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Skeletal Radiology

Open Access 17-01-2024 | Soft Tissue Tumor | Review Article

Recent advances in molecular profiling of bone and soft tissue tumors

Authors: D. Baumhoer, J. Hench, F. Amary

Published in: Skeletal Radiology

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Abstract

The molecular characterization of soft tissue and bone tumors is a rapidly evolving field that has changed the perspective of how these tumors are diagnosed today. Morphology and clinico-radiological context still represent the cornerstone of diagnostic considerations but are increasingly complemented by molecular data that aid in objectifying and confirming the classification. The spectrum of analyses comprises mutation or gene fusion specific immunohistochemical antibodies, fluorescence in situ hybridization, DNA and RNA sequencing as well as CpG methylation profiling. This article provides an overview of which tools are presently available to characterize bone and soft tissue neoplasms molecularly, what limitations should be considered, and what conclusions can be drawn from the individual findings.
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Metadata
Title
Recent advances in molecular profiling of bone and soft tissue tumors
Authors
D. Baumhoer
J. Hench
F. Amary
Publication date
17-01-2024
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-024-04584-9