Top

09-05-2024 | Research

Simultaneous Exposure to Noise and Toluene Induces Oxidative and Inflammatory Damage in the Heart of Wistar Rats: Therapeutic Potential of Olea europaea L. Leaf Extract

Authors: Takoua Ben Attia, Afef Nahdi, Mabrouk Horchani, Ridha Ben Ali, Hichem Ben Jannet, Said Galai, Michèle Véronique Elmay, Abada Mhamdi

Published in: Cardiovascular Toxicology

Abstract

Workers in occupational settings often face simultaneous exposure to multiple risk factors, including noise and chemicals. This study aimed to investigate the effects of combined exposure to noise and toluene on the cardiac health of rats, with a focus on assessing the potential mitigating effects of Olea europaea L. (OLE) leaf extract (40 mg/kg/day). The evaluation involved scrutinizing biochemical and hematological markers, quantifying oxidative stress levels, determining proinflammatory cytokines in the serum, and conducting an in silico Docking studies. Forty-two male Wistar rats were divided into eight groups-(n = 6/group):-Control-group-(C),-OLE-group-(Rats administered OLE), NT-group (rats co-exposed to noise and toluene), NT-4 group-(rats co-exposed to noise and toluene four weeks after the exposure period), NT + OLE1-group (rats co-exposed to noise and toluene treated with OLE for one week), NT + OLE2-group-(rats co-exposed to noise and toluene treated with OLE for two weeks), NT + OLE3-group-(rats co-exposed to noise and toluene treated with OLE for three weeks), and NT + OLE4-group (rats co-exposed to noise and toluene treated with OLE for four weeks). The results revealed that combined exposure to noise and toluene led to oxidative damage and increased serum levels of proinflammatory cytokines. However, OLE treatment attenuated these effects by reducing lipid peroxidation and enhancing catalase and superoxide dismutase activities. Additionally, OLE treatment significantly decreased proinflammatory cytokine levels compared to the noise and toluene co-exposed group. The study highlighted the potential of OLE to attenuate the adverse effects of combined exposure to noise and toluene, attributed to its anti-inflammatory and antioxidant properties.

Available only for authorised users

Assunta, C., Ilaria, S., Gianfranco, T., Teodorico, C., Carmina, S., Anastasia, S., Roberto, G., Francesco, T., & Valeria, R. M. (2015). Noise and cardiovascular effects in workers of the sanitary fixtures industry. International Journal of Hygiene and Environmental Health, 218(1), 163–168. https://doi.org/10.1016/j.ijheh.2014.09.007CrossRefPubMed

Skogstad, M., Johannessen, H. A., Tynes, T., Mehlum, I. S., Nordby, K. C., & Lie, A. (2016). A systematic review of the cardiovascular effects of occupational noise. Occupational medicine (Oxford, England), 66(1), 10–16. https://doi.org/10.1093/occmed/kqv148CrossRefPubMed

Brahem, A., Riahi, S., Chouchane, A., Kacem, I., Maalel, O. E., Maoua, M., & Mrizek, N. (2019). Impact du bruit professionnel sur le développement de l’hypertensionartérielle. enquêteréalisée au sein d’une centrale de production d’électricité et de gazenTunisie. Annales de Cardiologie et d’Angéiologie. https://doi.org/10.1016/j.ancard.2018.10.008CrossRefPubMed

Milovanović, A., Jakovljević, B., Milovanović, J., Paunović, K., Ilić, D., Torbica, N., Corac, A., Samardzic, S., & Blagojević, T. (2007). Morbidity patterns of workers employed in pharmaceutical-chemical industry. Srpski arhiv za celokupno lekarstvo, 135(3–4), 184–190. https://doi.org/10.2298/sarh0704184mCrossRefPubMed

Zhang, Z., Liu, X., Guo, C., Zhang, X., Zhang, Y., Deng, N., Lai, G., Yang, A., Huang, Y., Dang, S., Zhu, Y., Xing, X., Xiao, Y., & Deng, Q. (2022). Hematological effects and benchmark doses of long-term co-exposure to benzene, toluene, and xylenes in a follow-up study on petrochemical workers. Toxics, 10(9), 502. https://doi.org/10.3390/toxics10090502CrossRefPubMedPubMedCentral

