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Dermatology and Therapy
Published in: Dermatology and Therapy 1/2021

Open Access 01-02-2021 | Spironolactone | Review

New Acne Therapies and Updates on Use of Spironolactone and Isotretinoin: A Narrative Review

Authors: Jane J. Han, Adam Faletsky, John S. Barbieri, Arash Mostaghimi

Published in: Dermatology and Therapy | Issue 1/2021

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Abstract

Acne vulgaris is a chronic inflammatory skin disease with a multifactorial pathogenesis. Although a variety of acne treatments are available, limitations of current therapies include tolerability, antimicrobial resistance, and costs and patient burden associated with monitoring. This narrative review focuses on emerging treatments and updates on the management of acne. Clascoterone, sarecycline, trifarotene, and novel lotion formulations of tretinoin and tazarotene have been evaluated in clinical trials and provide new options for treatment. Emerging data on the safety and efficacy of spironolactone and isotretinoin challenge current conventions and suggest a need to reconsider drug monitoring guidelines and risk prevention systems. Additional head-to-head data are needed to confirm these novel treatments’ utility in treating acne.
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Metadata
Title
New Acne Therapies and Updates on Use of Spironolactone and Isotretinoin: A Narrative Review
Authors
Jane J. Han
Adam Faletsky
John S. Barbieri
Arash Mostaghimi
Publication date
01-02-2021
Publisher
Springer Healthcare
Published in
Dermatology and Therapy / Issue 1/2021
Print ISSN: 2193-8210
Electronic ISSN: 2190-9172
DOI
https://doi.org/10.1007/s13555-020-00481-w

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