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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Sleep and Breathing
Published in: Sleep and Breathing 2/2022

06-08-2021 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Predictors of weight loss in obese patients with obstructive sleep apnea

Authors: Thomas J. Altree, Delwyn J. Bartlett, Nathaniel S. Marshall, Camilla M. Hoyos, Craig L. Phillips, Callum Birks, Aran Kanagaratnam, Anna Mullins, Yasmina Serinel, Keith K. H. Wong, Brendon J. Yee, Ronald R. Grunstein, Elizabeth A. Cayanan

Published in: Sleep and Breathing | Issue 2/2022

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Abstract

Purpose

Consistent predictors of weight loss outcomes with very low-energy diets (VLEDs) in obstructive sleep apnea (OSA) have not been identified. This study aimed to identify variables predictive of weight loss success in obese patients with OSA undertaking an intensive weight loss programme.

Methods

We analysed biological, psychological, and behavioural variables as potential predictors of weight loss in obese patients with OSA after a 2-month VLED followed by one of two 10-month weight loss maintenance diets. Actigraphy, in-lab polysomnography, urinary catecholamines, and various psychological and behavioural variables were measured at baseline, 2, and 12 months. Spearman’s correlations analysed baseline variables with 2-month weight loss, and 2-month variables with 2–12 month-weight change.

Results

Forty-two patients completed the VLED and thirty-eight completed the maintenance diets. Actigraphy data revealed that late bedtime (rs =  − 0.45, p =  < 0.01) was correlated with 2-month weight loss. The change in the time that participants got out of bed (rise-time) from baseline to two months was also correlated with 2-month weight loss (rs = 0.36, p = 0.03). The Impact of Weight on Quality of Life-Lite questionnaire (IWQOL) Public Distress domain (rs =  − 0.54, p =  < 0.01) and total (rs =  − 0.38, p = 0.02) scores were correlated with weight loss maintenance from 2 to 12 months.

Conclusions

Results from this small patient sample reveal correlations between actigraphy characteristics and weight loss in obese patients with OSA. We suggest the IWQOL may also be a useful clinical tool to identify OSA patients at risk of weight regain after initial weight loss.

Clinical trial registration

This clinical trial was prospectively registered on 18/02/2013 with the Australia and New Zealand Clinical Trials Registry (ACTRN12613000191796).

Public Registry Title

Sleep, Lifestyle, Energy, Eating, Exercise Program for the management of sleep apnea patients indicated for weight loss treatment: A randomised, controlled pilot study.
Appendix
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Metadata
Title
Predictors of weight loss in obese patients with obstructive sleep apnea
Authors
Thomas J. Altree
Delwyn J. Bartlett
Nathaniel S. Marshall
Camilla M. Hoyos
Craig L. Phillips
Callum Birks
Aran Kanagaratnam
Anna Mullins
Yasmina Serinel
Keith K. H. Wong
Brendon J. Yee
Ronald R. Grunstein
Elizabeth A. Cayanan
Publication date
06-08-2021
Publisher
Springer International Publishing
Published in
Sleep and Breathing / Issue 2/2022
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-021-02455-4

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