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Radiation Oncology
Published in: Radiation Oncology 1/2013

Open Access 01-12-2013 | Research

Sonoporation as an enhancing method for boron neutron capture therapy for squamous cell carcinomas

Authors: Naofumi Yamatomo, Takaki Iwagami, Itsuro Kato, Shin-Ichiro Masunaga, Yoshinori Sakurai, Soichi Iwai, Mitsuhiro Nakazawa, Koji Ono, Yoshiaki Yura

Published in: Radiation Oncology | Issue 1/2013

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Abstract

Background

Boron neutron capture therapy (BNCT) is a selective radiotherapy that is dependent on the accumulation of 10B compound in tumors. Low-intensity ultrasound produces a transient pore on cell membranes, sonoporation, which enables extracellular materials to enter cells. The effect of sonoporation on BNCT was examined in oral squamous cell carcinoma (SCC) xenografts in nude mice.

Materials and methods

Tumor-bearing mice were administrated boronophenylalanine (BPA) or boronocaptate sodium (BSH) intraperitoneally. Two hours later, tumors were subjected to sonoporation using microbubbles followed by neutron irradiation.

Results

The 10B concentration was higher in tumors treated with sonoporation than in untreated tumors, although the difference was not significant in BPA. When tumors in mice that received BPA intraperitoneally were treated with sonoporation followed by exposure to thermal neutrons, tumor volume was markedly reduced and the survival rate was prolonged. Such enhancements by sonoporation were not observed in mice treated with BSH-mediated BNCT.

Conclusions

These results indicate that sonoporation enhances the efficiency of BPA-mediated BNCT for oral SCC. Sonoporation may modulate the microlocalization of BPA and BSH in tumors and increase their intracellular levels.
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Metadata
Title
Sonoporation as an enhancing method for boron neutron capture therapy for squamous cell carcinomas
Authors
Naofumi Yamatomo
Takaki Iwagami
Itsuro Kato
Shin-Ichiro Masunaga
Yoshinori Sakurai
Soichi Iwai
Mitsuhiro Nakazawa
Koji Ono
Yoshiaki Yura
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2013
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/1748-717X-8-280

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