Skip to main content
Top
Published in: World Journal of Surgical Oncology 1/2008

Open Access 01-12-2008 | Case report

Spinal cord compression by a solitary metastasis from a low grade leydig cell tumour: a case report and review of the literature

Authors: Efthimios P Samoladas, Ashraf S Anbar, Jonathan D Lucas, Hlias Fotiadis, Byron E Chalidis

Published in: World Journal of Surgical Oncology | Issue 1/2008

Login to get access

Abstract

Background

Leydig tumour is rare and there are only three cases with metastatic disease reported.

Case presentation

A 52 year-old Caucasian male was admitted, on emergency basis to the Orthopaedic Department with six weeks history of increasing midthoracic back pain, change in gait, poor balance, subjective weakness and numbness of the lower trunk and legs. MRI scan showed change in the signal intensity of T4 and T5 vertebral body but their height were maintained. Urgent T4 and T5 corpectomies, decompression of the spinal cord and reconstruction of the vertebral bodies were performed followed by radiotherapy. Neurological status significantly improved with a mild residual numbness over the dorsum of the right foot. The histology of the excised tumour was identical to the primary. At 2 years follow-up visit the patient is neurologically stable and disease free without other organs metastases.

Conclusion

This is the first case in English literature, which shows that spinal metastases could occur even in the early stage of Leydig cell tumour, without other organs involvement. Aggressive surgical management of spinal metastases combined with post operative radiotherapy can give a better chance for long survivorship.
Appendix
Available only for authorised users
Literature
1.
go back to reference Black P: Spinal metastasis: Current status and recommended guidelines for management. Neurosurgery. 1979, 5: 726-746.CrossRefPubMed Black P: Spinal metastasis: Current status and recommended guidelines for management. Neurosurgery. 1979, 5: 726-746.CrossRefPubMed
2.
go back to reference Sawin PD, VanGilder JC: Spinal cord compression from metastatic Leydig's cell tumour of the testis: Case Report. Neurosurgery. 1996, 38: 407-411. 10.1097/00006123-199602000-00037.CrossRefPubMed Sawin PD, VanGilder JC: Spinal cord compression from metastatic Leydig's cell tumour of the testis: Case Report. Neurosurgery. 1996, 38: 407-411. 10.1097/00006123-199602000-00037.CrossRefPubMed
3.
go back to reference Godersky JC, Smoker WRK, Knutzon R: Use of magnetic resonance imaging in the evaluation of metastatic spinal disease. Neurosurgery. 1987, 21: 676-680. 10.1097/00006123-198711000-00013.CrossRefPubMed Godersky JC, Smoker WRK, Knutzon R: Use of magnetic resonance imaging in the evaluation of metastatic spinal disease. Neurosurgery. 1987, 21: 676-680. 10.1097/00006123-198711000-00013.CrossRefPubMed
4.
go back to reference Grem JL, Robins HI, Wilson KS, Gilchrist K, Trump DL: Metastatic Leydig cell tumor of the testis: Report of three cases and review of the literature. Cancer. 1986, 58: 2116-2119. 10.1002/1097-0142(19861101)58:9<2116::AID-CNCR2820580925>3.0.CO;2-X.CrossRefPubMed Grem JL, Robins HI, Wilson KS, Gilchrist K, Trump DL: Metastatic Leydig cell tumor of the testis: Report of three cases and review of the literature. Cancer. 1986, 58: 2116-2119. 10.1002/1097-0142(19861101)58:9<2116::AID-CNCR2820580925>3.0.CO;2-X.CrossRefPubMed
5.
go back to reference Bertram KA, Bratloff B, Hodges GF, Davidson H: Treatment of malignant Leydig cell tumour. Cancer. 1991, 68: 2324-2329. 10.1002/1097-0142(19911115)68:10<2324::AID-CNCR2820681036>3.0.CO;2-K.CrossRefPubMed Bertram KA, Bratloff B, Hodges GF, Davidson H: Treatment of malignant Leydig cell tumour. Cancer. 1991, 68: 2324-2329. 10.1002/1097-0142(19911115)68:10<2324::AID-CNCR2820681036>3.0.CO;2-K.CrossRefPubMed
6.
go back to reference Kim I, Young RH, Scully RE: Leydig cell tumours of the testis: A clinicopathological analysis of 40 cases and review of the literature. Am J Surg Pathol. 1985, 9: 177-192. 10.1097/00000478-198503000-00002.CrossRefPubMed Kim I, Young RH, Scully RE: Leydig cell tumours of the testis: A clinicopathological analysis of 40 cases and review of the literature. Am J Surg Pathol. 1985, 9: 177-192. 10.1097/00000478-198503000-00002.CrossRefPubMed
7.
go back to reference Mahon FB, Gosset F, Trinity RC, Madsen PO: Malignant interstitial cell testicular tumor. Cancer. 1973, 31: 1208-1212. 10.1002/1097-0142(197305)31:5<1208::AID-CNCR2820310525>3.0.CO;2-6.CrossRefPubMed Mahon FB, Gosset F, Trinity RC, Madsen PO: Malignant interstitial cell testicular tumor. Cancer. 1973, 31: 1208-1212. 10.1002/1097-0142(197305)31:5<1208::AID-CNCR2820310525>3.0.CO;2-6.CrossRefPubMed
8.
