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Published in: Current Hypertension Reports 3/2014

01-03-2014 | Therapeutic Trials (B Pitt, Section Editor)

Should Patients with Obesity and Hypertension be Treated Differently from Those Who Are Not Obese?

Authors: Michael J. Bloch, Anthony J. Viera

Published in: Current Hypertension Reports | Issue 3/2014

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Abstract

Obesity and hypertension frequently coexist. Measuring blood pressure (BP) accurately in obese patients is challenging and may require strategies that are less accurate, such as forearm cuffing or use of wrist cuffs. Pathophysiologic mechanisms of hypertension may differ between obese and non-obese individuals, which may result in differing effects of common BP-lowering medications. However, to date, there is insufficient trial data to recommend a different approach to medication selection based on body mass index. Additionally, the goal BP is generally not different between obese and non-obese patients. Weight loss should be emphasized for obese patients with hypertension, and interventions in addition to diet and exercise may include weight loss medications and bariatric surgery. Recognition and treatment of obstructive sleep apnea is also important.
Literature
2.
go back to reference Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity among adults: United States, 2011-2012. NCHS Data Brief. 2013;131:1–8.PubMed Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity among adults: United States, 2011-2012. NCHS Data Brief. 2013;131:1–8.PubMed
3.
go back to reference Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309:71–82.PubMedCrossRef Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309:71–82.PubMedCrossRef
4.
go back to reference Quesenberry Jr CP, Caan B, Jacobson A. Obesity, health services use, and health care costs among members of a health maintenance organization. Arch Intern Med. 1998;158:466–72.PubMedCrossRef Quesenberry Jr CP, Caan B, Jacobson A. Obesity, health services use, and health care costs among members of a health maintenance organization. Arch Intern Med. 1998;158:466–72.PubMedCrossRef
5.
go back to reference Thompson D, Brown JB, Nichols GA, Elmer PJ, Oster G. Body mass index and future healthcare costs: a retrospective cohort study. Obes Res. 2001;9:210–8.PubMedCrossRef Thompson D, Brown JB, Nichols GA, Elmer PJ, Oster G. Body mass index and future healthcare costs: a retrospective cohort study. Obes Res. 2001;9:210–8.PubMedCrossRef
6.
go back to reference Finkelstein EA, Fiebelkorn IC, Wang G. National medical spending attributable to overweight and obesity: how much, and who's paying? Health Aff (Millwood). 2003 Jan-Jun;Suppl Web Exclusives:W3–219–26. Finkelstein EA, Fiebelkorn IC, Wang G. National medical spending attributable to overweight and obesity: how much, and who's paying? Health Aff (Millwood). 2003 Jan-Jun;Suppl Web Exclusives:W3–219–26.
7.
go back to reference Landsberg L, Aronne LJ, Beilin L, Burke V, Igel LI, Lloyd-Jones D, et al. Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment. A position paper of The Obesity Society and the American Society of Hypertension. J Clin Hypertens (Greenwich). 2013;15:14–33. Reviews the pathophysiology of obesity-related hypertension and provides recommendations for management, including medical treatments for obesity.CrossRef Landsberg L, Aronne LJ, Beilin L, Burke V, Igel LI, Lloyd-Jones D, et al. Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment. A position paper of The Obesity Society and the American Society of Hypertension. J Clin Hypertens (Greenwich). 2013;15:14–33. Reviews the pathophysiology of obesity-related hypertension and provides recommendations for management, including medical treatments for obesity.CrossRef
8.
go back to reference Kotchen TA. Obesity-related hypertension: epidemiology, pathophysiology, and clinical management. Am J Hypertens. 2010;23(11):1170–8.PubMedCrossRef Kotchen TA. Obesity-related hypertension: epidemiology, pathophysiology, and clinical management. Am J Hypertens. 2010;23(11):1170–8.PubMedCrossRef
9.
go back to reference Doll S, Paccaud F, Bovet P, Burnier M, Wietlisbach V. Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries. Int J Obes Relat Metab Disord. 2002;26(1):48–57.PubMedCrossRef Doll S, Paccaud F, Bovet P, Burnier M, Wietlisbach V. Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries. Int J Obes Relat Metab Disord. 2002;26(1):48–57.PubMedCrossRef
10.
