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01-06-2018 | Case Report

Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications

Authors: Bin Xu, Ruth Aryeequaye, Lu Wang, Nora Katabi

Published in: Head and Neck Pathology | Issue 2/2018

Abstract

Secretory carcinoma (SC) is a recently described salivary gland carcinoma with characteristic ETV6-NTRK3 fusion. In this case report, we described a SC of the maxillary sinus that underwent high grade transformation in a 61-year-old patient. The diagnosis was confirmed by the presence of ETV6 translocation. Within the sinonasal tract, SC is an important differential diagnosis especially of sinonasal adenocarcinoma, non-intestinal type (non-ITAC), as these two entities bears histologic and immunophenotypic similarity. Distinction between these two tumors can be challenging based on the morphology alone and may require additional immunohistochemical and molecular studies. It is important to recognize that SC can occur in the sinonasal tract as correctly diagnosing SC may be prognostic relevant and may provide new targeted therapeutic avenues for these patients.

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Title: Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications
Authors: Bin Xu
Ruth Aryeequaye
Lu Wang
Nora Katabi
Publication date: 01-06-2018
Publisher: Springer US
Published in: Head and Neck Pathology / Issue 2/2018
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-017-0855-5

At a glance: The STEP trials

Springer Medicine

Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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