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01-06-2018 | Case Report

A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands

Authors: Vincent Cracolici, Raymon H. Grogan, Madina Sukhanova, Jason X. Cheng, Sandeep Gurbuxani, Nicole A. Cipriani

Published in: Head and Neck Pathology | Issue 2/2018

Abstract

Involvement of the parathyroid glands by non-parathyroid neoplasia is an infrequent event. Rare cases of metastases to the parathyroid gland have been reported in parathyroidectomies and autopsies of patients with known solid or hematopoietic malignancies. Here, we present a case of atypical clonal plasma cells incidentally identified within a parathyroid adenoma resected for hyperparathyroidism and hypercalcemia, which served as the sentinel event for a subsequent diagnosis of plasma cell myeloma. To our knowledge, this is the only reported case of a hematopoietic malignancy involving a parathyroid adenoma and the only reported case of malignant hematopoietic cells initially detected in parathyroidectomy.

Applewhite MK, White MG, Xiong M, Pasternak JD, Abdulrasool L, Ogawa L, Suh I, Gosnell JE, Kaplan EL, Duh Q, Angelos P, Shen WT, Grogan RH. Incidence, risk factors, and clinical outcomes of incidental parathyroidectomy during thyroid surgery. Ann Surg Oncol. 2016. doi:10.1245/s10434-016-5439-1.PubMedCrossRef

Fulciniti F, Pezzullo L, Chiofalo MG, Butera D, Losito NS, Tommaselli AP, Botti G. Metastatic breast carcinoma to parathyroid adenoma on fine needle cytology sample: report of a case. Diagn Cytopathol. 2011. doi:10.1002/dc.21528.CrossRefPubMed

Inoshita T, Laurain AR. Tumor-to-tumor metastasis- malignant melanoma metastatic to parathyroid adenoma. Mil Med. 1985;150(6):323–5.CrossRefPubMed

Lee SH, Kim BH, Bae MJ, Yi YS, Kim WJ, Jeon YK, Kim SS, Kim YK, Kim IJ. Concurrence of primary hyperparathyroidism and metastatic breast carcinoma affected a parathyroid gland. J Clin Endocrinol Metab. 2013. doi:10.1210/jc.2013-1227.CrossRefPubMedPubMedCentral

Lee HE, Kim DH, Cho YH, Kim K, Chae SW, Sohn JH. Tumor-to-tumor metastasis: hepatocellular carcinoma metastatic to parathyroid adenoma. Pathol Int. 2011. doi:10.1111/j.1440-1827.2011.02707.x.CrossRefPubMed

Boixeda D, Pais JR, Rodriguez-garcia JL, Garcia-gonzalez M, Cuesta C, Moreno A, Monroy C. Hepatocarcinoma metastatic to a parathyroid adenoma. Diagn Oncol. 1991;1(5):316–9.

Woolner LB, Keating FR, Black BM. Primary hyperparathyroidism and metastatic breast carcinoma- a case in which breast carcinoma metastasized to a parathyroid adenoma. Cancer. 1958;11(5):975–9.CrossRefPubMed

Schwartz IS, Feld HJ, Imberman MM, Schwartz AE. Hypernephroma metastatic to a parathyroid adenoma eighteen years after nephrectomy. Mt Sinai J Med. 1982;49(6):499–503.PubMed

Margolis CI, Goldenberg VE. Breast carcinoma metastatic to parathyroid adenoma. N Y State J Med. 1969;69(5):702–3.PubMed

10.

Venkatraman L, Kalangutkar A, Russell CF. Primary hyperparathyroidism and metastatic carcinoma within parathyroid gland. J Clin Pathol. 2007. doi:10.1136/jcp.2005.035352.PubMedCentralCrossRefPubMed

11.

Shifrin A, LiVolsi V, Shifrin-Douglas S, Zheng M, Erler B, Matulewicz T, Davis J. Primary and metastatic parathyroid malignancies: a rare or underdiagnosed condition? J Clin Endocrinol Metab. 2015. doi:10.1210/jc.2014-2760.PubMedCentralCrossRefPubMed

12.