go back to reference Gilbert RW, Kim JH, Posner JB: Epidural spinal cord compression from metastatic tumor: Diagnosis and treatment. Ann Neurol. 1978, 3: 40-51. 10.1002/ana.410030107.CrossRefPubMed Gilbert RW, Kim JH, Posner JB: Epidural spinal cord compression from metastatic tumor: Diagnosis and treatment. Ann Neurol. 1978, 3: 40-51. 10.1002/ana.410030107.CrossRefPubMed
9.
go back to reference Hall AJ, Mackay NNS: The results of laminectomy for compression of the cord and cauda equina by extradural malignant tumour. J Bone Joint Surg Br. 1973, 55 (3): 497-505.PubMed Hall AJ, Mackay NNS: The results of laminectomy for compression of the cord and cauda equina by extradural malignant tumour. J Bone Joint Surg Br. 1973, 55 (3): 497-505.PubMed
10.
go back to reference White WA, Patterson RH, Bergland RM: Role of surgery in the treatment of spinal cord compression by metastatic neoplasm. Cancer. 1971, 27: 558-561. 10.1002/1097-0142(197103)27:3<558::AID-CNCR2820270307>3.0.CO;2-E.CrossRefPubMed White WA, Patterson RH, Bergland RM: Role of surgery in the treatment of spinal cord compression by metastatic neoplasm. Cancer. 1971, 27: 558-561. 10.1002/1097-0142(197103)27:3<558::AID-CNCR2820270307>3.0.CO;2-E.CrossRefPubMed
11.
go back to reference Abelson D, Bulaschenko H, Trommer PR, Valdes-Dapena : A Malignant interstitial-cell tumor of the testis treated with o,p'-DDD. Metabolism. 1966, 15: 242-256. 10.1016/0026-0495(66)90022-9.CrossRefPubMed Abelson D, Bulaschenko H, Trommer PR, Valdes-Dapena : A Malignant interstitial-cell tumor of the testis treated with o,p'-DDD. Metabolism. 1966, 15: 242-256. 10.1016/0026-0495(66)90022-9.CrossRefPubMed
12.
go back to reference Azer PC, Braunstein GD: Malignant Leydig cell tumor: Objective tumor response to o,p'-DDD. Cancer. 1981, 47: 1251-1255. 10.1002/1097-0142(19810315)47:6<1251::AID-CNCR2820470604>3.0.CO;2-R.CrossRefPubMed Azer PC, Braunstein GD: Malignant Leydig cell tumor: Objective tumor response to o,p'-DDD. Cancer. 1981, 47: 1251-1255. 10.1002/1097-0142(19810315)47:6<1251::AID-CNCR2820470604>3.0.CO;2-R.CrossRefPubMed
13.
go back to reference Davis S, DiMartino NA, Schneider G: Malignant interstitial cell carcinoma of the testis: Report of two cases with steroid synthetic profiles, response to therapy, and review of the literature. Cancer. 1981, 47: 425-431. 10.1002/1097-0142(19810115)47:2<425::AID-CNCR2820470234>3.0.CO;2-S.CrossRefPubMed Davis S, DiMartino NA, Schneider G: Malignant interstitial cell carcinoma of the testis: Report of two cases with steroid synthetic profiles, response to therapy, and review of the literature. Cancer. 1981, 47: 425-431. 10.1002/1097-0142(19810115)47:2<425::AID-CNCR2820470234>3.0.CO;2-S.CrossRefPubMed
14.
go back to reference Feldman PS, Kovacs K, Horvath E, Adelson GL: Malignant Leydig cell tumor: Clinical, histologic and electron microscopic features. Cancer. 1982, 49: 714-721. 10.1002/1097-0142(19820215)49:4<714::AID-CNCR2820490420>3.0.CO;2-A.CrossRefPubMed Feldman PS, Kovacs K, Horvath E, Adelson GL: Malignant Leydig cell tumor: Clinical, histologic and electron microscopic features. Cancer. 1982, 49: 714-721. 10.1002/1097-0142(19820215)49:4<714::AID-CNCR2820490420>3.0.CO;2-A.CrossRefPubMed
15.
go back to reference Tamoney HJ, Noriega A: Malignant interstitial cell tumour of the testis. Cancer. 1969, 24: 547-551. 10.1002/1097-0142(196909)24:3<547::AID-CNCR2820240318>3.0.CO;2-L.CrossRefPubMed Tamoney HJ, Noriega A: Malignant interstitial cell tumour of the testis. Cancer. 1969, 24: 547-551. 10.1002/1097-0142(196909)24:3<547::AID-CNCR2820240318>3.0.CO;2-L.CrossRefPubMed
16.
go back to reference Patchel RA, Tibbs PA, William RF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet. 2005, 366: 643-648. 10.1016/S0140-6736(05)66954-1.CrossRef Patchel RA, Tibbs PA, William RF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet. 2005, 366: 643-648. 10.1016/S0140-6736(05)66954-1.CrossRef
17.
go back to reference Bauer HC: Controversies in the surgical management of skeletal metastases. J Bone Joint Surg Br. 2005, 87: 608-617. 10.1302/0301-620X.87B5.16021.CrossRefPubMed Bauer HC: Controversies in the surgical management of skeletal metastases. J Bone Joint Surg Br. 2005, 87: 608-617. 10.1302/0301-620X.87B5.16021.CrossRefPubMed
Metadata
Title
Spinal cord compression by a solitary metastasis from a low grade leydig cell tumour: a case report and review of the literature
Authors
Efthimios P Samoladas
Ashraf S Anbar
Jonathan D Lucas
Hlias Fotiadis
Byron E Chalidis
Publication date
01-12-2008
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2008
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-6-75

Other articles of this Issue 1/2008

World Journal of Surgical Oncology 1/2008 Go to the issue