Kumar, S., Sharma, A., & Kshetrimayum, C. (2019). Environmental & occupational exposure & female reproductive dysfunction. The Indian Journal of Medical Research, 150(6), 532–545. https://doi.org/10.4103/ijmr.IJMR_1652_17CrossRefPubMedPubMedCentral

Crossin, R., Qama, A., Andrews, Z. B., Lawrence, A. J., & Duncan, J. R. (2019). The effect of adolescent inhalant abuse on energy balance and growth. Pharmacology Research & Perspectives, 7(4), e00498. https://doi.org/10.1002/prp2.498CrossRef

Filley, C. M., Halliday, W., & Kleinschmidt-Demasters, B. K. (2004). The effects of toluene on the central nervous system. Journal of Neuropathology & Experimental Neurology, 63(1), 1–12. https://doi.org/10.1093/jnen/63.1.1CrossRef

Ayan, M., Tas, U., Sogut, E., Kuloglu, T., Cayli, S., Kocaman, N., Karaca, Z. I., & Sahin, M. (2013). The apoptotic effect of a high dose of toluene on liver tissue during the acute phase: An experimental study. Toxicology and industrial health, 29(8), 728–736. https://doi.org/10.1177/0748233712442731CrossRefPubMed

10.

Tas, U., Ogeturk, M., Kuloglu, T., Sapmaz, H. I., Kocaman, N., Zararsiz, I., & Sarsilmaz, M. (2013). HSP70 immune reactivity and TUNEL positivity in the liver of toluene-inhaled and melatonin-treated rats. Toxicology and Industrial Health, 29(6), 514–522. https://doi.org/10.1177/0748233712440138CrossRefPubMed

11.

Ballantyne, B. (2016). Perspectives in basic and applied toxicology. Wiltshire, England: Elsevier Science.

12.

Taamalli, A., Arráez-Román, D., Zarrouk, M., Valverde, J., Segura-Carretero, A., & Fernández-Gutiérrez, A. (2012). The occurrence and bioactivity of polyphenols in Tunisian olive products and by-products: A review. Journal of Food Science, 77(4), R83–R92. https://doi.org/10.1111/j.1750-3841.2011.02599.xCrossRefPubMed

13.

de Bock, M., Derraik, J. G., Brennan, C. M., Biggs, J. B., Morgan, P. E., Hodgkinson, S. C., Hofman, P. L., & Cutfield, W. S. (2013). Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PloS One, 8(3), e57622. https://doi.org/10.1371/journal.pone.0057622CrossRefPubMedPubMedCentral

14.

Burja, B., Kuret, T., Janko, T., Topalović, D., Živković, L., Mrak-Poljšak, K., Spremo-Potparević, B., Žigon, P., Distler, O., Čučnik, S., Sodin-Semrl, S., Lakota, K., & Frank-Bertoncelj, M. (2019). Olive leaf extract attenuates inflammatory activation and dna damage in human arterial endothelial cells. Front Cardiovasc Med., 16(6), 56. https://doi.org/10.3389/fcvm.2019.00056.PMID:31157238;PMCID:PMC6531989CrossRef

15.

Gürbüz, M., & Öğüt, S. (2020). Antidiabetic effect of olive leaf extract on streptozotocin-induced diabetes mellitus in experimental animals. Nutricion Hosp, 37(5), 1012–1021. https://doi.org/10.20960/nh.03051CrossRef

16.

Ismail, M. A., Norhayati, M. N., & Mohamad, N. (2021). Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: A systematic review and meta-analysis. PeerJ, 9, e11173. https://doi.org/10.7717/peerj.11173CrossRefPubMedPubMedCentral

17.

Gonzalez-Ortega, R., Di Mattia, C. D., Pittia, P., & Natasa, P. U. (2023). Effect of heat treatment on phenolic composition and radical scavenging activity of olive leaf extract at different pH conditions: A spectroscopic and kinetic study. Journal of the Science of Food and Agriculture, 103(4), 2047–2056. https://doi.org/10.1002/jsfa.12371CrossRefPubMed

18.

Boss, A., Bishop, K. S., Marlow, G., Barnett, M. P., & Ferguson, L. R. (2016). Evidence to support the anti-cancer effect of olive leaf extract and future directions. Nutrients, 8(8), 513. https://doi.org/10.3390/nu8080513CrossRefPubMedPubMedCentral

19.

