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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2023

Open Access 01-12-2023 | Case report

Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: a case report and review of the literature

Authors: Soichiro Toyodome, Tomoko Wakasa, Katsutoshi Hirose, Noriko Iwamoto, Seiya Suzuki, Naoto Nemoto, Satoru Toyosawa, Tetsuji Nagata

Published in: Journal of Medical Case Reports | Issue 1/2023

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Abstract

Background

Dentinogenic ghost cell tumor is a rare benign tumor that accounts for less than 3% of all cases and consists of the stellate reticulum, which is made up of enamel epithelioid and basaloid cells. Although DGCT is a benign tumor, the local infiltration of the odontogenic epithelium or recurrences have been reported, and its detailed pathology and treatments remain unclear.

Case presentation

This report describes the case of a 60-year-old Japanese male diagnosed with a maxillary dentinogenic ghost cell tumor. Images showed well-circumscribed, multilocular cystic lesions with a calcified substance in the interior. Marsupialization was performed along with biopsy to prevent the expansion of the lesion, and a partial maxillectomy was performed 2 years after the initial examination. Histopathological findings showed ameloblastomatous proliferation containing clusters of ghost cells and dentinoid materials, resulting in the diagnosis of dentinogenic ghost cell tumor. This article also reviews recently reported cases of dentinogenic ghost cell tumor.

