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01-12-2019 | Silicone | Original Research Article

Multifocal electroretinogram in eyes with intravitreal silicone oil and changes following silicone oil removal

Authors: Devesh Kumawat, Pranita Sahay, Karthikeyan Mahalingam, S. J. Vikas, Sagnik Sen, Mousumi Banerjee, Pradeep Venkatesh

Published in: Documenta Ophthalmologica | Issue 3/2019

Abstract

Purpose

To determine the effect of intravitreal silicone oil (SO) on multifocal electroretinogram (mfERG) and the changes in mfERG following SO removal.

Methods

Twelve eyes of 12 patients with SO in vitreous cavity with corrected distance visual acuity (CDVA) > 20/200 were prospectively enrolled as cases over a period from July 2016 to June 2018. The fellow normal eyes served as control. The eyes were evaluated with P1 and N1 wave amplitude and implicit time on mfERG at baseline, 1 and 4 weeks after SO removal.

Results

The mean age was 44.9 ± 18.9 (range 18–74) years. The indication for SO injection was retinal detachment (n = 9, three macula-on eyes, six macula-off eyes) and endophthalmitis (n = 3). The median (range) LogMAR CDVA at baseline was 0.54 (0.18–0.78) in cases and did not change post-SO removal (p = 0.29). There was a significant decrease in average P1 and N1 wave amplitude (p = 0.0001 and 0.0001, respectively) and delay in average P1 and N1 wave implicit time (p = 0.0002 and 0.021, respectively) in cases as compared to controls. The macular status and duration of SO tamponade did not have a significant correlation with mfERG parameters. There was a significant increase in average P1 and N1 wave amplitude (p = 0.009 and 0.003, respectively) at 1 week following SO removal but no change in average P1 and N1 wave implicit time (p = 0.41 and 0.37, respectively).

Conclusion

mfERG may be reliably performed for the assessment of macular function in SO-filled eyes. Intravitreal SO exerts an insulating effect on the density of the electric potentials.

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Title: Multifocal electroretinogram in eyes with intravitreal silicone oil and changes following silicone oil removal
Authors: Devesh Kumawat
Pranita Sahay
Karthikeyan Mahalingam
S. J. Vikas
Sagnik Sen
Mousumi Banerjee
Pradeep Venkatesh
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keywords: Silicone
Retinal Detachment
Vitrectomy
Published in: Documenta Ophthalmologica / Issue 3/2019
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-019-09710-w

At a glance: The STEP trials

Springer Medicine

Multifocal electroretinogram in eyes with intravitreal silicone oil and changes following silicone oil removal

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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