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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2021

Open Access 01-12-2021 | Solid Tumor | Review

Integrins regulate stemness in solid tumor: an emerging therapeutic target

Authors: Jiangling Xiong, Lianlian Yan, Cheng Zou, Kai Wang, Mengjie Chen, Bin Xu, Zhipeng Zhou, Dingxiao Zhang

Published in: Journal of Hematology & Oncology | Issue 1/2021

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Abstract

Integrins are the adhesion molecules and transmembrane receptors that consist of α and β subunits. After binding to extracellular matrix components, integrins trigger intracellular signaling and regulate a wide spectrum of cellular functions, including cell survival, proliferation, differentiation and migration. Since the pattern of integrins expression is a key determinant of cell behavior in response to microenvironmental cues, deregulation of integrins caused by various mechanisms has been causally linked to cancer development and progression in several solid tumor types. In this review, we discuss the integrin signalosome with a highlight of a few key pro-oncogenic pathways elicited by integrins, and uncover the mutational and transcriptomic landscape of integrin-encoding genes across human cancers. In addition, we focus on the integrin-mediated control of cancer stem cell and tumor stemness in general, such as tumor initiation, epithelial plasticity, organotropic metastasis and drug resistance. With insights into how integrins contribute to the stem-like functions, we now gain better understanding of the integrin signalosome, which will greatly assist novel therapeutic development and more precise clinical decisions.
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Metadata
Title
Integrins regulate stemness in solid tumor: an emerging therapeutic target
Authors
Jiangling Xiong
Lianlian Yan
Cheng Zou
Kai Wang
Mengjie Chen
Bin Xu
Zhipeng Zhou
Dingxiao Zhang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2021
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-021-01192-1

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