Albasher, G. (2018). Anti-fibrogenic and hepatoprotective potential of the ethanolic olive extract on cadmium-induced toxicity in rats. Life Sciences. https://doi.org/10.7537/marslsj150718.01CrossRef

20.

Ben Attia, T., Ben Ali, R., Nahdi, A., Galai, S., Ghali, R., Rammeh, S., Véronique Elmay, M., Mhamdi, A., & Olea, E. L. (2023). Leaf extract mitigates oxidative and histological damage in rat heart tissue exposed to combined noise and toluene: an experimental study. Saudi Pharmaceutical Journal. https://doi.org/10.1016/j.jsps.2023.06.016CrossRefPubMedPubMedCentral

21.

Szczuko, M., Kozioł, I., Kotlęga, D., Brodowski, J., & Drozd, A. (2021). The role of thromboxane in the course and treatment of ischemic stroke: review. International Journal of Molecular Sciences, 22(21), 11644. https://doi.org/10.3390/ijms222111644CrossRefPubMedPubMedCentral

22.

Warner, T. D., Nylander, S., & Whatling, C. (2011). Anti-platelet therapy: Cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy. British Journal of Clinical Pharmacology, 72(4), 619–633. https://doi.org/10.1111/j.1365-2125.2011.03943.xCrossRefPubMedPubMedCentral

23.

Patrono, C. (2016). Cardiovascular effects of cyclooxygenase-2 inhibitors: A mechanistic and clinical perspective. British Journal of Clinical Pharmacology, 82(4), 957–964. https://doi.org/10.1111/bcp.13048CrossRefPubMedPubMedCentral

24.

Zamora, R., Vodovotz, Y., & Billiar, T. R. (2000). Inducible nitric oxide synthase and inflammatory diseases. Molecular Medicine (Cambridge, Mass.)., 6(5), 347–373.PubMedPubMedCentral

25.

Lubos, E., Handy, D. E., & Loscalzo, J. (2008). Role of oxidative stress and nitric oxide in atherothrombosis. Frontiers in Bioscie nce: A Journal and Virtual Library, 13, 5323–5344. https://doi.org/10.2741/3084CrossRef

26.

Mudau, M., Genis, A., Lochner, A., & Strijdom, H. (2012). Endothelial dysfunction: The early predictor of atherosclerosis. Cardiovascular Journal of Africa, 23(4), 222–231. https://doi.org/10.5830/CVJA-2011-068.PMID:22614668;PMCID:PMC3721957CrossRefPubMedPubMedCentral

27.

Chen, Q. M., & Maltagliati, A. J. (2018). Nrf2 at the heart of oxidative stress and cardiac protection. Physiological Genomics, 50(2), 77–97. https://doi.org/10.1152/physiolgenomics.00041.2017CrossRefPubMed

28.

Carlstrom, M., & Montenegro, M. F. (2019). Therapeutic value of stimulating the nitrate-nitrite-nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease. Journal of Internal Medicine, 285(1), 2–18. https://doi.org/10.1111/joim.12818CrossRefPubMed

29.

Senoner, T., & Dichtl, W. (2019). Oxidative stress in cardiovascular diseases: Still a therapeutic target. Nutrients, 11(9), 2090. https://doi.org/10.3390/nu11092090CrossRefPubMedPubMedCentral

30.

Sidhu, R. S., Lee, J. Y., Yuan, C., & Smith, W. L. (2010). Comparison of cyclooxygenase-1 crystal structures: Cross-talk between monomers comprising cyclooxygenase-1 homodimers. Biochemistry, 49(33), 7069–7079. https://doi.org/10.1021/bi1003298CrossRefPubMed

31.

Grädler, U., Fuchss, T., Ulrich, W. R., Boer, R., Strub, A., Hesslinger, C., Anézo, C., Diederichs, K., & Zaliani, A. (2011). Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights. Bioorganic & Medicinal Chemistry Letters, 21(14), 4228–4232. https://doi.org/10.1016/j.bmcl.2011.05.073CrossRef

32.

Hinners, R. G., Burkart, J. K., & Punte, C. L. (1968). Animal inhalation exposure chambers. Archives of Environmental Health: An International Journal, 16(2), 194–206. https://doi.org/10.1080/00039896.1968.10665043CrossRef

33.

