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Journal of Assisted Reproduction and Genetics

Published in:

01-01-2012 | Genetics

Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men

Authors: Toshinobu Miyamoto, Akira Tsujimura, Yasushi Miyagawa, Eitetsu Koh, Mikio Namiki, Michiharu Horikawa, Yasuaki Saijo, Kazuo Sengoku

Published in: Journal of Assisted Reproduction and Genetics | Issue 1/2012

Abstract

Purpose

To investigate the association between SEPTIN12 gene variants and the risk of azoospermia caused by meiotic arrest.

Methods

Mutational analysis of the SEPTIN12 gene was performed using DNA from 30 Japanese patients with azoospermia by meiotic arrest and 140 fertile male controls.

Results

The frequencies of the c.204G>C (Gln38His) allele and the CC genotype were significantly higher in patients than in fertile controls (p < 0.05).

Conclusion

The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest.

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Title: Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men
Authors: Toshinobu Miyamoto
Akira Tsujimura
Yasushi Miyagawa
Eitetsu Koh
Mikio Namiki
Michiharu Horikawa
Yasuaki Saijo
Kazuo Sengoku
Publication date: 01-01-2012
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 1/2012
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9679-5

At a glance: The STEP trials

Springer Medicine

Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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