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Diabetologia
Published in: Diabetologia 2/2014

01-02-2014 | Article

Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes

Authors: Archana Tare, Jacqueline M. Lane, Brian E. Cade, Struan F. A. Grant, Ting-hsu Chen, Naresh M. Punjabi, Diane S. Lauderdale, Phyllis C. Zee, Sina A. Gharib, Daniel J. Gottlieb, Frank A. J. L. Scheer, Susan Redline, Richa Saxena

Published in: Diabetologia | Issue 2/2014

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Abstract

Aims/hypothesis

Short and long sleep duration are associated with increased risk of type 2 diabetes. We aimed to investigate whether genetic variants for fasting glucose or type 2 diabetes associate with short or long sleep duration and whether sleep duration modifies the association of genetic variants with these traits.

Methods

We examined the cross-sectional relationship between self-reported habitual sleep duration and prevalence of type 2 diabetes in individuals of European descent participating in five studies included in the Candidate Gene Association Resource (CARe), totalling 1,474 cases and 8,323 controls. We tested for association of 16 fasting glucose-associated variants, 27 type 2 diabetes-associated variants and aggregate genetic risk scores with continuous and dichotomised (≤5 h or ≥9 h) sleep duration using regression models adjusted for age, sex and BMI. Finally, we tested whether a gene × behaviour interaction of variants with sleep duration had an impact on fasting glucose or type 2 diabetes risk.

Results

Short sleep duration was significantly associated with type 2 diabetes in CARe (OR 1.32; 95% CI 1.08, 1.61; p = 0.008). Variants previously associated with fasting glucose or type 2 diabetes and genetic risk scores were not associated with sleep duration. Furthermore, no study-wide significant interaction was observed between sleep duration and these variants on glycaemic traits. Nominal interactions were observed for sleep duration and PPARG rs1801282, CRY2 rs7943320 and HNF1B rs4430796 in influencing risk of type 2 diabetes (p < 0.05).

Conclusions/interpretation

Our findings suggest that differences in habitual sleep duration do not mediate or modify the relationship between common variants underlying glycaemic traits (including in circadian rhythm genes) and diabetes.
Appendix
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Metadata
Title
Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes
Authors
Archana Tare
Jacqueline M. Lane
Brian E. Cade
Struan F. A. Grant
Ting-hsu Chen
Naresh M. Punjabi
Diane S. Lauderdale
Phyllis C. Zee
Sina A. Gharib
Daniel J. Gottlieb
Frank A. J. L. Scheer
Susan Redline
Richa Saxena
Publication date
01-02-2014
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 2/2014
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-013-3110-y

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