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Published in: Journal of Gastrointestinal Cancer 1/2010

01-03-2010 | Original Research

Simultaneous Treatment of Unresectable Hepatocelluar Carcinoma and Hepatic Artery Aneurysm, Case Report

Authors: Mostafa Hashim, Ahmed A. S. Salem

Published in: Journal of Gastrointestinal Cancer | Issue 1/2010

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Abstract

Introduction

Hepatic artery aneurysm is uncommon with an estimated incidence of less than 0.25%. Because most patients are asymptomatic, the diagnosis is usually made as an incidental finding on imaging studies performed for other reasons. Because of their propensity to rupture with potential catastrophic intraperitoneal hemorrhage, early diagnosis is important. Herein, relatively asymptomatic aneurysm of the common hepatic artery mostly of atherosclerotic etiology is presented. The importance of imaging findings in the diagnosis of this condition is discussed and relevant literature is reviewed (1, 2). Hepatocellular carcinoma (HCC) ranks among the most common malignancies worldwide, and the prognosis for patients with HCC is typically poor. Chemoembolization has become the mainstay of treatment for patients with unresectable HCC. Transcatheter arterial chemoembolization is intended to deliver a highly concentrated dose of chemotherapy to tumor cells, prolong the contact time between the chemotherapeutic agents and the cancer cells, and minimize systemic toxicity. Ideally, achieving these goals will result in a tumor shrinkage, symptomatic relief, improved quality of life, and increased patient survival (3).

Methods

We will present a case of male patient, 72 years old, who was referred for transcatheter arterial chemoembolization for unresectable hepatocelluar carcinoma.

Results

Helical CT scan showed right lobe mass infiltrating the peritoneum with enhancement in the early arterial phase together with hepatic artery aneurysm that was successfully treated at the same time using emulsion of N-butyl cyanoacylate and lipodol with a concentration of 1:1.

