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01-11-2013 | Interventional

Simultaneous dual-isotope SPECT/CT with ^99mTc- and ¹¹¹In-labelled albumin microspheres in treatment planning for SIRT

Authors: Moritz Palmowski, Andreas Goedicke, Andreas Vogg, Götz Christ, Georg Mühlenbruch, Hans J. Kaiser, Rolf W. Günther, Christiane K. Kuhl, Felix M. Mottaghy, Florian F. Behrendt

Published in: European Radiology | Issue 11/2013

Abstract

Objectives

To investigate simultaneous dual-isotope SPECT/CT with two differently radioisotope-labelled albumin-microsphere fractions for treatment planning of hepatic radioembolisation.

Methods

In addition to ^99mTechnetium-labelled albumin microspheres (commercially available), we performed labelling with ¹¹¹Indium. Binding stability of ¹¹¹Indium-labelled microspheres was tested in vitro and in vivo in mice. Simultaneous dual-isotope SPECT/CT imaging was validated in an anthropomorphic torso phantom; subsequently, dual-isotope SPECT/CT was performed under in-vivo conditions in pigs (n = 3) that underwent transarterial injection of ^99mTechnetium- and ¹¹¹Indium-labelled microspheres in the liver (right and left hepatic artery, respectively), in both kidneys and in the gluteal musculature. In total, n = 18 transarterial injections were performed.

Results

In-vitro testing and in-vivo studies in mice documented high binding stability for both ^99mTechnetium-labelled and ¹¹¹Indium-labelled microsphere fractions. In phantom studies, simultaneous dual-isotope SPECT/CT enabled reliable separation of both isotopes. In pigs, the identified deposition of both isotopes could be accurately matched with intended injection targets (100 %, 18/18 intended injection sites). Furthermore, an incidental deposition of ^99mTechnetium-labelled microspheres in the stomach could be correlated to the test injection into a right hepatic artery.

Conclusion

Simultaneous dual-isotope SPECT/CT after transarterial injection with ^99mTechnetium- and ¹¹¹Indium-labelled microspheres is feasible. Thus, it may offer additional, valuable information compared to single ^99mTechnetium-labelled albumin examinations.

Key Points

• Simultaneous dual-isotope SPECT/CT with ¹¹¹ In- and ^99m Tc-labelled albumin microspheres is feasible.

• Differentiation of two microsphere fractions after transarterial injection is possible.

• The origin of an extra-hepatic microsphere deposition can be correlated to the corresponding artery.

• This technique could reduce the setup time for selective internal radiation treatment.

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Title: Simultaneous dual-isotope SPECT/CT with 99mTc- and 111In-labelled albumin microspheres in treatment planning for SIRT
Authors: Moritz Palmowski
Andreas Goedicke
Andreas Vogg
Götz Christ
Georg Mühlenbruch
Hans J. Kaiser
Rolf W. Günther
Christiane K. Kuhl
Felix M. Mottaghy
Florian F. Behrendt
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 11/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-013-2916-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Simultaneous dual-isotope SPECT/CT with ^99mTc- and ¹¹¹In-labelled albumin microspheres in treatment planning for SIRT

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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