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Open Access 01-12-2014 | Short report

Short communication: timeline of radiation-induced kidney function loss after stereotactic ablative body radiotherapy of renal cell carcinoma as evaluated by serial ^99mTc-DMSA SPECT/CT

Authors: Price Jackson, Farshad Foroudi, Daniel Pham, Michael S Hofman, Nicholas Hardcastle, Jason Callahan, Tomas Kron, Shankar Siva

Published in: Radiation Oncology | Issue 1/2014

Abstract

Background

Stereotactic ablative body radiotherapy (SABR) has been proposed as a definitive treatment for patients with inoperable primary renal cell carcinoma. However, there is little documentation detailing the radiobiological effects of hypofractionated radiation on healthy renal tissue.

Findings

In this study we describe a methodology for assessment of regional change in renal function in response to single fraction SABR of 26 Gy. In a patient with a solitary kidney, detailed follow-up of kidney function post-treatment was determined through 3-dimensional SPECT/CT imaging and ⁵¹Cr-EDTA measurements. Based on measurements of glomerular filtration rate, renal function declined rapidly by 34% at 3 months, plateaued at 43% loss at 12 months, with minimal further decrease to 49% of baseline by 18 months.

Conclusions

The pattern of renal functional change in ^99mTc-DMSA uptake on SPECT/CT imaging correlates with dose delivered. This study demonstrates a dose effect relationship of SABR with loss of kidney function.

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Title: Short communication: timeline of radiation-induced kidney function loss after stereotactic ablative body radiotherapy of renal cell carcinoma as evaluated by serial 99mTc-DMSA SPECT/CT
Authors: Price Jackson
Farshad Foroudi
Daniel Pham
Michael S Hofman
Nicholas Hardcastle
Jason Callahan
Tomas Kron
Shankar Siva
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2014
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/s13014-014-0253-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Short communication: timeline of radiation-induced kidney function loss after stereotactic ablative body radiotherapy of renal cell carcinoma as evaluated by serial ^99mTc-DMSA SPECT/CT

Abstract

Background

Findings

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Findings

Conclusions

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