Gannouni, N., Mhamdi, A., Tebourbi, O., El May, M., Sakly, M., & Rhouma, K. B. (2013). Qualitative and quantitative assessment of noise at moderate intensities on the extra-auditory system in adult rats. Noise & Health, 15(67), 406–411. https://doi.org/10.4103/1463-1741.121236CrossRef

34.

Bahri, S., Abdennabi, R., Nahdi, A., Ali, R., Mlika, M., Jameleddine S. Effect of Tunisian Olive Leaf Extract on oxidative stress and lung fibrosis in rats. European Respiratory Journal (2020). .56: 3382; congress-2020.3382. https://erj.ersjournals.com/content/56/suppl_64/3382.

35.

Buege, J. A., and Aust, S. D., 1978. [30] Microsomal lipid peroxidation. Biomembranes - Part C: Biological Oxidations, 302–310.

36.

Aebi, H. (1984). Catalase in vitro. Oxygen Radicals in Biological Systems, 105, 121–126.CrossRef

37.

Beyer, W. F., Jr., & Fridovich, I. (1987). Assaying for superoxide dismutase activity: Some large consequences of minor changes in conditions. Analytical Biochemistry, 161(2), 559–566. https://doi.org/10.1016/0003-2697(87)90489-1CrossRefPubMed

38.

García, N., Zazueta, C., & Aguilera-Aguirre, L. (2017). Oxidative stress and inflammation in cardiovascular disease. Oxidative Medicine and Cellular Longevity, 2017, 5853238. https://doi.org/10.1155/2017/5853238CrossRefPubMedPubMedCentral

39.

Pignatelli, P., Menichelli, D., Pastori, D., & Violi, F. (2018). Oxidative stress and cardiovascular disease: New insights. Kardiologia polska, 76(4), 713–722. https://doi.org/10.5603/KP.a2018.0071CrossRefPubMed

40.

Steven, S., Frenis, K., Oelze, M., Kalinovic, S., Kuntic, M., Bayo Jimenez, M. T., Vujacic-Mirski, K., Helmstädter, J., Kröller-Schön, S., Münzel, T., & Daiber, A. (2019). Vascular inflammation and oxidative stress: Major triggers for cardiovascular disease. Oxidative Medicine and Cellular Longevity, 2019, 7092151. https://doi.org/10.1155/2019/7092151CrossRefPubMedPubMedCentral

41.

Charakida, M., & Deanfield, J. E. (2013). Nighttime aircraft noise exposure: Flying towards arterial disease. European Heart Journal, 34(45), 3472–3474. https://doi.org/10.1093/eurheartj/eht339CrossRefPubMed

42.

Münzel, T., Daiber, A., Steven, S., Tran, L. P., Ullmann, E., Kossmann, S., Schmidt, F. P., Oelze, M., Xia, N., Li, H., Pinto, A., Wild, P., Pies, K., Schmidt, E. R., Rapp, S., & Kröller-Schön, S. (2017). Effects of noise on vascular function, oxidative stress, and inflammation: Mechanistic insight from studies in mice. European Heart Journal, 38(37), 2838–2849. https://doi.org/10.1093/eurheartj/ehx081CrossRefPubMedPubMedCentral

43.

Murata, M., Tsujikawa, M., & Kawanishi, S. (1999). Oxidative DNA damage by minor metabolites of toluene may lead to carcinogenesis and reproductive dysfunction. Biochemical and Biophysical Research Communications, 261(2), 478–483. https://doi.org/10.1006/bbrc.1999.1041CrossRefPubMed

44.

Mattia, C. J., Ali, S. F., & Bondy, S. C. (1993). Toluene-induced oxidative stress in several brain regions and other organs. Molecular and Chemical Neuropathology, 18(3), 313–328. https://doi.org/10.1007/BF03160122CrossRefPubMed

45.

Martínez-Alfaro, M., Cárabez-Trejo, A., Gallegos-Corona, M. A., Pedraza-Aboytes, G., Hernández-Chan, N. G., & Leo-Amador, G. E. (2010). Thinner inhalation effects on oxidative stress and DNA repair in a rat model of abuse. Journal of Applied Toxicology : JAT, 30(3), 226–232. https://doi.org/10.1002/jat.1488CrossRefPubMed

46.