go back to reference Graves JW, Bailey KR, Sheps SG. The changing distribution of arm circumferences in NHANES III and NHANES 2000 and its impact on the utility of the 'standard adult' blood pressure cuff. Blood Press Monit. 2003;8(6):223–7.PubMedCrossRef Graves JW, Bailey KR, Sheps SG. The changing distribution of arm circumferences in NHANES III and NHANES 2000 and its impact on the utility of the 'standard adult' blood pressure cuff. Blood Press Monit. 2003;8(6):223–7.PubMedCrossRef
11.
go back to reference Ostchega Y, Huges JP, Zhang G, et al. Mean mid-arm circumference and blood pressure cuff sizes for US adults: National Health and Nutrition Examination Survey, 1999-2010. Blood Press Monit. 2013;18(3):138–43. This report from the NHANES observational study suggests that 42.9% of men and 25.3% of women require a large cuff for accurate BP measurement. PubMedCrossRef Ostchega Y, Huges JP, Zhang G, et al. Mean mid-arm circumference and blood pressure cuff sizes for US adults: National Health and Nutrition Examination Survey, 1999-2010. Blood Press Monit. 2013;18(3):138–43. This report from the NHANES observational study suggests that 42.9% of men and 25.3% of women require a large cuff for accurate BP measurement. PubMedCrossRef
12.
go back to reference Pickering TG, Hall JE, Appel LJ, et al. Recommendations for blood pressure measurement in humans and experimental animals: Part 1: Blood Pressure Measurement in Humans: A Statement for Professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension. 2005;45:142–61.PubMedCrossRef Pickering TG, Hall JE, Appel LJ, et al. Recommendations for blood pressure measurement in humans and experimental animals: Part 1: Blood Pressure Measurement in Humans: A Statement for Professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension. 2005;45:142–61.PubMedCrossRef
13.
go back to reference Palatini P, Parati G. Blood pressure measurement in very obese patients: A challenging problem. J Hypertens. 2011;29:425–9. This seminal article remains the most comprehensive summary of recommendations for BP measurement. Office, home, and ambulatory BP measurement are all covered, with emphasis on practical recommendations. PubMedCrossRef Palatini P, Parati G. Blood pressure measurement in very obese patients: A challenging problem. J Hypertens. 2011;29:425–9. This seminal article remains the most comprehensive summary of recommendations for BP measurement. Office, home, and ambulatory BP measurement are all covered, with emphasis on practical recommendations. PubMedCrossRef
14.
go back to reference Bonso E, Saladini F, Zanier A, et al. Accuracy of a single rigid conical cuff with standard size bladder coupled to an automated oscillometric device over a wide range of arm circumferences. Hypertens Res. 2010;33:1186–91.PubMedCrossRef Bonso E, Saladini F, Zanier A, et al. Accuracy of a single rigid conical cuff with standard size bladder coupled to an automated oscillometric device over a wide range of arm circumferences. Hypertens Res. 2010;33:1186–91.PubMedCrossRef
15.
go back to reference Mourad JJ, Lopez-Sublet M, Aoun-Bahous S, et al. Impact of miscuffing during home blood pressure measurement on the prevalence of masked hypertension. Am J Hypertens. 2013;26(10):1205–9.PubMedCrossRef Mourad JJ, Lopez-Sublet M, Aoun-Bahous S, et al. Impact of miscuffing during home blood pressure measurement on the prevalence of masked hypertension. Am J Hypertens. 2013;26(10):1205–9.PubMedCrossRef
16.
go back to reference Maxwell GF, Prujit JF, Amtzenius AC. Comparison of conical cuff and the standard rectangular cuffs. Int J Epidemiol. 1985;14:468–72.PubMedCrossRef Maxwell GF, Prujit JF, Amtzenius AC. Comparison of conical cuff and the standard rectangular cuffs. Int J Epidemiol. 1985;14:468–72.PubMedCrossRef
17.
go back to reference Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72.PubMedCrossRef Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72.PubMedCrossRef
18.
go back to reference Krause T, Lovibond K, Caulfield M, McCormack T, Williams B, Guideline Development Group. Management of hypertension: summary of NICE guidance. BMJ. 2011;25:343. Krause T, Lovibond K, Caulfield M, McCormack T, Williams B, Guideline Development Group. Management of hypertension: summary of NICE guidance. BMJ. 2011;25:343.
