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Published in: Journal of Medical Case Reports 1/2023

Open Access 01-12-2023 | Spinal Cord Stimulation | Case report

Spinal cord stimulator explant caused by post-incisional cellulitis secondary to Varicella Zoster Virus (shingles) infection: a case report

Authors: Vahid Mohabbati, Mohammadkazem Papan

Published in: Journal of Medical Case Reports | Issue 1/2023

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Abstract

Introduction

Spinal Cord Stimulation (SCS) is a well-established therapy for refractory neuropathic pain, known for its safety and minimally-invasive nature. However, complications, including surgical site infections (SSIs), can arise post-implantation. SCS-related SSIs occur in 3.4% to 4.6% of cases within 90 days post-implant, often requiring device removal and impacting pain management and healthcare costs. The impulse generator, electrode implant site and lumbar/thoracic surgical site are commonly affected, with local skin flora and circulating organisms being the primary causes of infection.

Case presentation

An 80-year-old Lebanese male with chronic neuropathic lower back and bilateral leg pain, significantly impairing function, underwent prolonged hospitalizations for COVID-19 infection and acute-on-chronic pain with Urinary Tract Infection (UTI). Considering SCS as a therapeutic option, a successful trial led to permanent implantation, resulting in improved pain severity and functional capacity. However, three months later, the patient developed post-incisional cellulitis and wound dehiscence secondary to Varicella Zoster Virus (shingles) Infection directly over the Implantable Pulse Generator (IPG) incision line. Despite antibiotic treatment, the infection progressed, necessitating SCS system explantation.

Discussion

This represents the first reported case of VZV infection causing wound dehiscence and SCS explantation post-implantation. Contributing factors may include itching around the IPG site, facilitating deeper tissue inoculation. Laboratory and imaging tests may not reliably detect SSIs, and superficial infections may respond to antibiotics, while deep infections typically require implant removal. Early identification and intervention are vital to minimize complications.