Baydas, G., Ozveren, F., Tuzcu, M., & Yasar, A. (2005). Effects of thinner exposure on the expression pattern of neural cell adhesion molecules, level of lipid peroxidation in the brain, and cognitive function in rats. European Journal of Pharmacology, 512(2–3), 181–187. https://doi.org/10.1016/j.ejphar.2005.02.038CrossRefPubMed

47.

Halifeoglu, I., Canatan, H., Ustundag, B., Ilhan, N., & Inanc, F. (2000). Effect of thinner inhalation on lipid peroxidation and some antioxidant enzymes of people working with paint thinner. Cell Biochemistry and Function, 18(4), 263–267. https://doi.org/10.1002/1099-0844(200012)18:4%3c263::AID-CBF882%3e3.0.CO;2-1CrossRefPubMed

48.

Tokunaga, I., Gotohda, T., Ishigami, A., Kitamura, O., & Kubo, S. (2003). Toluene inhalation induced 8-hydroxy-2’-deoxyguanosine formation as the peroxidative degeneration in rat organs. Legal Medicine (Tokyo, Japan), 5(1), 34–41. https://doi.org/10.1016/s1344-6223(03)00004-xCrossRefPubMed

49.

Montes, S., Yee-Rios, Y., & Páez-Martínez, N. (2019). Environmental enrichment restores oxidative balance in animals chronically exposed to toluene: Comparison with melatonin. Brain Research Bulletin, 144, 58–67. https://doi.org/10.1016/j.brainresbull.2018.11.007CrossRefPubMed

50.

Kruk, I., Aboul-Enein, H. Y., Michalska, T., Lichszteld, K., & Kładna, A. (2005). Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein. Luminescence, 20(2), 81–9. https://doi.org/10.1002/bio.808CrossRefPubMed

51.

Geyikoglu, F., Emir, M., Colak, S., Koc, K., Turkez, H., Bakir, M., Hosseinigouzdagani, M., Cerig, S., Keles, O. N., & Ozek, N. S. (2017). Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury. J Food Drug Anal, 25(2), 447–459. https://doi.org/10.1016/j.jfda.2016.07.002CrossRefPubMed

52.

Elmaksoud, H. A. A., Motawea, M. H., Desoky, A. A., Elharrif, M. G., & Ibrahimi, A. (2021). Hydroxytyrosol alleviate intestinal inflammation, oxidative stress, and apoptosis resulted in ulcerative colitis. Biomedicine & Pharmacotherapy = Biomedicine & Pharmacotherapy, 142, 112073. https://doi.org/10.1016/j.biopha.2021.112073CrossRef

53.

Asghari, A. A., Mahmoudabady, M., Shabab, S., & Niazmand, S. (2022). Anti-inflammatory, anti-oxidant and anti-apoptotic effects of olive leaf extract in cardiac tissue of diabetic rats. The Journal of Pharmacy and Pharmacology, 74(7), 961–972. https://doi.org/10.1093/jpp/rgac019CrossRefPubMed

54.

Kurutas, E. B. (2016). The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state. Nutrition Journal, 15(1), 71. https://doi.org/10.1186/s12937-016-0186-5CrossRefPubMedPubMedCentral

55.

Karković Marković, A., Torić, J., Barbarić, M., & Jakobušić Brala, C. (2019). Hydroxytyrosol, tyrosol and derivatives and their potential effects on human health. Molecules (Basel, Switzerland), 24(10), 2001.CrossRefPubMed

56.

Dekdouk, N., Malafronte, N., Russo, D., Faraone, I., De Tommasi, N., Ameddah, S., Severino, L., & Milella, L. (2015). Phenolic Compounds from Olea europaea L. Possess Antioxidant Activity and Inhibit Carbohydrate Metabolizing Enzymes In Vitro. Evidence-Based Complementary and Alternative Medicine: eCAM. https://doi.org/10.1155/2015/684925CrossRefPubMed

57.