19.
go back to reference Mancia G, Fagard R, Narkiewicz K, Redán J, Zanchetti A, Böhm M, et al. Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2013;31(10):1925–38. This article is one of the more recent guidelines for hypertension management. CrossRef Mancia G, Fagard R, Narkiewicz K, Redán J, Zanchetti A, Böhm M, et al. Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2013;31(10):1925–38. This article is one of the more recent guidelines for hypertension management. CrossRef
20.
go back to reference Flack JM, Sica DA, Bakris G, Brown AL, Ferdinand KC, Grimm Jr RH, et al. Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement. Hypertension. 2010;56(5):780–800.PubMedCrossRef Flack JM, Sica DA, Bakris G, Brown AL, Ferdinand KC, Grimm Jr RH, et al. Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement. Hypertension. 2010;56(5):780–800.PubMedCrossRef
21.
go back to reference James PA, Oparil S, Carter BL, et al. Evidence Based Guidelines for the Management of High Blood Pressure in Adults: Report from the panel members appointed to the eighth joint national committee (JNC8). JAMA. 2013. doi:10.1001/jama.2013.284427. James PA, Oparil S, Carter BL, et al. Evidence Based Guidelines for the Management of High Blood Pressure in Adults: Report from the panel members appointed to the eighth joint national committee (JNC8). JAMA. 2013. doi:10.​1001/​jama.​2013.​284427.
22.
go back to reference Wilson PW, D’Agostino RB, Sullivan L, et al. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 2002;162:1867–72.PubMedCrossRef Wilson PW, D’Agostino RB, Sullivan L, et al. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 2002;162:1867–72.PubMedCrossRef
23.
go back to reference Uretsky S, Messerli FH, Bangalore S, et al. Obesity paradox in patients with hypertension and coronary artery disease. Am J Med. 2007;120:863–70.PubMedCrossRef Uretsky S, Messerli FH, Bangalore S, et al. Obesity paradox in patients with hypertension and coronary artery disease. Am J Med. 2007;120:863–70.PubMedCrossRef
24.
go back to reference Wassertheil-Smoller S, Fann C, Allman RM, et al. Relation of low body mass to death and stroke in systolic hypertension in the elderly program. Arch Intern Med. 2000;160:494–500.PubMedCrossRef Wassertheil-Smoller S, Fann C, Allman RM, et al. Relation of low body mass to death and stroke in systolic hypertension in the elderly program. Arch Intern Med. 2000;160:494–500.PubMedCrossRef
25.
go back to reference Weber MA, Jamerson K, Bakris G, et al. Effects of body size and hypertension treatment on cardiovascular event rates: subanalysis of the ACCOMPLISH randomized controlled trial. Lancet. 2013. This pre-specified analysis of the results of the ACCOMPLISH study suggests that the combination of an ACE inhibitor + a calcium channel blocker offers equal reduction in CV events in lean and obese patients, but that the combination of an ACE inhibitor + diuretic offers better reduction of CV events in overweight as opposed to lean individuals. Weber MA, Jamerson K, Bakris G, et al. Effects of body size and hypertension treatment on cardiovascular event rates: subanalysis of the ACCOMPLISH randomized controlled trial. Lancet. 2013. This pre-specified analysis of the results of the ACCOMPLISH study suggests that the combination of an ACE inhibitor + a calcium channel blocker offers equal reduction in CV events in lean and obese patients, but that the combination of an ACE inhibitor + diuretic offers better reduction of CV events in overweight as opposed to lean individuals.
26.
go back to reference Jamerson K, Weber MA, Bakris G, et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high risk patients. N Eng J Med. 2008;359:2417–28.CrossRef Jamerson K, Weber MA, Bakris G, et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high risk patients. N Eng J Med. 2008;359:2417–28.CrossRef
27.
go back to reference Goodfriend TL, Calhoun DA. Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. Hypertension. 2004;43(3):518–24.PubMedCrossRef Goodfriend TL, Calhoun DA. Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. Hypertension. 2004;43(3):518–24.PubMedCrossRef
29.
go back to reference de Souza F, Muxfeldt E, Fiszman R, Salles G. Efficacy of spironolactone therapy in patients with true resistant hypertension. Hypertens. 2010;55:147–52.CrossRef de Souza F, Muxfeldt E, Fiszman R, Salles G. Efficacy of spironolactone therapy in patients with true resistant hypertension. Hypertens. 2010;55:147–52.CrossRef
30.
go back to reference Chapman N, Dobson J, Wilson S, et al. Effect of spironolactone on blood pressure in subjects with resistant hypertension. Hypertens. 2007;49:839–45.CrossRef Chapman N, Dobson J, Wilson S, et al. Effect of spironolactone on blood pressure in subjects with resistant hypertension. Hypertens. 2007;49:839–45.CrossRef
31.