Benisovich VI, Rybak BJ, Ross FA. A case of adenocarcinoma of the lung associated with a neck mass and hypercalcemia. Cancer. 1991;68:1106–8.CrossRefPubMed

13.

Horowitz CA, Laird Myers WP, Foote FW. Secondary malignant tumors of the parathyroid glands: report of two cases with associated hypoparathyroidism. Am J Med. 1972. doi:10.1016/0002-9343(72)90086-1.CrossRef

14.

Bauer JL, Toluie S, Thompson LDR. Metastases to the parathyroid glands: a comprehensive literature review of 127 reported cases. Head and Neck Pathol. 2017. doi:10.1007/s/12105-017-0850-x.CrossRef

15.

Fraser WD, Hyperparathyroidism. Lancet. 2009. doi:10.1016/s0140-6736(09)60507-9.CrossRefPubMed

16.

Zarebczan B, McDonald R, Rajamanickam V, Leverson G, Chen H, Sippel RS. Training our future endocrine surgeons: a look at the endocrine surgery operative experience of U.S. surgical residents. Surgery. 2010. doi:10.1016/j.surg.2010.09.032.PubMedPubMedCentralCrossRef

17.

DeLellis RA. Parathyroid tumors and related disorders. Mod Path. 2011. doi:10.1038/modpathol.2010.132.CrossRef

18.

Hill K, Diaz J, Hageman IS, Chernock RD. Multiple myeloma presenting as massive amyloid deposition in a parathyroid gland associated with amyloid goiter: a medullary thyroid carcinoma mimic on intra-operative frozen section. Head Neck Pathol. 2017. doi:10.1007/s12105-017-0853-7.PubMedCrossRefPubMedCentral

19.

Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78:21–33.CrossRefPubMed

20.

Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol. 2010. doi:10.1093/annonc/mdp329.PubMedCrossRef

21.

Otsuka F, Hayakawa N, Ogura T, Kataoka H, Kawashima M, Mimura Y, Yamauchi T, Kashihara N, Kageyama J, Makino H. A case of primary hyperparathyroidism accompanying multiple myeloma. Endocr J. 1997;44(1):105–9.CrossRefPubMed

22.

Fery-Blanco C, Prati C, Ornetti P, Bevalot J, Streit G, Toussirot E, Wendling D. Hypercalcemia of double origin: association of multiple myeloma and ectopic parathyroidal adenoma. Revue De Medecine Interne. 2007. doi:10.1016/j.revmed.2007.02.007.CrossRefPubMed

23.

Hussain N, Khan M, Natarajan A, Mohammedabdul M, Mustafa U, Yedulla K, Mirrakhimov AE. A case of multiple myeloma coexisting with primary hyperparathyroidism and review of the literature. Case Rep Oncol Med. 2013. doi:10.1155/2013/420565.CrossRefPubMedPubMedCentral

24.

Goto S, Yoshioka M, Nagai K, Abe A, Murakawa E, Yamazaki N, Koyama T, Sekiya M. Primary hyperparathyroidism associated with multiple myeloma. Intern Med. 1995. doi:10.2169/internalmedicine.34.988.CrossRefPubMed

25.

Khandwala HM, Boctor MA. Multiple myeloma presenting with recurrent hypercalcemia in a patient with a history of primary hyperparathyroidism: report of case and review of literature. Endocr Pract. 2004. doi:10.4158/EP.10.4.345.PubMedCrossRef

Title: A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands
Authors: Vincent Cracolici
Raymon H. Grogan
Madina Sukhanova
Jason X. Cheng
Sandeep Gurbuxani
Nicole A. Cipriani
Publication date: 01-06-2018
Publisher: Springer US
Published in: Head and Neck Pathology / Issue 2/2018
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-017-0861-7

At a glance: The STEP trials

Springer Medicine

A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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