ASO Author Reflections: Towards Patient-Tailored Management of Extremity Soft Tissue Sarcoma

Excerpt

A multimodality approach is often used in the management of high-grade soft tissue sarcoma of the extremity (eSTS). Limb-sparing surgery is the keystone of eSTS management, often accompanied with radiotherapy (RTX) and/or chemotherapy (CTX). The National Comprehensive Cancer Network (NCCN) and European Society for Medical Oncology (ESMO) guideline recommend RTX and CTX in selected groups of high-risk patients.1,2 However, the identification of these high-risk patients who benefit from perioperative treatment remains challenging. In the last decade, several prognostic tools and prognostic gene expression profiles have been developed to facilitate clinical decision-making for the indication of multimodality therapy. This marks a shift from a one-size-fits-all approach to a patient-tailored approach for the management and surveillance of eSTS. …