go back to reference ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker versus diuretic. JAMA. 2002;288(23):2981–97.CrossRef ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker versus diuretic. JAMA. 2002;288(23):2981–97.CrossRef
32.
go back to reference Vgontzas AN, Tan TL, Bixler EO, Martin LF, Shubert D, Kales A. Sleep apnea and sleep disruption in obese patients. Arch Intern Med. 1994;154:1705–11.PubMedCrossRef Vgontzas AN, Tan TL, Bixler EO, Martin LF, Shubert D, Kales A. Sleep apnea and sleep disruption in obese patients. Arch Intern Med. 1994;154:1705–11.PubMedCrossRef
33.
go back to reference Frey WC, Pilcher J. Obstructive sleep-related breathing disorders in patients evaluated for bariatric surgery. Obes Surg. 2003;13:676–83.PubMedCrossRef Frey WC, Pilcher J. Obstructive sleep-related breathing disorders in patients evaluated for bariatric surgery. Obes Surg. 2003;13:676–83.PubMedCrossRef
34.
go back to reference Logan AG, Perlikowski SM, Mente A, et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens. 2001;19:2271–7.PubMedCrossRef Logan AG, Perlikowski SM, Mente A, et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens. 2001;19:2271–7.PubMedCrossRef
35.
go back to reference Mulgrew AT, Fox N, Ayas NT, Ryan CF. Diagnosis and initial management of obstructive sleep apnea without polysomnography. Ann Intern Med. 2007;146:157–66.PubMedCrossRef Mulgrew AT, Fox N, Ayas NT, Ryan CF. Diagnosis and initial management of obstructive sleep apnea without polysomnography. Ann Intern Med. 2007;146:157–66.PubMedCrossRef
36.
go back to reference Skomro RP, Gjevre J, Reid J, et al. Outcomes of home-based diagnosis and treatment of obstructive sleep apnea. Chest. 2010;138(2):257–63.PubMedCrossRef Skomro RP, Gjevre J, Reid J, et al. Outcomes of home-based diagnosis and treatment of obstructive sleep apnea. Chest. 2010;138(2):257–63.PubMedCrossRef
37.
go back to reference Yalamanchali S, Farajian V, Hamilton C, Pott TR, Samuelson CG, Friedman M. Diagnosis of obstructive sleep apnea by peripheral arterial tonometry: meta-analysis. JAMA Otolaryngol Head Neck Surg. 2013. doi:10.1001/jamaoto.2013.5338.PubMed Yalamanchali S, Farajian V, Hamilton C, Pott TR, Samuelson CG, Friedman M. Diagnosis of obstructive sleep apnea by peripheral arterial tonometry: meta-analysis. JAMA Otolaryngol Head Neck Surg. 2013. doi:10.​1001/​jamaoto.​2013.​5338.PubMed
38.
go back to reference Becker HF, Jerrentrup A, Ploch T, et al. Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation. 2003;107(1):68–73.PubMedCrossRef Becker HF, Jerrentrup A, Ploch T, et al. Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation. 2003;107(1):68–73.PubMedCrossRef
39.
go back to reference Alajmi M, Mulgrew AT, Fox J, et al. Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials. Lung. 2007;185(2):67–72.PubMedCrossRef Alajmi M, Mulgrew AT, Fox J, et al. Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials. Lung. 2007;185(2):67–72.PubMedCrossRef
40.
go back to reference Somers VK, White DP, Ain R, et al. Sleep apnea and cardiovascular disease: An American heart association/American college of cardiology foundation scientific statement from the American heart association council for high blood pressure research professional education committee. J Am Coll Cardiol. 2008;5d2(8):686–717. This scientific statement suggests that the presence of OSA is closely associated with hypertension and other CV disease, but that the effect of CPAP on BP reduction in hypertensive patients with OSA is modest – on the order of about 3 mmHg systolic. CrossRef Somers VK, White DP, Ain R, et al. Sleep apnea and cardiovascular disease: An American heart association/American college of cardiology foundation scientific statement from the American heart association council for high blood pressure research professional education committee. J Am Coll Cardiol. 2008;5d2(8):686–717. This scientific statement suggests that the presence of OSA is closely associated with hypertension and other CV disease, but that the effect of CPAP on BP reduction in hypertensive patients with OSA is modest – on the order of about 3 mmHg systolic. CrossRef
41.
