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Medical Oncology
Published in: Medical Oncology 2/2010

01-06-2010 | Review Article

Specific skin lesions in hairy cell leukemia at presentation: case report and review of literature

Authors: N. Čolović, M. Peruničić, V. Jurišić, M. Čolović

Published in: Medical Oncology | Issue 2/2010

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Abstract

Skin involvement in hairy cell leukemia (HCL) at presentation is a relatively rare manifestation of the disease. A 60-year-old male patient in whom cutaneous lesions were the initial manifestation of hairy cell leukemia together with leukocytosis, monocytopenia, massive splenomegaly, and leukemic maculopapulous infiltration of the almost whole skin is described. The present case is the forth mentioned in the literature with specify of leukocytosis in peripheral blood, consisting mostly of hairy cells. The patient was treated with two courses of 2-chlorodeoxiadenosine (2-CdA, Cladribine) and splenectomy and after this cutaneous lesion disappeared and general condition is improved.
Literature
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Lawrence DM, Sun NCJ, Mena R, Moss R. Cutaneous lesions in hairy cell leukemia. Case report and review of the literature. Arch Dermatol. 1983;119:322–5.CrossRefPubMed
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Arai E, et al. Specific skin lesions as the presenting symptom of hairy cell leukemia. Am J Clin Pathol. 1988;90:459–64.PubMed
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Bilsland D, Shariari S, Douglas WS, et al. Transient leukemia cutis in hairy-cell leukemia. Clin Exp Dermatol. 1991;16:207–9.CrossRefPubMed
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Zak P, Chrobak L, Podyimek K, Hejcmanova D, Voglova J, Dulicek P, et al. An unusual course in hairy-cell leukemia with marked abdominal lymphadenopathy, leukemic infiltration of the cornea and skin changes. Vnitr Lek. 1996;42:463–6.PubMed
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Metadata
Title
Specific skin lesions in hairy cell leukemia at presentation: case report and review of literature
Authors
N. Čolović
M. Peruničić
V. Jurišić
M. Čolović
Publication date
01-06-2010
Publisher
Springer US
Published in
Medical Oncology / Issue 2/2010
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-009-9246-4

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