Conclusion

Hepatic artery aneurysms are uncommon lesions that have varied clinical presentations. Early diagnosis is essential because the natural tendency of the lesion is to rupture into peritoneal cavity or surrounding organs. Chemoembolization has become the mainstay of treatment for patients with unresectable HCC. Our case is notable, because atherosclerotic aneurysms of the hepatic artery are extremely rare with very few cases reported so far and to diagnose a hepatic artery aneurysm and to treat it in one setting with chemoembolization of unresectable HCC without rupture of the aneurysm is also unusual.
Literature
1.
go back to reference Bachar GN, Belenky A, Lubovsky L, et al. Sonographic diagnosis of a giant aneurysm of the common hepatic artery. J Clin Ultrasound. 2002;30:300–2.CrossRefPubMed Bachar GN, Belenky A, Lubovsky L, et al. Sonographic diagnosis of a giant aneurysm of the common hepatic artery. J Clin Ultrasound. 2002;30:300–2.CrossRefPubMed
2.
go back to reference Parmar H, Shah J, Shah B, et al. Imaging findingsinagianthepaticartery aneurysm. J Postgrad Med. 2000;46:104–5.PubMed Parmar H, Shah J, Shah B, et al. Imaging findingsinagianthepaticartery aneurysm. J Postgrad Med. 2000;46:104–5.PubMed
3.
go back to reference Mathupala SP, Rempel A, Pedersen PL. Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J Biol Chem. 2001;276:43407–12.CrossRefPubMed Mathupala SP, Rempel A, Pedersen PL. Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J Biol Chem. 2001;276:43407–12.CrossRefPubMed
4.
go back to reference Chandramohan C, Khan AN, Fitzgerald S, et al. Sonographic diagnosis and follow-up of idiopathic hepatic artery aneurysm, an unusual cause of obstructive jaundice. J Clin Ultrasound. 2001;29:466–71.CrossRefPubMed Chandramohan C, Khan AN, Fitzgerald S, et al. Sonographic diagnosis and follow-up of idiopathic hepatic artery aneurysm, an unusual cause of obstructive jaundice. J Clin Ultrasound. 2001;29:466–71.CrossRefPubMed
5.
go back to reference O’Driscoll D, Olliff SP, Olliff JF. Hepaticarteryaneurysm. Br J Radiol. 1999;72:1018–25.PubMed O’Driscoll D, Olliff SP, Olliff JF. Hepaticarteryaneurysm. Br J Radiol. 1999;72:1018–25.PubMed
6.
go back to reference Komori K, Sonoda T, Ikeda Y, et al. Demonstration of hepatic artery aneurysm by substraction angiography. Am J Gastroenterol. 1991;86:1650–3.PubMed Komori K, Sonoda T, Ikeda Y, et al. Demonstration of hepatic artery aneurysm by substraction angiography. Am J Gastroenterol. 1991;86:1650–3.PubMed
7.
go back to reference Sunthornlekhla B, Chandaragga S, Sundusadee K, et al. Hepatic artery aneurysm: a case report. J Med Assoc Thai. 1996;79:60–4.PubMed Sunthornlekhla B, Chandaragga S, Sundusadee K, et al. Hepatic artery aneurysm: a case report. J Med Assoc Thai. 1996;79:60–4.PubMed
8.
go back to reference Paolella LP, Scola FH, Cronan JJ. Hepatic artery aneurysm: an ultrasound diagnosis. J Clin Ultrasound. 1985;13:360–2.CrossRefPubMed Paolella LP, Scola FH, Cronan JJ. Hepatic artery aneurysm: an ultrasound diagnosis. J Clin Ultrasound. 1985;13:360–2.CrossRefPubMed
9.
go back to reference Rigaux A, Vossen P, Van Baarle A, et al. Hepatic artery aneurysm: ultrasonic diagnosis. J Clin Ultrasound. 1986;14:401–3.CrossRefPubMed Rigaux A, Vossen P, Van Baarle A, et al. Hepatic artery aneurysm: ultrasonic diagnosis. J Clin Ultrasound. 1986;14:401–3.CrossRefPubMed
10.
go back to reference Stokland E, Wihed A, Ceder S, et al. Ultrasonic diagnosis of an aneurysm of the common hepatic artery. J Clin Ultrasound. 1985;10:360–2. Stokland E, Wihed A, Ceder S, et al. Ultrasonic diagnosis of an aneurysm of the common hepatic artery. J Clin Ultrasound. 1985;10:360–2.
11.
go back to reference Warshauer DM, Keefe B, Maura MA. Intrahepatic hepatic artery aneurysm: computed tomography and color-flowDopplerultrasound findings. Gastrointest Radiol. 1991;16:175–7.CrossRefPubMed Warshauer DM, Keefe B, Maura MA. Intrahepatic hepatic artery aneurysm: computed tomography and color-flowDopplerultrasound findings. Gastrointest Radiol. 1991;16:175–7.CrossRefPubMed
12.
go back to reference Barkin JS, Potash JB, Hernandez M, et al. Hepatic artery aneurysm simulating a cystic mass of the pancreas. Dig Dis Sci. 1987;32:1196–200.CrossRefPubMed Barkin JS, Potash JB, Hernandez M, et al. Hepatic artery aneurysm simulating a cystic mass of the pancreas. Dig Dis Sci. 1987;32:1196–200.CrossRefPubMed
13.
go back to reference El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340:745–50.CrossRefPubMed El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340:745–50.CrossRefPubMed
14.
go back to reference El-Serag HB, Mason AC. Risk factors for the rising rates of primary liver cancer in the United States. Arch Intern Med. 2000;160:3227–230.CrossRefPubMed El-Serag HB, Mason AC. Risk factors for the rising rates of primary liver cancer in the United States. Arch Intern Med. 2000;160:3227–230.CrossRefPubMed
15.
go back to reference Ono Y, Yoshimasu T, Ashikaga R, et al. Long-term results of lipiodol-transcatheter arterial embolization with cisplatin or doxorubicin for unresectable hepatocellular carcinoma. Am J Clin Oncol. 2000;23:564–8.CrossRefPubMed Ono Y, Yoshimasu T, Ashikaga R, et al. Long-term results of lipiodol-transcatheter arterial embolization with cisplatin or doxorubicin for unresectable hepatocellular carcinoma. Am J Clin Oncol. 2000;23:564–8.CrossRefPubMed
16.
go back to reference Takayasu K, Shima Y, Muramatsu Y, et al. Hepatocellular carcinoma: Treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology. 1987;163:345–51.PubMed Takayasu K, Shima Y, Muramatsu Y, et al. Hepatocellular carcinoma: Treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology. 1987;163:345–51.PubMed
Metadata
Title
Simultaneous Treatment of Unresectable Hepatocelluar Carcinoma and Hepatic Artery Aneurysm, Case Report
Authors
Mostafa Hashim
Ahmed A. S. Salem
Publication date
01-03-2010
Publisher
Springer US
Published in
Journal of Gastrointestinal Cancer / Issue 1/2010
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-009-9117-4

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