go back to reference Martinez-Garcia MA, Capote F, Campos-Rodriguez F, et al. Effect of CPAP on blood pressure in patient with obstructive sleep apnea and resistant hypertension: The HIPARCO Randomized Clinical Trial. JAMA. 2013;310(22):2407–15.PubMed Martinez-Garcia MA, Capote F, Campos-Rodriguez F, et al. Effect of CPAP on blood pressure in patient with obstructive sleep apnea and resistant hypertension: The HIPARCO Randomized Clinical Trial. JAMA. 2013;310(22):2407–15.PubMed
42.
go back to reference Barbe F, Duran-Cantolla J, Sanchez-de-la-Torre M, et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized trial. JAMA. 2012;307(20):2161–8.PubMedCrossRef Barbe F, Duran-Cantolla J, Sanchez-de-la-Torre M, et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized trial. JAMA. 2012;307(20):2161–8.PubMedCrossRef
43.
go back to reference Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM. Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2003;42:878–84.PubMedCrossRef Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM. Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2003;42:878–84.PubMedCrossRef
44.
go back to reference Bakris G, Calhoun D, Egan B, Hellmann C, Dolker M, Kingma I. Orlistat improves blood pressure control in obese subjects with treated but inadequately controlled hypertension. J Hypertens. 2002;20:2257–67.PubMedCrossRef Bakris G, Calhoun D, Egan B, Hellmann C, Dolker M, Kingma I. Orlistat improves blood pressure control in obese subjects with treated but inadequately controlled hypertension. J Hypertens. 2002;20:2257–67.PubMedCrossRef
45.
go back to reference Siebenhofer A, Jeitler K, Horvath K, Berghold A, Siering U, Semlitsch T. Long-term effects of weight-reducing drugs in hypertensive patients. Cochrane Database Syst Rev. 2013;3:CD007654.PubMed Siebenhofer A, Jeitler K, Horvath K, Berghold A, Siering U, Semlitsch T. Long-term effects of weight-reducing drugs in hypertensive patients. Cochrane Database Syst Rev. 2013;3:CD007654.PubMed
46.
go back to reference Sjöström L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.PubMedCrossRef Sjöström L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.PubMedCrossRef
47.
go back to reference Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–52.PubMedCrossRef Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–52.PubMedCrossRef
48.
go back to reference Ricci C, Gaeta M, Rausa E, Macchitella Y, Bonavina L. Early impact of bariatric surgery on type II diabetes, hypertension, and hyperlipidemia: a systematic review, meta-analysis and meta-regression on 6,587 patients. Obes Surg. 2013. Ricci C, Gaeta M, Rausa E, Macchitella Y, Bonavina L. Early impact of bariatric surgery on type II diabetes, hypertension, and hyperlipidemia: a systematic review, meta-analysis and meta-regression on 6,587 patients. Obes Surg. 2013.
49.
go back to reference Courcoulas AP, Christian NJ, Belle SH, Berk PD, Flum DR, Garcia L, et al. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA. 2013. doi:10.1001/jama.2013.280928. This recently published study highlights the weight loss and metabolic benefits at three years of weight loss achieved through bariatric surgery. Courcoulas AP, Christian NJ, Belle SH, Berk PD, Flum DR, Garcia L, et al. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA. 2013. doi:10.​1001/​jama.​2013.​280928. This recently published study highlights the weight loss and metabolic benefits at three years of weight loss achieved through bariatric surgery.
50.
go back to reference Symplicity HTN-1 Investigators. Catheter-based renal sympathetic denervation for resistant hypertension durability of blood pressure reduction out to 24 months. Hypertension. 2011;57:911–7.CrossRef Symplicity HTN-1 Investigators. Catheter-based renal sympathetic denervation for resistant hypertension durability of blood pressure reduction out to 24 months. Hypertension. 2011;57:911–7.CrossRef
51.
go back to reference Symplicity HTN-2 Investigators. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903–9.CrossRef Symplicity HTN-2 Investigators. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903–9.CrossRef
Metadata
Title
Should Patients with Obesity and Hypertension be Treated Differently from Those Who Are Not Obese?
Authors
Michael J. Bloch
Anthony J. Viera
Publication date
01-03-2014
Publisher
Springer US
Published in
Current Hypertension Reports / Issue 3/2014
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI
https://doi.org/10.1007/s11906-014-0418-z

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