 2011;60:537–42.CrossRef Cascio A, Giordano S, Dones P, Venezia S, Iaria C, Ziino O. Haemophagocytic syndrome and rickettsial diseases. J Med Microbiol. 2011;60:537–42.CrossRef
8.
go back to reference Revilla-Martí P, Cecilio-Irazola Á, Gayán-Ordás J, Sanjoaquín-Conde I, Linares-Vicente JA, Oteo JA. Acute Myopericarditis Associated with Tickborne Rickettsia sibirica mongolitimonae. Emerg Infect Dis. 2017;23(12):2091–3.CrossRef Revilla-Martí P, Cecilio-Irazola Á, Gayán-Ordás J, Sanjoaquín-Conde I, Linares-Vicente JA, Oteo JA. Acute Myopericarditis Associated with Tickborne Rickettsia sibirica mongolitimonae. Emerg Infect Dis. 2017;23(12):2091–3.CrossRef
11.
go back to reference Kularatne SAM, Pathirage MMK, Kumarasiri PVR, Gunasena S, Mahindawanse SI. Cardiac complications of a dengue fever outbreak in Sri Lanka. Trans R Soc Trop Med Hyg. 2007;101:804–8.CrossRef Kularatne SAM, Pathirage MMK, Kumarasiri PVR, Gunasena S, Mahindawanse SI. Cardiac complications of a dengue fever outbreak in Sri Lanka. Trans R Soc Trop Med Hyg. 2007;101:804–8.CrossRef
12.
go back to reference Bellini C, Monti M, Potin M, Ave AD, Bille J, Greub G. Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. BMC Infect Dis. 2005;5:90.CrossRef Bellini C, Monti M, Potin M, Ave AD, Bille J, Greub G. Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. BMC Infect Dis. 2005;5:90.CrossRef
13.
go back to reference Schultz JC, Hilliard AA, Cooper LT, Rihal CS. Diagnosis and treatment of viral myocarditis. Mayo Clin Proc. 2009;84(11):1001–9.CrossRef Schultz JC, Hilliard AA, Cooper LT, Rihal CS. Diagnosis and treatment of viral myocarditis. Mayo Clin Proc. 2009;84(11):1001–9.CrossRef
14.
go back to reference Caforio AL, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on myocardial and pericardial diseases. Eur Heart J. 2013;34:2636–48.CrossRef Caforio AL, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on myocardial and pericardial diseases. Eur Heart J. 2013;34:2636–48.CrossRef
15.
go back to reference Biggs HM, Behravesh CB, Bradley KK, et al. Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, Ehrlichioses, and Anaplasmosis — United States. MMWR Recomm Rep 2016;65(No RR-2):1–44. Biggs HM, Behravesh CB, Bradley KK, et al. Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, Ehrlichioses, and Anaplasmosis — United States. MMWR Recomm Rep 2016;65(No RR-2):1–44.
16.
go back to reference Holman RC, Paddock CD, Curns AT, Krebs JW, McQuiston JH, Childs JE. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence for superiority of tetracyclines for therapy. J Infect Dis. 2001;184:1437–44.CrossRef Holman RC, Paddock CD, Curns AT, Krebs JW, McQuiston JH, Childs JE. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence for superiority of tetracyclines for therapy. J Infect Dis. 2001;184:1437–44.CrossRef
Metadata
Title
Spotted fever rickettsioses causing myocarditis and ARDS: a case from Sri Lanka
Authors
H. M. L. Y. Herath
J. M. H. D. Jayasundara
S. D. N. Senadhira
S. A. M. Kularatne
W. K. S. Kularatne
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2018
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-018-3631-6

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