Conclusion

It is important to perform marsupialization, proper resection, and postoperative follow-up because of possible recurrence.
Literature
1.
Sun G, Huang X, Hu Q, Yang X, Tang E. The diagnosis and treatment of dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg. 2009;38:1179–83.CrossRefPubMed
2.
Praetorius F, Ledesma-Montes C. Calcifying odontogenic tumor and dentinogenic ghost cell tumor. In: Barnes L, Evenson JW, Reinchart P, Sidranksy D, editors. World Health Organization classification of tumors. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. p. 313–4.
3.
Carlos R, Ledesma-Montes C. Dentinogenic ghost cell tumour. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. 4th ed. Lyon: IARC; 2017. p. 226–7.
4.
Speight P, Ledesma-Montes C, Wright JM. Calcifying odontogenic cyst. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. 4th ed. Lyon: IARC; 2017. p. 239–41.
5.
Prætorius F, Hjørting-Hansen E, Gorlin RJ, Vickers RA. Calcifying odontogenic cyst: range, variations and neoplastic potential. Acta Odontol Scand. 1981;39:227–40.CrossRefPubMed
6.
Juneja M, George J. Dentinogenic ghost cell tumor: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2009;107:e17–22.CrossRef
7.
Konstantakis D, Kosyfaki P, Ebhardt H, Schmelzeisen R, Voss PJ. Intraosseous dentinogenic ghost cell tumor: a clinical report and literature update. J Cranio-Maxillofac Surg. 2014;42:e305–11.CrossRef
8.
Zhang R, Yang Q, Qu J, Hong Y, Liu P, Li T. The BRAF p.V600E mutation is a common event in ameloblastomas but is absent in odontogenic keratocysts. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;129:229–35.CrossRefPubMed
9.
Ahire MS, Tupkari JV, Chettiankandy TJ, Thakur A, Agrawal RR. Odontogenic tumors: a 35-year retrospective study of 250 cases in an Indian (Maharashtra) teaching institute. Indian J Cancer. 2018;55:265.CrossRefPubMed
10.
Rosa ACG, Teixeira LN, Passador-Santos F, Furuse C, Montalli VÂM, de Araújo NS, et al. Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin. Clin Oral Invest. 2019;23:4335–43.CrossRef
11.
Urs AB, Jot K, Kumar M. Ghost cell characterization in calcifying odontogenic cysts and dentinogenic ghost cell tumors: an immunohistochemical study. J Oral Biosci. 2020;62:336–41.CrossRefPubMed
12.
Kennedy H, Visavadia B. Conservative management of mandibular dentinogenic ghost cell tumours: a minimally invasive approach. Br J Oral Maxillofac Surg. 2017;55:348–9.CrossRefPubMed
13.
14.
Bussari S, Thakur SM, Koshy AV, Shah AA. Dentinogenic ghost cell tumor—a case report and review of literature. J Oral Maxillofac Pathol. 2019;23:66–8.CrossRefPubMedPubMedCentral
15.
Ravi B, Kamath G, Srivathsa S, Babshet M, Dayanarayana U. Dentinogenic ghost cell tumor—a rare case report. J Stomatol Oral Maxillofac Surg. 2020;121:186–8.CrossRefPubMed
16.
Rai S, Prabhat M, Goel S, Bhalla K, Panjwani S, Misra D, et al. Dentinogenic ghost cell tumor—a neoplastic variety of calcifying odontogenic cyst: case presentation and review. N Am J Med Sci. 2015;7:19–23.CrossRefPubMedPubMedCentral
17.
Agrawal Y, Naidu GS, Makkad RS, Nagi R, Jain S, Gadewar DR, et al. Dentinogenic ghost cell tumor—a rare case report with review of literature. Quant Imaging Med Surg. 2017;7:598–604.CrossRefPubMedPubMedCentral
18.
19.
Korranne V, Merchant Y, Joshi S, Halli R. Dentinogenic ghost cell tumor: tumor in the garb of a cyst! J Oral Maxillofac Pathol. 2018;22:150.PubMedPubMedCentral
20.
Gupta S, Singh S, Anjum R, Sharma R. Dentinogenic ghost-cell tumor of the maxilla: a case report and review of literature. J Oral Maxillofac Pathol. 2019;23:478.CrossRefPubMedPubMedCentral
21.
22.
23.
Soares CD, Carlos R, de Lima Morais TM, de Almeida OP. Giant dentinogenic ghost cell tumor: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126:e215–9.CrossRefPubMed
24.
25.
Quinn M, Brace M, Bullock M, Hart RD, Taylor SM. Dentinogenic ghost cell tumor of the maxilla. Otolaryngol Head Neck Surg. 2008;139:604–5.CrossRefPubMed
26.
Biggs T, Hayes S, Harries P, Salib R. Maxillary dentinogenic ghost cell tumour. Ann R Coll Surg Engl. 2013;95:e9–11.CrossRef
27.
Park H-R, Min J-H, Huh K-H, Yi W-J, Heo M-S, Lee S-S, et al. Distant metastasis of intraosseous dentinogenic ghost cell tumour to the donor site of a bone graft. Dentomaxillofac Radiol. 2013;42:20120172.CrossRefPubMedPubMedCentral
28.
Etemad-Moghadam S, Baghaee F, Dadafarid Z, Alaeddini M. A 44-year analysis of ghost cell odontogenic tumour subtypes in an Iranian population. J Cranio-Maxillofac Surg. 2014;42:1154–9.CrossRef
29.
Gomes da Silva W, Ribeiro Bartholomeu dos Santos TC, Cabral MG, Azevedo RS, Pires FR. Clinicopathologic analysis and syndecan-1 and Ki-67 expression in calcifying cystic odontogenic tumors, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:626–33.CrossRefPubMed
30.
Nazaretian SP, Schenberg ME, Simpson I, Slootweg PJ. Ghost cell odontogenic carcinoma. Int J Oral Maxillofac Surg. 2007;36:455–8.CrossRefPubMed
31.
Arashiyama T, Kodama Y, Kobayashi T, Hoshina H, Takagi R, Hayashi T, et al. Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:e35-40.CrossRefPubMed
32.
Rappaport MJ, Showell DL, Edenfield WJ. Metastatic ghost cell odontogenic carcinoma: description of a case and search for actionable targets. Rare Tumors. 2015;7:96–7.CrossRef
33.
Li B-B, Gao Y. Ghost cell odontogenic carcinoma transformed from a dentinogenic ghost cell tumor of maxilla after multiple recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2009;107:691–5.CrossRef
34.
Candido GA, Viana KA, Watanabe S, Vencio EF. Peripheral dentinogenic ghost cell tumor: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2009;108:e86–90.CrossRef
Metadata
Title
Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: a case report and review of the literature
Authors
Soichiro Toyodome
Tomoko Wakasa
Katsutoshi Hirose
Noriko Iwamoto
Seiya Suzuki
Naoto Nemoto
Satoru Toyosawa
Tetsuji Nagata
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2023
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-023-03861-w

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