Conclusion

This unique case emphasizes the need for heightened vigilance and monitoring in patients with viral infections near medical devices. A standardized approach to assessing and managing SCS-related infections is critical. Sharing such experiences contributes to improved understanding and treatment of these rare incidents.
Literature
2.
go back to reference Esquer Garrigos Z, Farid S, Bendel MA, Sohail MR. Spinal cord stimulator infection: approach to diagnosis, management, and prevention. Clin Infect Dis. 2020;70(12):2727–35.CrossRefPubMed Esquer Garrigos Z, Farid S, Bendel MA, Sohail MR. Spinal cord stimulator infection: approach to diagnosis, management, and prevention. Clin Infect Dis. 2020;70(12):2727–35.CrossRefPubMed
3.
go back to reference Fang M, Weng X, Chen L, Chen Y, Chi Y, Chen W, et al. Fulminant central nervous system varicella-zoster virus infection unexpectedly diagnosed by metagenomic next-generation sequencing in an HIV-infected patient: a case report. BMC Infect Dis. 2020;20(1):159.CrossRefPubMedPubMedCentral Fang M, Weng X, Chen L, Chen Y, Chi Y, Chen W, et al. Fulminant central nervous system varicella-zoster virus infection unexpectedly diagnosed by metagenomic next-generation sequencing in an HIV-infected patient: a case report. BMC Infect Dis. 2020;20(1):159.CrossRefPubMedPubMedCentral
5.
go back to reference Follett KA, Boortz-Marx RL, Drake JM, DuPen S, Schneider SJ, Turner MS, et al. Prevention and management of intrathecal drug delivery and spinal cord stimulation system infections. Anesthesiology. 2004;100(6):1582–94.CrossRefPubMed Follett KA, Boortz-Marx RL, Drake JM, DuPen S, Schneider SJ, Turner MS, et al. Prevention and management of intrathecal drug delivery and spinal cord stimulation system infections. Anesthesiology. 2004;100(6):1582–94.CrossRefPubMed
6.
go back to reference Falowski SM, Provenzano DA, Xia Y, Doth AH. Spinal cord stimulation infection rate and risk factors: results from a united states payer database. Neuromodulation. 2019;22(2):279–89.CrossRef Falowski SM, Provenzano DA, Xia Y, Doth AH. Spinal cord stimulation infection rate and risk factors: results from a united states payer database. Neuromodulation. 2019;22(2):279–89.CrossRef
7.
8.
go back to reference Deer TR, Provenzano DA, Hanes M, Pope JE, Thomson SJ, Russo MA, et al. The Neurostimulation Appropriateness Consensus Committee (NACC) recommendations for infection prevention and management. Neuromodulation. 2017;20(1):31–50.CrossRefPubMed Deer TR, Provenzano DA, Hanes M, Pope JE, Thomson SJ, Russo MA, et al. The Neurostimulation Appropriateness Consensus Committee (NACC) recommendations for infection prevention and management. Neuromodulation. 2017;20(1):31–50.CrossRefPubMed
9.
go back to reference Deer TR, Stewart CD. Complications of spinal cord stimulation: identification, treatment, and prevention. Pain Med. 2008;9(suppl 1):S93-101.CrossRef Deer TR, Stewart CD. Complications of spinal cord stimulation: identification, treatment, and prevention. Pain Med. 2008;9(suppl 1):S93-101.CrossRef
10.
go back to reference Han JL, Murphy KR, Hussaini SMQ, Yang S, Parente B, Xie J, et al. Explantation rates and healthcare resource utilization in spinal cord stimulation. Neuromodulation. 2017;20(4):331–9.CrossRefPubMedPubMedCentral Han JL, Murphy KR, Hussaini SMQ, Yang S, Parente B, Xie J, et al. Explantation rates and healthcare resource utilization in spinal cord stimulation. Neuromodulation. 2017;20(4):331–9.CrossRefPubMedPubMedCentral
11.
go back to reference Huang J, Wu Y, Wang M, Jiang J, Zhu Y, Kumar R, et al. The global disease burden of varicella-zoster virus infection from 1990 to 2019. J Med Virol. 2022;94(6):2736–46.CrossRefPubMed Huang J, Wu Y, Wang M, Jiang J, Zhu Y, Kumar R, et al. The global disease burden of varicella-zoster virus infection from 1990 to 2019. J Med Virol. 2022;94(6):2736–46.CrossRefPubMed
12.
go back to reference Walming S, Angenete E, Block M, Bock D, Gessler B, Haglind E. Retrospective review of risk factors for surgical wound dehiscence and incisional hernia. BMC Surg. 2017;17(1):19.CrossRefPubMedPubMedCentral Walming S, Angenete E, Block M, Bock D, Gessler B, Haglind E. Retrospective review of risk factors for surgical wound dehiscence and incisional hernia. BMC Surg. 2017;17(1):19.CrossRefPubMedPubMedCentral
13.
go back to reference Al-sadi A, Abdulgayoom M, Jawarneh I, Al-warqi A. Abducens nerve palsy as a complication of herpes zoster ophthalmicus: a case report. Cureus. 2022;14(3): e22920.PubMedPubMedCentral Al-sadi A, Abdulgayoom M, Jawarneh I, Al-warqi A. Abducens nerve palsy as a complication of herpes zoster ophthalmicus: a case report. Cureus. 2022;14(3): e22920.PubMedPubMedCentral
15.
go back to reference Katz J, Cooper EM, Walther RR, Sweeney EW, Dworkin RH. Acute pain in herpes zoster and its impact on health-related quality of life. Clin Infect Dis. 2004;39(3):342–8.CrossRefPubMed Katz J, Cooper EM, Walther RR, Sweeney EW, Dworkin RH. Acute pain in herpes zoster and its impact on health-related quality of life. Clin Infect Dis. 2004;39(3):342–8.CrossRefPubMed
16.
go back to reference Bendersky D, Yampolsky C. Is spinal cord stimulation safe? A review of its complications. World Neurosurg. 2014;82(6):1359–68.CrossRefPubMed Bendersky D, Yampolsky C. Is spinal cord stimulation safe? A review of its complications. World Neurosurg. 2014;82(6):1359–68.CrossRefPubMed
17.
go back to reference Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science (1979). 1999;284(5418):1318–22. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science (1979). 1999;284(5418):1318–22.
18.
go back to reference Shah S. Sixty-day pudendal nerve stimulation: a potential therapy for refractory pudendal neuralgia case report. Pain Med Case Rep. 2021;5(8):393–7.CrossRef Shah S. Sixty-day pudendal nerve stimulation: a potential therapy for refractory pudendal neuralgia case report. Pain Med Case Rep. 2021;5(8):393–7.CrossRef
19.
go back to reference Bendel MA, O’Brien T, Hoelzer BC, Deer TR, Pittelkow TP, Costandi S, et al. Spinal cord stimulator related infections: findings from a multicenter retrospective analysis of 2737 implants. Neuromodulation. 2017;20(6):553–7.CrossRefPubMed Bendel MA, O’Brien T, Hoelzer BC, Deer TR, Pittelkow TP, Costandi S, et al. Spinal cord stimulator related infections: findings from a multicenter retrospective analysis of 2737 implants. Neuromodulation. 2017;20(6):553–7.CrossRefPubMed
Metadata
Title
Spinal cord stimulator explant caused by post-incisional cellulitis secondary to Varicella Zoster Virus (shingles) infection: a case report
Authors
Vahid Mohabbati
Mohammadkazem Papan
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2023
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-023-04205-4

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