Abreu-Naranjo, R., Paredes-Moreta, J. G., Granda-Albuja, G., Iturralde, G., González-Paramás, A. M., & Alvarez-Suarez, J. M. (2020). Bioactive compounds, phenolic profile, antioxidant capacity and effectiveness against lipid peroxidation of cell membranes of Mauritia flexuosa L. fruit extracts from three biomes in the ecuadorian amazon. Heliyon. https://doi.org/10.1016/j.heliyon.2020.e05211CrossRefPubMedPubMedCentral

58.

Amin, M. N., Siddiqui, S. A., Ibrahim, M., Hakim, M. L., Ahammed, M. S., Kabir, A., & Sultana, F. (2020). Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer. SAGE Open Medicine, 8, 2050312120965752. https://doi.org/10.1177/2050312120965752CrossRefPubMedPubMedCentral

59.

Rurik, J. G., Aghajanian, H., & Epstein, J. A. (2021). Immune cells and immunotherapy for cardiac injury and repair. Circulation Research, 128(11), 1766–1779. https://doi.org/10.1161/CIRCRESAHA.121.318005CrossRefPubMedPubMedCentral

60.

Mallat, Z., & Binder, C. J. (2022). The why and how of adaptive immune responses in ischemic cardiovascular disease. Nature Cardiovascular Research, 1, 431–444. https://doi.org/10.1038/s44161-022-00049-1CrossRefPubMedPubMedCentral

61.

Berköz, M., Kahraman, T., Shamsulddin, Z. N., & Krośniak, M. (2021). Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain. Journal of Basic and Clinical Physiology and Pharmacology, 34(2), 187–196. https://doi.org/10.1515/jbcpp-2021-0054CrossRefPubMed

62.

Toukh, M., Gordon, S. P., & Othman, M. (2014). Construction noise induces hypercoagulability and elevated plasma corticosteroids in rats. Clinical and Applied Thrombosis/Hemostasis: Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 20(7), 710–715. https://doi.org/10.1177/1076029613483168CrossRefPubMed

63.

Haft, J. I., & Fani, K. (1973). Stress and the induction of intravascular platelet aggregation in the heart. Circulation, 48(1), 164–169. https://doi.org/10.1161/01.cir.48.1.164CrossRefPubMed

64.

de Roos, B., Zhang, X., Rodriguez Gutierrez, G., Wood, S., Rucklidge, G. J., Reid, M. D., Duncan, G. J., Cantlay, L. L., Duthie, G. G., & O’Kennedy, N. (2011). Anti-platelet effects of olive oil extract: In vitro functional and proteomic studies. European Journal of Nutrition, 50(7), 553–562. https://doi.org/10.1007/s00394-010-0162-3CrossRefPubMed

65.

Rubio-Senent, F., de Roos, B., Duthie, G., Fernández-Bolaños, J., & Rodríguez-Gutiérrez, G. (2015). Inhibitory and synergistic effects of natural olive phenols on human platelet aggregation and lipid peroxidation of microsomes from vitamin E-deficient rats. European Journal of Nutrition, 54(8), 1287–1295. https://doi.org/10.1007/s00394-014-0807-8CrossRefPubMed

66.

Sabahi A, Moradi I. The Effects of Noise Exposure on Rat’s Hematologic Parameters and Red Cell Indices. IJMS. 2002;27(2) [Google Scholar]

67.

Mohammadi, S., Labbafinejad, Y., & Attarchi, M. (2010). Combined effects of ototoxic solvents and noise on hearing in automobile plant workers in Iran. Arhiv za Higijenu Rada i Toksikologiju, 61(3), 267–274. https://doi.org/10.2478/10004-1254-61-2010-2013CrossRefPubMed

Title: Simultaneous Exposure to Noise and Toluene Induces Oxidative and Inflammatory Damage in the Heart of Wistar Rats: Therapeutic Potential of Olea europaea L. Leaf Extract
Authors: Takoua Ben Attia
Afef Nahdi
Mabrouk Horchani
Ridha Ben Ali
Hichem Ben Jannet
Said Galai
Michèle Véronique Elmay
Abada Mhamdi
Publication date: 09-05-2024
Publisher: Springer US
Published in: Cardiovascular Toxicology
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-024-09867-0

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Simultaneous Exposure to Noise and Toluene Induces Oxidative and Inflammatory Damage in the Heart of Wistar Rats: Therapeutic Potential of Olea europaea L. Leaf Extract

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page