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Open Access 01-12-2011 | Research article

Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry

Authors: Thomas Scheffold, Silke Kullmann, Andreas Huge, Priska Binner, Hermann R Ochs, Wolfgang Schöls, Joachim Thale, Wolfgang Motz, Franz Josef Hegge, Christoph Stellbrink, Thomas Dorsel, Hartmut Gülker, Hubertus Heuer, Wilfried Dinh, Monika Stoll, Georg Haltern, Forschungsverbund Herz-Kreislauf in NRW (Research Consortium Heart and Circulation in North Rhine-Westphalia)

Published in: BMC Cardiovascular Disorders | Issue 1/2011

Abstract

Background

Recent genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) and myocardial infarction (MI). The 9p21.3 locus was verified by numerous replication studies to be the first common locus for CAD and MI. In the present study, we investigated whether six single nucleotide polymorphisms (SNP) rs1333049, rs1333040, rs10757274, rs2383206, rs10757278, and rs2383207 representing the 9p21.3 locus were associated with the incidence of an acute MI in patients with the main focus on the familial aggregation of the disease.

Methods

The overall cohort consisted of 976 unrelated male patients presenting with an acute coronary syndrome (ACS) with ST-elevated (STEMI) as well as non-ST-elevated myocardial infarction (NSTEMI). Genotyping data of the investigated SNPs were generated and statistically analyzed in comparison to previously published findings of matchable control cohorts.

Results

Statistical evaluation confirmed a highly significant association of all analyzed SNP's with the occurrence of MI (p < 0.0001; OR: 1.621-2.039). When only MI patients with a positive family disposition were comprised in the analysis a much stronger association of the accordant risk alleles with incident disease was found with odds ratios up to 2.769.

Conclusions

The findings in the present study confirmed a strong association of the 9p21.3 locus with MI particularly in patients with a positive family history thereby, emphasizing the pathogenic relevance of this locus as a common genetic cardiovascular risk factor.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2261/11/9/prepub

Title: Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry
Authors: Thomas Scheffold
Silke Kullmann
Andreas Huge
Priska Binner
Hermann R Ochs
Wolfgang Schöls
Joachim Thale
Wolfgang Motz
Franz Josef Hegge
Christoph Stellbrink
Thomas Dorsel
Hartmut Gülker
Hubertus Heuer
Wilfried Dinh
Monika Stoll
Georg Haltern
Forschungsverbund Herz-Kreislauf in NRW (Research Consortium Heart and Circulation in North Rhine-Westphalia)
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2011
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/1471-2261-11-9

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Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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